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Eucidation of signaling by Cpeptide and application for cardiovascular disease

Research Project

Project/Area Number 18K08120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionNational Defense Medical College

Principal Investigator

Ido Yasuo  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 内科学, 助教 (50814133)

Co-Investigator(Kenkyū-buntansha) 足立 健  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 内科学, 教授 (50231931)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsC-peptide / Doxorubicin / Autophagy / Nrf2 / High fat diet / type 2 diabetes / Erf2 / C-ペプチド / 糖尿病 / AMP キナーゼ
Outline of Final Research Achievements

In this project, we aimed to elucidate the signal transduction by C-peptide and the effects on type 2 diabetes model and Doxorubicin cardiopathy. In cell culture study, C-peptide elicited selective autophagy and accumulation of Nrf2 in nucleus, and subsequent increase in Nfr2 target gene expression. In the rat and mouse, administration of C-pepted caused increases in Nff2 induced genes such as Pdg, IDH1, NQO1 and SXN1. C-peptide also prevented Doxurubicin-induced cardiomyocyte apotheosis. However, the effects on type 2 diabetes model was not observed.

Academic Significance and Societal Importance of the Research Achievements

本研究はインスリンと共に分泌されるペプチドの活性と病気への応用について研究したものである。研究結果としてはペプチドはオートファジーと呼ばれる系を活性化することにより、ストレス耐性を増加させることがわかった。実際、抗癌剤による心臓障害の副作用マウスモデルでは、このペプチドにより心筋細胞のダメージが軽減されることがわかった。2型糖尿病への効果を検討してみたが、このモデルでは期待できる効果は得られなかった。
この研究はこのペプチドの効果機序を解明したことともに、疾病への応用への道が一つ明らかになった。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2020

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Journal Article] Impaired nicotinamide adenine dinucleotide (NAD) metabolism in diabetes and diabetic tissues: Implications for nicotinamide‐related compound treatment.2020

    • Author(s)
      Fan Lan, Jose M Cacicedo, Yasuo Ido
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 11 Issue: 6 Pages: 250-260

    • DOI

      10.1111/jdi.13303

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by Sirt1 knock-down: a pivotal role of LKB1 in cellular aging2020

    • Author(s)
      Fan Lan, Yan Lin, Zhenfeng Gao, Jose M Cacicedo, Karen Weikel, Yasuo Ido
    • Journal Title

      Aging (Albany NY)

      Volume: 12 Issue: 19 Pages: 18942-18956

    • DOI

      10.18632/aging.104052

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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