Asessment at plaque vulnerability quantification with magnetic reonance and molecular imagings

• Project/Area Number: 18K08126
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Noguchi Teruo 国立研究開発法人国立循環器病研究センター, 病院, 副院長 (70505099)
• Co-Investigator(Kenkyū-buntansha): 浅海 泰栄 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20629315) ; 樋口 隆弘 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (30739850) ; 森田 佳明 国立研究開発法人国立循環器病研究センター, 病院, 医長 (80628074)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: プラーク / 冠動脈 / MRI / 画像診断 / 冠血流予備能比 / 冠動脈高信号プラーク / 動脈硬化

Outline of Final Research Achievements

Background: Between October 2012 and October 2016,141 patients with stable coronary artery disease underwent T1-weighted CMR imaging before PCI. A conventional 2-dimensional CMR plaque-to-myocardial signal intensity ratio (2D-PMR) and the newly developed 3-dimensional integral of PMR (3Di-PMR) were measured. 3Di-PMR was determined as the sum of PMRs above a threshold of > 1.0 for voxels in a target plaque. Results: Periprocedural myocardial infarction (pMI) following PCI was observed in 46 patients (33%). 3Di-PMR was significantly higher in patients with pMI than those without pMI. The optimal 3Di-PMR cutoff value for predicting pMI was 51 PMR*mm3 and the area under the receiver operating characteristic curve (0.753) was significantly greater than that for 2D-PMR (0.683, P = 0.015). Conclusions: 3Di-PMR coronary assessment facilitates risk stratification for pMI after elective PCI.

Academic Significance and Societal Importance of the Research Achievements

MRIを用いた3Di-PMRに基づく冠動脈プラークの非侵襲的な性状評価は、プラーク容積の概念を含み、冠動脈インターベンションを受ける患者のリスク層別化に臨床的に有益である。

Research Products

• [Journal Article] Suboptimal lipoprotein (a) control and residual plaque instability despite proprotein convertase subtilisin/kexin type 9 inhibitor use in heterozygous familial hypercholesterolaemia: insights from serial near-infrared spectroscopy imaging (2021)
  • Author(s): Imamoto Kazumasa、Kataoka Yu、Hosoda Hayato、Noguchi Teruo
  • Journal Title: European Heart Journal Volume: Apr 5 Issue: 22 Pages: 218-218
  • DOI: 10.1093/eurheartj/ehab218
  • Peer Reviewed
• [Journal Article] The feasibility and limitation of coronary computed tomographic angiography imaging to identify coronary lipid-rich atheroma in vivo: Findings from near-infrared spectroscopy analysis (2021)
  • Author(s): Kitahara Satoshi、Kataoka Yu、Miura Hiroyuki、Nishii Tatsuya、Nishimura Kunihiro、Noguchi Teruo、Yasuda Satoshi
  • Journal Title: Atherosclerosis Volume: 322 Pages: 1-7
  • DOI: 10.1016/j.atherosclerosis.2021.02.019
  • Peer Reviewed
• [Journal Article] In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations (2020)
  • Author(s): Kitahara Satoshi、Kataoka Yu、Sugane Hiroki、Otsuka Fumiyuki、Asaumi Yasuhide、Noguchi Teruo、Yasuda Satoshi
  • Journal Title: Cardiovascular Diagnosis and Therapy Volume: 10 Issue: 5 Pages: 1461-1479
  • DOI: 10.21037/cdt-20-238
  • Peer Reviewed / Open Access
• [Journal Article] Correction to: Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention (2020)
  • Author(s): Hosoda Hayato、Asaumi Yasuhide、Noguchi Teruo、Morita Yoshiaki、Kataoka Yu、Otsuka Fumiyuki、Nakao Kazuhiro、Fujino Masashi、Nagai Toshiyuki、Nakai Michikazu、Nishimura Kunihiro、Kono Atsushi、Komori Yoshiaki、Hoshi Tomoya、Sato Akira、Kawasaki Tomohiro、Izumi Chisato、Kusano Kengo、Fukuda Tetsuya、Yasuda Satoshi
  • Journal Title: Journal of Cardiovascular Magnetic Resonance Volume: 22 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s12968-020-00620-4
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention. (2020)
  • Author(s): Hosoda H, Asaumi Y, Noguchi T, Morita Y, Kataoka Y, Otsuka F, Nakao K, Fujino M, Nagai T, Nakai M, Nishimura K, Kono A, Komori Y, Hoshi T, Sato A, Kawasaki T, Izumi C, Kusano K, Fukuda T, Yasuda S.
  • Journal Title: J Cardiovasc Magn Reson. Volume: 22 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s12968-019-0588-6
  • NAID: 120007133004
  • Peer Reviewed / Open Access
• [Journal Article] Plaque erosion or coronary artery embolism? Findings from clinical presentation, optical coherence tomographic and histopathological analysis in a case with acute coronary syndrome. (2019)
  • Author(s): .Kitahara S, Kataoka Y, Otsuka F, Hosoda H, Asaumi Y, Noguchi T, Yasuda S.
  • Journal Title: Int J Cardiovasc Imaging Volume: 35 Pages: 1791-1792
  • Peer Reviewed / Open Access
• [Journal Article] Optical coherence tomography-verified morphological correlates of high-intensity coronary plaques on non-contrast T1-weighted magnetic resonance imaging in patients with stable coronary artery disease. (2018)
  • Author(s): Kanaya T, Noguchi T, Otsuka F, Asaumi Y, Kataoka Y, Morita Y, Miura H, Nakao K, Fujino M, Kawasaki T, Nishimura K, Inoue T, Narula J, Yasuda S.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 00 Issue: 1 Pages: 1-1
  • DOI: 10.1093/ehjci/jey035
  • Peer Reviewed / Open Access / Int'l Joint Research