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Establishment of a histopathological diagnostic method for detecting high-risk patients with acute coronary syndrome

Research Project

Project/Area Number 18K08123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionUniversity of Miyazaki

Principal Investigator

Nishihira Kensaku  宮崎大学, 医学部, 研究員 (60736312)

Co-Investigator(Kenkyū-buntansha) 植田 初江  国立研究開発法人国立循環器病研究センター, 病院, 客員研究員 (40522983)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords急性冠症候群 / 循環器病学 / 動脈硬化 / 循環器病
Outline of Final Research Achievements

We investigated the histopathological finding of materials obtained during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and evaluated the relationship between the histopathological finding and clinical features. Older thrombus found in aspirated coronary material was associated with impaired myocardial reperfusion and was an independent predictor of poor outcomes in patients with ACS. In the histopathological analysis, fibrin and von Willebrand factor on ruptured sites were major adhesive molecules.
Moreover, in the process of this study, we discovered the presence of oxidized low-density lipoprotein at lipid-rich plaque in an ACS patients with heterozygous familial hypercholesterolemia.

Academic Significance and Societal Importance of the Research Achievements

急性冠症候群症例の血管内カテーテル治療時に得られる吸引血栓やアテレクトミーの標本を組織学的に評価することで、予後の悪い高リスク群の患者を抽出できる可能性がある。さらにはこれらの標本の組織学的検討から、急性冠症候群患者において、動脈硬化巣が破綻し血栓形成・血管閉塞していく過程には、フィブリンとフォンビルブラント因子が重要な役割を担っていることが明らかとなり、これらを抑制することで病状悪化を抑制できる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report

Research Products

(9 results)

All 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] The feasibility and limitation of coronary computed tomographic angiography imaging to identify coronary lipid-rich atheroma in vivo: Findings from near-infrared spectroscopy analysis2021

    • Author(s)
      Kitahara Satoshi、Kataoka Yu、Miura Hiroyuki、Nishii Tatsuya、Nishimura Kunihiro、Noguchi Teruo、Yasuda Satoshi
    • Journal Title

      Atherosclerosis

      Volume: 322 Pages: 1-7

    • DOI

      10.1016/j.atherosclerosis.2021.02.019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of 1 month of intensive lipid-lowering therapy on plaque composition evaluated using near-infrared spectroscopy2021

    • Author(s)
      Nishihira K, Kuriyama N, Shibata Y.
    • Journal Title

      Eur Heart J Case Rep

      Volume: 5

    • DOI

      10.1093/ehjcr/ytaa569

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathological features of ruptured coronary plaque and thrombus interfaces: fibrin and von Willebrand factor as platelet scaffolds on rupture sites2021

    • Author(s)
      Yamashita A, Nishihira K, Gi T, Maekawa K, Hatakeyama K, Horiuchi S, Wada K, Shibata Y, Asada Y.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 121 Pages: 234-241

    • DOI

      10.1055/s-0040-1716539

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In-stent restenosis following third-generation sirolimus-eluting stent implantation: first report analysed from imaging modalities and histopathological findings2020

    • Author(s)
      Yoshioka G, Nishihira K, Asada Y, Node K.
    • Journal Title

      Eur Heart J

      Volume: 41 Pages: 1707-1707

    • DOI

      10.1093/eurheartj/ehaa142

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of a Rapidly Progressing Lipid-Rich Plaque Causing No-Reflow Phenomenon During Percutaneous Coronary Intervention ― Insights From Near-Infrared Spectroscopy and Histopathology ―2020

    • Author(s)
      Honda Yasuhiro, Nishihira Kensaku, Kuriyama Nehiro, Yamashita Atsushi, Asada Yujiro, Shibata Yoshisato.
    • Journal Title

      Circ Rep

      Volume: 2 Issue: 1 Pages: 71-72

    • DOI

      10.1253/circrep.cr-19-0107

      10.1253/circrep.CR-19-0107

    • NAID

      130007784337

    • ISSN
      2434-0790
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of oxidized low-density lipoprotein at lipid-rich plaque in a ST-segment elevation myocardial infarction case with heterozygous familial hypercholesterolaemia: insights from near-infrared spectroscopy and histopathological analysis.2019

    • Author(s)
      Nishihira Kensaku, Yamashita Atsushi, Kataoka Yu, Shibata Yoshisato, Asada Yujiro
    • Journal Title

      European Heart Journal Cardiovascular Imaging

      Volume: 20 Pages: 1316-1316

    • DOI

      10.1093/ehjci/jez156

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Indoleamine 2,3-dioxygenase 1 in coronary atherosclerotic plaque enhances tissue factor expression in activated macrophages2018

    • Author(s)
      Watanabe Yuki、Koyama Shohei、Yamashita Atsushi、Matsuura Yunosuke、Nishihira Kensaku、Kitamura Kazuo、Asada Yujiro
    • Journal Title

      Res Pract Thromb Haemost

      Volume: 2 Pages: 726-735

    • DOI

      10.1002/rth2.12128

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The limitation of computed tomographic coronary angiography imaging to identify coronary lipid-rich atheroma in vivo: insights from computed tomographic coronary angiography and near-infrared spectroscopy analysis2019

    • Author(s)
      Kitahara S, Kataoka Y, Miura H, Honda S, Fujino M, Hosoda H, Nakao K, Yoneda S, Otsuka F, Kanaya T, Nishihira K, Asaumi Y, Noguchi T, Yasuda S
    • Organizer
      AHA2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between thrombus age in aspirated coronary material and mid-term major adverse cardiovascular events in patients with acute myocardial infarction2018

    • Author(s)
      Kensaku Nishihira, Yoshisato Shibata, Atsushi Yamashita, Nehiro Kuriyama, Yujiro Asada
    • Organizer
      XVIII International Symposium on Atherosclerosis
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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