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Elucidation of the role of glycosaminoglycan in cutaneous inflammation of psoriasis and development of new therapies

Research Project

Project/Area Number 18K08282
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionEhime University

Principal Investigator

Muto Jun  愛媛大学, 医学部附属病院, 講師 (30338131)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乾癬 / ヒアルロン酸 / 自然免疫 / 樹状細胞 / グリコサミノグリカン
Outline of Final Research Achievements

Hyaluronic acid, which is abundant in the skin and is the main glycosaminoglycan that constitutes the extracellular matrix, plays a crucial role in inflammation in the skin's innate immunity, especially in the regulation of dendritic cell function. In this study, we investigated the effect of hyaluronan degradation on the pathophysiology of psoriasis. Using a model of imiquimod-induced psoriasis using hyaluronidase 1 overexpressing mice, the effects of hyaluronan degrading enzyme on skin inflammation were investigated. Furthermore, the involvement of hyaluronan degradation in the pathophysiology of psoriasis were investigated by in vitro experiments using dendritic cells.
In the future, we will develop a new treatment method targeting hyaluronic acid decomposition and create it for clinical application.

Academic Significance and Societal Importance of the Research Achievements

乾癬は代表的な炎症性角化症だが根本的な原因は不明である。今回、我々は乾癬の皮膚病変部においてヒアルロン酸が高発現して沈着していることを確認した。乾癬初期に重要な役割を果たす樹状細胞を用いた実験では、ヒアルロン酸処理で乾癬の初期の炎症を司るサイトカインを上昇させることを明らかにした。また、マウスを用いた実験で、ヒアルロン酸分解が、乾癬モデルマウスの炎症を有意に抑制することがわかった。以上より、ヒアルロン酸の分解により乾癬の炎症を修飾することができることが分かったため、今後ヒアルロン酸分解をターゲットとした新規治療法を開発して臨床応用へと展開したい。

Report

(3 results)
  • 2021 Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2019

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Emerging evidence for the essential role of hyaluronan in cutaneous biology.2019

    • Author(s)
      Muto J, Sayama K, Gallo RL, Kimata K.
    • Journal Title

      J Dermatol Sci.

      Volume: - Issue: 1 Pages: 190-195

    • DOI

      10.1016/j.jdermsci.2019.01.009

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Cutaneous degradation of hyaluronan induces suppressive effect to chronic allergic dermatitis.2019

    • Author(s)
      Jun Muto, Daisuke Watanabe, Richard L. Gallo, Koji Sayama
    • Organizer
      24rd World Congress of Dermatology (第24回世界皮膚科学会)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2024-12-25  

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