| Project/Area Number |
18K08116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
富田 英 昭和大学, 医学部, 特任教授 (60180171)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 経皮的肺動脈弁留置術 / 先天性心疾患 / ファロー四徴症 / カテーテル治療 / 3Dプリンティング / ステント / カテーテルインターベンション / 3Dプリンター / 肺動脈弁逆流 / 経皮的肺動脈弁置換術 / 心臓MRI / 心臓CT / 立体模型 / 成人先天性心疾患 |
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| Outline of Final Research Achievements |
Pulmonary artery regurgitation was evaluated by echocardiography and cardiac MRI in postoperative patients with tetralogy of Fallot who had pulmonary valve regurgitation. We screened patients who needed re-intervention according to the criteria for pulmonary valve replacement. Cardiac CT was performed on the patients who were judged to be indicated, a 3D stereoscopic model was created based on the image data, and the morphology of the right ventricular outflow tract and pulmonary artery was evaluated. Evaluation of the right ventricular outflow tract was possible by this method, and there were some cases that could be applied to the simulation of stent implantation. This year, transcatheter pulmonary valve implantation was actually approved in Japan. For cases considered to be indicated for this treatment, our diagnostic imaging strategy may be useful for preoperative planning.
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| Academic Significance and Societal Importance of the Research Achievements |
経皮的肺動脈弁留置術の早期導入は患者の予後を大きく改善し、医療費の抑制にもつながり社会的にも有用であると考える。しかし、潜在的に存在する本治療の適応患者に関する国内のデータは皆無で，従来の画像診断のみでは評価することは困難である． 3Dプリント技術は本邦においては耳鼻科、整形外科、脳神経外科領域では既に実用化されているが、先天性心疾患診療分野では未開拓であり、かつ本研究の分野への応用は特に有用性が高い。本研究は本邦への経皮的肺動脈弁留置術早期導入に向けた基礎データの作成，医学研究を行う上での重要なデータとなる。
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