Understanding the pathogenesis of each responsible antigen and establishing new diagnostic methods in primary membranous nephropathy in Japan.
Project/Area Number |
18K08239
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53040:Nephrology-related
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
丸山 彰一 名古屋大学, 医学系研究科, 教授 (10362253)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 膜性腎症 / ネフローゼ症候群 / 責任抗原 / 自己抗体 / PLA2R / THSD7A |
Outline of Final Research Achievements |
The recent discovery of PLA2R and THSD7A as responsible antigens for primary membranous nephropathy (pMN) in adults has updated the disease concept, suggesting that pMN may be classified into subtypes by responsible antigen. In this study, we worked to elucidate the unknown responsible antigens, and to elucidate the pathogenesis and develop a novel diagnostic method using autoantibodies against PLA2R and THSD7A as indicators. We were unable to identify a novel responsible antigen specific to Japanese pMN patients. For PLA2R-related pMN, antibody concentration at diagnosis is an independent risk factor for worsening renal function, but epitope spreading did not correlate with disease activity. THSD7A-associated pMN had a similar pathogenetic mechanism as PLA2R-associated pMN, and diagnosis using autoantibodies as an indicator was useful.
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Academic Significance and Societal Importance of the Research Achievements |
近年、一次性膜性腎症の責任抗原の一部が明らかになり、抗原染色や血中自己抗体測定に基づいた鑑別・病勢評価・予後予測ができるようになりつつある。その一方で、一次性膜性腎症の病因となっているすべての責任抗原が同定されたわけではなく、とくに日本人一次性膜性腎症患者では責任抗原が不明なタイプの一次性膜性腎症が多く、既知の責任抗原であるPLA2RやTHSD7Aに関しても病態機序の理解や臨床実態の解明が不十分である。本研究は、これらの課題に対して科学的知見を補強するものであり、本邦のみならず世界中の一次性膜性腎症患者の診療に貢献するなどの学術的および社会的な意義を持っている。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Diffrences in peritoneal solute transport rates in peritoneal dialysis.2019
Author(s)
Asano M, Ishii T, Hirayama A, Mizuno M, Suzuki Y, Sakata F, Akiyama S, Maruyama S, Soga T, Kinashi H, Katsuno T, Ito Y.
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Journal Title
Clin Exp Nephrol.
Volume: 23
Issue: 1
Pages: 122-134
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis2018
Author(s)
Arai H, Toda N, Kamimatsuse R, Nishioka K, Endo S, Akiyama S, Maruyama S, Matsubara T, Yokoi H, Yanagita M.
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Journal Title
Internal Medicine
Volume: 57
Issue: 19
Pages: 2873-2877
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2018-10-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey2018
Author(s)
Yu Hashimoto, Hidenori Ogata, Ryo Yamasaki, Takakazu Sasaguri, Senri Ko, Kenichiro Yamashita, Zhang Xu, Takuya Matsushita, Takahisa Tateishi, Shin'ichi Akiyama, Shoichi Maruyama, Akifumi Yamamoto, Jun-ichi Kira
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Journal Title
Frontiers in Neurology
Volume: 9
Pages: 997-997
DOI
Related Report
Peer Reviewed / Open Access
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