| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In short-term aldosterone administration experiments, renal tubule-specific LSD1 knockout mice (KspLSD1-KO) showed a significantly stronger increase in the expression of ENaCα than control mice, suggesting increased aldosterone sensitivity. KspLSD1-KO mice showed a significant increase in blood pressure compared to control mice, which disappeared after administration of MR antagonist (spironolactone). Strong fibrosis was observed in both groups, but was suppressed by spironolactone to the same extent as in the normal diet; there was a strong tendency toward fibrosis in KspLSD1-KO, suggesting increased aldosterone sensitivity.
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