| Project/Area Number |
18K08126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Noguchi Teruo 国立研究開発法人国立循環器病研究センター, 病院, 副院長 (70505099)
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| Co-Investigator(Kenkyū-buntansha) |
浅海 泰栄 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20629315)
樋口 隆弘 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (30739850)
森田 佳明 国立研究開発法人国立循環器病研究センター, 病院, 医長 (80628074)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | プラーク / 冠動脈 / MRI / 画像診断 / 冠血流予備能比 / 冠動脈高信号プラーク / 動脈硬化 |
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| Outline of Final Research Achievements |
Background: Between October 2012 and October 2016,141 patients with stable coronary artery disease underwent T1-weighted CMR imaging before PCI. A conventional 2-dimensional CMR plaque-to-myocardial signal intensity ratio (2D-PMR) and the newly developed 3-dimensional integral of PMR (3Di-PMR) were measured. 3Di-PMR was determined as the sum of PMRs above a threshold of > 1.0 for voxels in a target plaque. Results: Periprocedural myocardial infarction (pMI) following PCI was observed in 46 patients (33%). 3Di-PMR was significantly higher in patients with pMI than those without pMI. The optimal 3Di-PMR cutoff value for predicting pMI was 51 PMR*mm3 and the area under the receiver operating characteristic curve (0.753) was significantly greater than that for 2D-PMR (0.683, P = 0.015). Conclusions: 3Di-PMR coronary assessment facilitates risk stratification for pMI after elective PCI.
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| Academic Significance and Societal Importance of the Research Achievements |
MRIを用いた3Di-PMRに基づく冠動脈プラークの非侵襲的な性状評価は、プラーク容積の概念を含み、冠動脈インターベンションを受ける患者のリスク層別化に臨床的に有益である。
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