Association between blood pressure assessd by invasive/noninvasive methods beat by beat and left ventricular diastolic dysfunction

• Project/Area Number: 18K08045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Jichi Medical University
• Principal Investigator: Kabutoya Tomoyuki 自治医科大学, 医学部, 准教授 (00458291)
• Co-Investigator(Kenkyū-buntansha): 渡部 智紀 自治医科大学, 医学部, 講師 (00570269) ; 苅尾 七臣 自治医科大学, 医学部, 教授 (60285773) ; 星出 聡 自治医科大学, 医学部, 教授 (90326851)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 心拍出量 / 高血圧 / 拡張障害

Outline of Final Research Achievements

We developed a wrist device for pulse rate and blood pressure, which is summarized in the papers. The pulse rate variability of a wrist device was found to be useful in diagnosis for atrial fibrillation, and the wrist blood pressure measurement met the criteria for guideline validation. The variation of cardiac output beat to beat was examined mainly in pacemaker settings. Examination of the pacemaker revealed that cardiac output decreased with increasing heart rate, but was offset by cardiac output. The study also showed that the changes in cardiac output differed depending on the patient background of patients with cardiac resynchronization therapy.

Academic Significance and Societal Importance of the Research Achievements

1心拍ごとの心拍変動、血圧変動について、手首型デバイスの実用化につながっている。心拍変動による心房細動の早期発見は、適切な介入により心房細動の抑制につながる。手首型血圧測定は上腕型に比べて簡便で、よりよい家庭血圧管理に役立てられる。1心拍おきの循環動態の変化について、非侵襲的に測定を行えることで心臓ペースメーカー植え込み患者の適切な設定を行うことができ、心不全予防に役立てられる。

Research Products

• [Journal Article] Comparison of heart rate and cardiac output of VVI pacemaker settings in patients with atrial fibrillation with bradycardia. (2023)
  • Author(s): Yokota A, Kabutoya T, Mitama T, Okuyama T, Watanabe H, Kamioka M, Watanabe T, Komori T, Imai Y, Kario K.
  • Journal Title: Journal of Arrhythmia Volume: 39 Issue: 4 Pages: 574-579
  • DOI: 10.1002/joa3.12874
  • Peer Reviewed / Open Access
• [Journal Article] Automatically assessed P-wave predicts cardiac events independently of left atrial enlargement in patients with cardiovascular risks: The Japan Morning Surge-Home Blood Pressure Study (2021)
  • Author(s): Yokota A, Kabutoya T, Hoshide S, Kario K.
  • Journal Title: J Clin Hypertens (Greenwich) . Volume: 23 Pages: 301-308
  • Peer Reviewed
• [Journal Article] Validation of a wrist-type home nocturnal blood pressure monitor in the sitting and supine position according to the ANSI/AAMI/ISO81060-2:2013 guidelines: Omron HEM-9601T. (2020)
  • Author(s): Kuwabara M, Harada K, Hishiki Y, Ohkubo T, Kario K, Imai Y.
  • Journal Title: J Clin Hypertens (Greenwich). Volume: - Issue: 6 Pages: 970-978
  • DOI: 10.1111/jch.13864
  • Peer Reviewed
• [Presentation] CRT植込み患者の左脚ブロックの有無と植込み前後の血行動態および予後 の検討 (2024)
  • Author(s): 三玉唯由季，甲谷友幸，奥山貴文，渡邉裕昭，横田彩子，上岡正志，渡部智紀，小森孝洋，牧元久樹，今井 靖， 苅尾七臣
  • Organizer: 第16回植込みデバイス関連冬季大会
• [Presentation] ACUTE HEMODYNAMIC CHANGE WAS ASSOCIATED WITH LEFT VENTRICULAR REVERSE REMODELING AFTER CARDIAC RESYNCHRONIZATION THERAPY IMPLANTATION (2023)
  • Author(s): Takahiro Komori 、Tomoyuki Kabutoya 、Ayako Yokota 、 Tadayuki Mitama 、Hiroaki Watanabe 、 Masashi Kamioka 、Hisaki Makimoto 、Tomonori Watanabe 、Yasushi Imai 、Kazuomi Kario
  • Organizer: 第69回日本不整脈心電学会学術大会
• [Presentation] ACUTE HEMODYNAMIC CHANGES AND PROGNOSIS OF ISCHEMIC HEART DISEASE AND DILATED CARDIOMYOPATHY IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY IMPLANTATION (2023)
  • Author(s): Tomoyuki Kabutoya 、Takahiro Komori 、Tadayuki Mitama 、 Hiroaki Watanabe 、Ayako Yokota 、 Masashi Kamioka 、Tomonori Watanabe 、Hisaki Makimoto 、Yasushi Imai 、Kazuomi Kario
  • Organizer: 第69回日本不整脈心電学会学術大会
• [Presentation] 心房細動患者のCRTの非侵襲的心拍出量測定で測定した血行動態の改善度は左室 収縮能の改善に寄与する (2023)
  • Author(s): 横田彩子、奥山貴文、渡邉裕昭、上岡正志、渡部智紀、小森孝洋、今井靖、苅尾七臣
  • Organizer: 日本不整脈心電学会第15回植込みデバイス関連冬季大会
• [Presentation] Association Between High-Sensitivity Cardiac Troponin T, Left Atrial Volume, and Atherosclerosis in Patients with Atrial Fibrillation (2022)
  • Author(s): Takafumi Okuyama, Tomoyuki Kabutoya, Hiroaki Watanabe, Ayako Yokota, Masashi Kamioka, Takahiro Komori, Tomonori Watanabe, Yasushi Imai, Kazuomi Kario
  • Organizer: 第68回日本不整脈心電学会学術集会
• [Presentation] Hemodynamic Study of VVI Pacemaker in Atrial Fibrillation Patients (2022)
  • Author(s): Ayako Yokota, Tomoyuki Kabutoya, Takafumi Okuyama Hiroaki Watanabe, Masashi Kamioka, Takahiro Komori Tomonori Watanabe, Yasushi Imai, Kazuomi Kario
  • Organizer: 第68回日本不整脈心電学会学術集会
• [Presentation] 手首型脈波計の心房細動診断能 (2019)
  • Author(s): 甲谷 友幸、今井 靖、渡部 智紀、星出 聡、苅尾 七臣
  • Organizer: 日本高血圧学会第8回臨床高血圧フォーラム