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Fundamental research on direct myocardial reprogramming of the myocardium for biotransformation into infarct lesions.

Research Project

Project/Area Number 18K08047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionKeio University

Principal Investigator

YAMAKAWA Hiroyuki  慶應義塾大学, 医学部(信濃町), 講師 (80465020)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords心筋再生 / 心筋症 / 心筋リプログラミング / 心筋リプロウグラミング / 遺伝子治療 / リプログラミング / 遺伝子編集 / 心筋梗塞 / リプロウグラミング / 直接リプログラミング / 遺伝子導入 / 再生医療 / プログラミング / 直接誘導
Outline of Final Research Achievements

From this research, we are searching for an efficient method of gene transfer from fibroblasts to myocardial infarction. In this study, we are searching for a method of efficient gene transfer from fibroblast cells to myocardial infarction cells. We are conducting research on the direct creation of cardiac muscle by introducing cardiac muscle-inducing genes into cardiac fibroblasts other than cardiac muscle.
In this study, we are also focusing on Zhang's cardiomyopathy and Fabry's transmissible cardiomyopathy to create constructs that can improve direct myocardial induction.

Academic Significance and Societal Importance of the Research Achievements

本研究では、単に心筋梗塞だけではなく、張型心筋症やファブリー病の伝性心筋症にも注目をして、心筋直接誘導が改善できることを目標として、条件検討を行っている。
その結果により、遺伝性の心筋症の患者に対しても、細胞移植を必要としない新しい心筋再生方法を確立することが期待できる。
よって、この心筋直接リプログラミングによる心筋再生技術は、iPS細胞誘導心筋細胞移植とは異なる、再生医療への用途が期待できるようになる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart2021

    • Author(s)
      Isomi Mari、Sadahiro Taketaro、Yamakawa Hiroyuki、Fujita Ryo、Yamada Yu、Abe Yuto、Murakata Yoshiko、Akiyama Tatsuya、Shu Tsugumine、Mizukami Hiroaki、Fukuda Keiichi、Ieda Masaki
    • Journal Title

      Circulation

      Volume: 143 Issue: 21 Pages: 2123-2125

    • DOI

      10.1161/circulationaha.120.052799

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac regeneration by direct reprogramming in this decade and beyond2021

    • Author(s)
      Yamakawa Hiroyuki、Ieda Masaki
    • Journal Title

      Inflammation and Regeneration

      Volume: 41 Issue: 1

    • DOI

      10.1186/s41232-021-00168-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside.2021

    • Author(s)
      Yamakawa H, Kato TS, Noh JY, Yuasa S, Kawamura A, Fukuda K, Aizawa Y.
    • Journal Title

      Front Physiol.

      Volume: 12 Pages: 606931-606931

    • DOI

      10.3389/fphys.2021.606931

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stem Cell Aging in Skeletal Muscle Regeneration and Disease2020

    • Author(s)
      Yamakawa Hiroyuki、Kusumoto Dai、Hashimoto Hisayuki、Yuasa Shinsuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 5 Pages: 1830-1830

    • DOI

      10.3390/ijms21051830

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming2019

    • Author(s)
      Muraoka Naoto、Nara Kaori、Tamura Fumiya、Kojima Hidenori、Yamakawa Hiroyuki、Sadahiro Taketaro、Miyamoto Kazutaka、Isomi Mari、Haginiwa Sho、Tani Hidenori、Kurotsu Shota、Osakabe Rina、Torii Satoru、Shimizu Shigeomi、Okano Hideyuki、Sugimoto Yukihiko、Fukuda Keiichi、Ieda Masaki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 674-674

    • DOI

      10.1038/s41467-019-08626-y

    • NAID

      120007128245

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 先天代謝異常症の成人移行支援(内科専門医の立場より)2021

    • Author(s)
      山川裕之
    • Organizer
      第62回 日本先天性代謝異常学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 女性ファブリー病における低心機能の患者の管理と、地域連携および在宅医療への導出方法2021

    • Author(s)
      山川裕之
    • Organizer
      第25回 日本心不全学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 我が国における在宅酵素補充療法の実現に向けての提言2021

    • Author(s)
      山川裕之
    • Organizer
      厚生労働省難治性疾患政策研究事業 ライソゾーム病・ペルオキシソーム病における良質かつ適切な医療の実現に向けた体制の構築とその実装に関する研究班
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 心筋症の鑑別 ファブリー病2020

    • Author(s)
      山川裕之
    • Organizer
      第24回 日本心不全学会 学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] マルチモダリティーを用いた心臓病理の解釈 ミクロレベル編・マクロレベル編2020

    • Author(s)
      山川裕之
    • Organizer
      第24回 日本心不全学会 学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] A case of myeloma cast nephropathy complicated by Fabry disease after withdrawal from dialysis2020

    • Author(s)
      Hiroyuki Yamakawa
    • Organizer
      WORLDSymposium 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fabry disease has been found by using of the tumor mutational burden analysis of 3000 Japanese cancer genimis using whole genome exome and targeted gene panel seqencing:Project Hightech Omics-based Patient Evaluation (Project HOPE) (2/2019

    • Author(s)
      Hiroyuki YAMAKAWA
    • Organizer
      WORLDSymposim 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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