| Project/Area Number |
18K08248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
根東 義明 日本大学, 医学部, 教授 (00221250)
安藤 史顕 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教 (80804559)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腎髄質内層集合尿細管 / 水透過性 / 尿素透過性 / V2受容体 / 先天性腎性尿崩症 / 髄質内層集合管 / 水・尿素透過性 / タンパク質キナーゼAアンカータンパク質 / タンパク質キナーゼA |
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| Outline of Final Research Achievements |
I planned the following experiments. I dissect inner medullary collecting duct from the mouse kidney and then I will confirm whether protein kinase A anchor protein and protein kinase A affect to the water and urea permeability of this tubule using in vitro microperfusion study. However, it was unexpectedly difficult. I decided to do an alternative experiment using immortal cells. But some troubles happened when I thawed the frozen cells. Finally, I could not produce any research results.
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| Academic Significance and Societal Importance of the Research Achievements |
今回は、研究計画作成時に想定した研究成果が得られなかったため、学術的意義や社会的意義はない。
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