Exploration for immunoregulatory microRNAs based on genetic polymorphism associated with hematopoietic stem cell transplantation

• Project/Area Number: 18K08343
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Aichi Medical University
• Principal Investigator: Takami Akiyoshi 愛知医科大学, 医学部, 教授 (80324078)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 機能的遺伝子多型 / 造血幹細胞移植 / 遺伝子多型 / マイクロRNA / 免疫制御 / 造血細胞移植

Outline of Final Research Achievements

In this study, the functional roles of immunomodulatory gene polymorphisms in the 5’-untranslated region (NLRP3, ADMTS13, UNC93B1, HO-1), which the principal investigator has previously shown affect survival outcomes after allogeneic hematopoietic stem cell transplantation, were demonstrated. In particular, it was found that the G and C alleles in the NLRP3 rs10754558 (G > C) have high inducibility of NLRP3 / IL-1b and low inducibility of NLRP3 / IL-1b, respectively. In addition, allogeneic hematopoietic stem cell transplant recipients with the NLRP3 rs10754558 G allele were suggested to have increased mortality from transplant-related complications due to their high IL-1b inducibility. These results will also lead to the development of new targeted therapies for solid cancers, autoimmune diseases, and severe infectious diseases in which immunomodulatory gene polymorphisms are involved in their onset and progression of diseases.

Academic Significance and Societal Importance of the Research Achievements

同種造血幹細胞移植は白血病など血液難病の根治を期待して行われる。しかし、重症感染症や拒絶反応、再発のため、長期生存率は50%にとどまる。本研究において、下流非翻訳領域の機能性免疫調整遺伝子多型を制御することにより、同種造血幹細胞の成功率が飛躍的に高まる可能性が示された。さらに今回の研究成果は、同種造血幹細胞移植にとどまらず、疾患の発症や進展に免疫調整遺伝子多型が関与する固形がんや自己免疫疾患、重症感染症に対する新規標的治療法開発への波及効果も期待される。

Research Products

• [Journal Article] Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia (2022)
  • Author(s): Harada Kaito、Mizuno Shohei、Yano Shingo、Takami Akiyoshi、Ishii Hiroto、Ikegame Kazuhiro、Najima Yuho、Kako Shinichi、Ashida Takashi、Shiratori Souichi、Ota Shuichi、Onizuka Makoto、Fukushima Kentaro、Fukuda Takahiro、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: Annals of Hematology Volume: 101 Issue: 3 Pages: 643-653
  • DOI: 10.1007/s00277-021-04731-5
  • Peer Reviewed
• [Journal Article] Cytotoxicity of Callerya speciosa Fractions against Myeloma and Lymphoma Cell Lines (2022)
  • Author(s): Lam Vu Quang、Anh La Hoang、Quan Nguyen Van、Xuan Tran Dang、Hanamura Ichiro、Uchino Kaori、Karnan Sivasundaram、Takami Akiyoshi
  • Journal Title: Molecules Volume: 27 Issue: 7 Pages: 2322-2322
  • DOI: 10.3390/molecules27072322
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of a 365?nm Ultraviolet A1 light Emitting Diode (UVA1‐LED) in <i>in?vitro</i> Extracorporeal Photopheresis (2022)
  • Author(s): Maeda Akira、Yamamoto Riho、Mizuno Shohei、Miki Shigeichiro、Sakamoto Yasuhiro、Kogata Shuhei、Toyama Chiyoshi、Sato Kazuki、Okamatsu Chizu、Ando Takanori、Iida Minako、Watsuji Toru、Sato Toshinobu、Miyagawa Shuji、Okuyama Hiroomi、Takami Akiyoshi、Kodera Yoshitaka
  • Journal Title: Photochemistry and Photobiology Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1111/php.13613
  • Peer Reviewed
• [Journal Article] Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica, Zanthoxylum rhetsa, and Michelia tonkinensis (2022)
  • Author(s): Quan Nguyen Van、Anh La Hoang、Lam Vu Quang、Takami Akiyoshi、Teschke Rolf、Khanh Tran Dang、Xuan Tran Dang
  • Journal Title: Molecules Volume: 27 Issue: 3 Pages: 774-774
  • DOI: 10.3390/molecules27030774
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autologous hematopoietic cell transplantation for myeloma patients with hepatitis B virus or hepatitis C virus in the era of novel agents (2022)
  • Author(s): Mizuno Shohei、Takami Akiyoshi、Takamatsu Hiroyuki、Hanamura Ichiro、Shimazu Yutaka、Hangaishi Akira、Tsukada Nobuhiro、Kako Shinichi、Kikuchi Taku、Ota Shuichi、Shimizu Hiroaki、Iida Shinsuke、Yoshioka Satoshi、Sawa Masashi、Fukuda Takahiro、Kanda Yoshinobu、Atsuta Yoshiko、Kawamura Koji
  • Journal Title: Bone Marrow Transplantation Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1038/s41409-022-01640-7
  • Peer Reviewed
• [Journal Article] Successful preventive treatment with cyclosporine in a patient with relapsed/refractory immune-mediated thrombotic thrombocytopenic purpura: a case report and review of the literature (2022)
  • Author(s): Uchino Kaori、Sakai Kazuya、Shinohara Saki、Matsuhisa Akifumi、Iida Yusuke、Nakano Yuta、Matsumura Saori、Kanasugi Jo、Takasugi Soichi、Nakamura Ayano、Horio Tomohiro、Murakami Satsuki、Mizuno Shohei、Yamamoto Hidesuke、Hanamura Ichiro、Matsumoto Masanori、Takami Akiyoshi
  • Journal Title: International Journal of Hematology Volume: 1 Issue: 2 Pages: 1-10
  • DOI: 10.1007/s12185-022-03319-7
  • Peer Reviewed
• [Journal Article] Effects of In Vitro Digestion on Anti-α-Amylase and Cytotoxic Potentials of Sargassum spp. (2022)
  • Author(s): Un Sovannary、Quan Nguyen Van、Anh La Hoang、Lam Vu Quang、Takami Akiyoshi、Khanh Tran Dang、Xuan Tran Dang
  • Journal Title: Molecules Volume: 27 Issue: 7 Pages: 2307-2307
  • DOI: 10.3390/molecules27072307
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation (2021)
  • Author(s): Espinoza J. Luis、Kamio Kosuke、Lam Vu Quang、Takami Akiyoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 21 Pages: 11845-11845
  • DOI: 10.3390/ijms222111845
  • Peer Reviewed / Open Access
• [Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia (2021)
  • Author(s): Karnan Sivasundaram、Hanamura Ichiro、Uchino Kaori、Murakami Satsuki、Wahiduzzaman Md、Quang Vu Lam、Rahman Md Lutfur、Hasan Muhammad Nazmul、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Yoshikawa Kazuhiro、Suzuki Susumu、Ueda Ryuzo、Ejiri Masayuki、Hosokawa Yoshitaka、Takami Akiyoshi
  • Journal Title: Cell Death Discovery Volume: 7 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41420-021-00446-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synergistic Effects of Venetoclax and Daratumumab on Antibody-Dependent Cell-Mediated Natural Killer Cytotoxicity in Multiple Myeloma (2021)
  • Author(s): Nakamura Ayano、Suzuki Susumu、Kanasugi Jo、Ejiri Masayuki、Hanamura Ichiro、Ueda Ryuzo、Seto Masao、Takami Akiyoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 19 Pages: 10761-10761
  • DOI: 10.3390/ijms221910761
  • Peer Reviewed / Open Access
• [Journal Article] Immunological and Preventive Effects of Hochuekkito and Kakkonto Against Coronavirus Disease in Healthcare Workers: A Retrospective Observational Study (2021)
  • Author(s): Ogawa-Ochiai Keiko、Ishikawa Hideki、Li Hongyang、Vu Quang Lam、Kimoto Izumi、Takamura Mitsuyuki、Hongawa Tetsuya、Hane Yasuyuki、Suzuki Susumu、Okajima Masaki、Mori Keita、Ito Masanori、Takami Akiyoshi
  • Journal Title: Frontiers in Pharmacology Volume: 12 Pages: 1-10
  • DOI: 10.3389/fphar.2021.766402
  • Peer Reviewed / Open Access
• [Journal Article] Primary cutaneous methotrexate-associated B-cell lymphoproliferative disorders other than EBV-positive mucocutaneous ulcer: clinical, pathological, and immunophenotypic features (2021)
  • Author(s): Satou Akira、Banno Shogo、Kohno Kei、Takahara Taishi、Takahashi Emiko、Nobata Hironobu、Iwagaitsu Shiho、Watanabe Daisuke、Hanamura Ichiro、Takami Akiyoshi、Ito Yasuhiko、Nakamura Shigeo、Tsuzuki Toyonori
  • Journal Title: Pathology Volume: - Issue: 5 Pages: 595-601
  • DOI: 10.1016/j.pathol.2020.10.019
  • Peer Reviewed / Open Access
• [Journal Article] Pretreatment Immature Platelet Fraction as a Surrogate of Reticulated Platelets Predicts the Response to Corticosteroids in Adults with Immune Thrombocytopenia (2021)
  • Author(s): Takami Akiyoshi、Mizuno Shohei、Nakamura Ayano、Kanasugi Jo、Yamamoto Hidesuke、Vu?Quang Lam、Nakagami Yuya、Nakano Yuta、Yamada Saki、Matsumura Saori、Takasugi Souichi、Uchino Kaori、Horio Tomohiro、Murakami Satsuki、Oohigashi Yuka、Nakayama Takayuki、Tani Hiroya、Enomoto Megumi、Hanamura Ichiro
  • Journal Title: Acta Haematologica Volume: 144 Issue: 3 Pages: 345-349
  • DOI: 10.1159/000510460
  • Peer Reviewed / Open Access
• [Journal Article] Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan (2021)
  • Author(s): Takami Akiyoshi、Watanabe Shinichiro、Tohyama Kaoru、On behalf of The Japanese Society for Laboratory Hematology Standardization Committee (JSLH-SC) and Joint Working Group of the JSLH and the Japanese Association of Medical Technologists (JWG-JSLH-JAMT).
  • Journal Title: International Journal of Hematology Volume: 114 Issue: 3 Pages: 373-380
  • DOI: 10.1007/s12185-021-03166-y
  • Peer Reviewed
• [Journal Article] Reference intervals of white blood cell parameters for healthy adults in japan (2021)
  • Author(s): Takami Akiyoshi、Watanabe Shinichiro、Tohyama Kaoru、The Japanese Society for Laboratory Hematology subcommittee on Standardization of Blood Cell Morphology (JSLH‐SBCM)
  • Journal Title: International Journal of Laboratory Hematology Volume: 43 Issue: 5 Pages: 948-958
  • DOI: 10.1111/ijlh.13486
  • Peer Reviewed
• [Journal Article] Cytopenia associated with copper deficiency (2021)
  • Author(s): Uchino Kaori、Quang Lam Vu、Enomoto Megumi、Nakano Yuta、Yamada Saki、Matsumura Saori、Kanasugi Jo、Takasugi Soichi、Nakamura Ayano、Horio Tomohiro、Murakami Satsuki、Goto Mineaki、Mizuno Shohei、Yamamoto Hidesuke、Watarai Masaya、Hanamura Ichiro、Takami Akiyoshi
  • Journal Title: eJHaem Volume: 2 Issue: 4 Pages: 729-737
  • DOI: 10.1002/jha2.278
  • Peer Reviewed / Open Access
• [Journal Article] Allogeneic hematopoietic cell transplantation efficacy in patients with Philadelphia chromosome-positive acute myeloid leukemia in complete remission (2021)
  • Author(s): Mizuno Shohei、Yanada Masamitsu、Kawamura Koji、Masuko Masayoshi、Uchida Naoyuki、Ozawa Yukiyasu、Iwato Koji、Ohashi Kazuteru、Ikegame Kazuhiro、Kim Sung-Won、Tanaka Masatsugu、Eto Tetsuya、Kanda Yoshinobu、Fukuda Takahiro、Atsuta Yoshiko、Yano Shingo、Takami Akiyoshi
  • Journal Title: Bone Marrow Transplantation Volume: 56 Issue: 1 Pages: 232-242
  • DOI: 10.1038/s41409-020-01011-0
  • Peer Reviewed
• [Journal Article] Allogeneic Hematopoietic Cell Transplantation for Adolescent and Young Adult Patients with Acute Myeloid Leukemia (2021)
  • Author(s): Mizuno Shohei、Takami Akiyoshi、Kawamura Koji、Arai Yasuyuki、Kondo Tadakazu、Kawata Takahito、Uchida Naoyuki、Marumo Atsushi、Fukuda Takahiro、Tanaka Masatsugu、Ozawa Yukiyasu、Yoshida Shuro、Ota Shuichi、Takada Satoru、Sawa Masashi、Onizuka Makoto、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: Transplantation and Cellular Therapy Volume: 27 Issue: 4 Pages: 314.e1-314.e10
  • DOI: 10.1016/j.jtct.2020.12.013
  • Peer Reviewed
• [Journal Article] Comparison of Transplantation Outcomes after Foscarnet and Ganciclovir Administration as First-Line Anti-Cytomegalovirus Preemptive Therapy (2021)
  • Author(s): Miyao K, Terakura S, Ozawa Y, Sawa M, Kohno A, Kasahara S, Iida H, Ino K, Kusumoto S, Kasai M, Takami A, Kurahashi S, Kajiguchi T, Morishita T, Nishida T, Murata M; Nagoya Blood and Marrow Transplantation Group.
  • Journal Title: Transplant Cell Ther Volume: 27(4) Issue: 4 Pages: 342.e1-342.e10
  • DOI: 10.1016/j.jtct.2020.12.012
  • Peer Reviewed
• [Journal Article] Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. (2021)
  • Author(s): Uchino K, Vu Quang L, Mizuno S, Horio T, Yamamoto H, Hanamura I, Kodera Y, Luis Espinoza J, Onizuka M, Kashiwase K, Morishima Y, Fukuda T, Doki N, Miyamura K, Mori T, Morishita E, Nakao S, Takami A
  • Journal Title: Genes and Immunity Volume: 24 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41435-021-00122-y
  • Peer Reviewed / Open Access
• [Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia (2021)
  • Author(s): Hanamura, I. Karnan, S. Ota, A. Takasugi, S. Nakamura, A. Takahashi, M. Uchino, K. Murakami, S. Wahiduzzaman, M. Quan, L.V. Rahman, L. Hasanm M. Hyodo, t. Konishi, H. Tsuzuki, S. Yoshikawa, K. Suzuki, S. Ueda, R. Ejiri, M. Hosokawa, Y. Takami, A.
  • Journal Title: Cell Death Discovery Volume: 1 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Antioxidant, Anti-tyrosinase, Anti-α-amylase, and Cytotoxic Potentials of the Invasive Weed Andropogon virginicus (2020)
  • Author(s): Anh La Hoang、Quan Nguyen Van、Lam Vu Quang、Iuchi Yu、Takami Akiyoshi、Teschke Rolf、Xuan Tran Dang
  • Journal Title: Plants Volume: 10 Issue: 1 Pages: 69-69
  • DOI: 10.3390/plants10010069
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients (2020)
  • Author(s): Horio Tomohiro、Morishita Eriko、Mizuno Shohei、Uchino Kaori、Hanamura Ichiro、Espinoza J. Luis、Morishima Yasuo、Kodera Yoshihisa、Onizuka Makoto、Kashiwase Koichi、Fukuda Takahiro、Doki Noriko、Miyamura Koichi、Mori Takehiko、Nakao Shinji、Takami Akiyoshi
  • Journal Title: Cancers Volume: 12 Issue: 2 Pages: 424-437
  • DOI: 10.3390/cancers12020424
  • Peer Reviewed / Open Access
• [Journal Article] Pathological and Virological Studies of p16-Positive Oropharyngeal Carcinoma with a Good Response to Neoadjuvant Chemotherapy (2020)
  • Author(s): Inukai Daisuke、Kan Taichi、Yamanaka Shunpei、Okamoto Hiroki、Fujimoto Yasushi、Ito Takanori、Taniguchi Natsuki、Yamamoto Yuuki、Tsuzuki Toyonori、Takami Akiyoshi、Ogawa Tetsuya
  • Journal Title: Microorganisms Volume: 8 Issue: 10 Pages: 1497-1497
  • DOI: 10.3390/microorganisms8101497
  • Peer Reviewed / Open Access
• [Journal Article] Reduced-intensity stem cell transplantation for acute myeloid leukemia with fludarabine-based conditioning with intravenous busulfan versus melphalan (2020)
  • Author(s): Yamashita Takuya、Takami Akiyoshi、Uchida Naoyuki、Fukuda Takahiro、Eto Tetsuya、Shiratori Souichi、Ota Shuichi、Akasaka Takashi、Miyakoshi Shigesaburo、Kondo Tadakazu、Hidaka Michihiro、Kanda Junya、Atsuta Yoshiko、Yano Shingo
  • Journal Title: Bone Marrow Transplantation Volume: 55 Issue: 10 Pages: 1955-1965
  • DOI: 10.1038/s41409-020-0856-y
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia conducted in Japan during the past quarter century (2020)
  • Author(s): Yanada Masamitsu、Takami Akiyoshi、Yamasaki Satoshi、Arai Yasuyuki、Konuma Takaaki、Uchida Naoyuki、Najima Yuho、Fukuda Takahiro、Tanaka Masatsugu、Ozawa Yukiyasu、Ikegame Kazuhiro、Takanashi Minoko、Ichinohe Tatsuo、Okamoto Shinichiro、Atsuta Yoshiko、Yano Shingo
  • Journal Title: Annals of Hematology Volume: 99 Issue: 6 Pages: 1351-1360
  • DOI: 10.1007/s00277-020-04051-0
  • Peer Reviewed
• [Journal Article] Autologous hematopoietic cell transplantation for acute myeloid leukemia in adults: 25 years of experience in Japan (2020)
  • Author(s): Yanada M, Takami A, Mizuno S, Mori J, Chou T, Usuki K
  • Journal Title: Int J Hematol Volume: 111 Issue: 1 Pages: 93-102
  • DOI: 10.1007/s12185-019-02759-y
  • Peer Reviewed
• [Journal Article] Juvenile Hemochromatosis: A Case Report and Review of the Literature (2020)
  • Author(s): Takami Akiyoshi、Tatsumi Yasuaki、Sakai Katsuhisa、Toki Yasumichi、Ikuta Katsuya、Oohigashi Yuka、Takagi Junko、Kato Koichi、Takami Kazuhisa
  • Journal Title: Pharmaceuticals Volume: 13 Issue: 8 Pages: 195-195
  • DOI: 10.3390/ph13080195
  • Peer Reviewed / Open Access
• [Journal Article] Reply to the letter by Gaetano Loscocco, Secondary hemophagocytic lymphohistiocytosis, HScore and COVID-19 (2020)
  • Author(s): Takami Akiyoshi
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 1 Pages: 127-127
  • DOI: 10.1007/s12185-020-02896-9
  • Peer Reviewed
• [Journal Article] Possible role of low-dose etoposide therapy for hemophagocytic lymphohistiocytosis by COVID-19 (2020)
  • Author(s): Takami Akiyoshi
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 1 Pages: 122-124
  • DOI: 10.1007/s12185-020-02888-9
  • Peer Reviewed
• [Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells (2020)
  • Author(s): Ota Akinobu、Hanamura Ichiro、Karnan Sivasundaram、Inaguma Shingo、Takei Norio、Lam Vu Quang、Mizuno Shohei、Kanasugi Jo、Wahiduzzaman Md、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Ikeda Hiroshi、Takami Akiyoshi、Hosokawa Yoshitaka
  • Journal Title: Journal of Interferon & Cytokine Research Volume: 40 Issue: 8 Pages: 389-405
  • DOI: 10.1089/jir.2020.0111
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vivo tracking of transplanted macrophages with near infrared fluorescent dye reveals temporal distribution and specific homing in the liver that can be perturbed by clodronate liposomes (2020)
  • Author(s): Nishiwaki Satoshi、Saito Shigeki、Takeshita Kyosuke、Kato Hidefumi、Ueda Ryuzo、Takami Akiyoshi、Naoe Tomoki、Ogawa Mika、Nakayama Takayuki
  • Journal Title: PLOS ONE Volume: 15 Issue: 12 Pages: e0242488-e0242488
  • DOI: 10.1371/journal.pone.0242488
  • Peer Reviewed / Open Access
• [Journal Article] Potential role of Howell?Jolly bodies in identifying functional hyposplenism: a prospective single-institute study (2020)
  • Author(s): Nakagami Yuya、Uchino Kaori、Okada Hiroaki、Suzuki Kojiro、Enomoto Megumi、Mizuno Shohei、Yamamoto Hidesuke、Hanamura Ichiro、Nakayama Takayuki、Tani Hiroya、Takami Akiyoshi
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 4 Pages: 544-552
  • DOI: 10.1007/s12185-020-02925-7
  • Peer Reviewed
• [Journal Article] Combining T‐cell‐based immunotherapy with venetoclax elicits synergistic cytotoxicity to B‐cell lines in vitro (2020)
  • Author(s): Murakami Satsuki、Suzuki Susumu、Hanamura Ichiro、Yoshikawa Kazuhiro、Ueda Ryuzo、Seto Masao、Takami Akiyoshi
  • Journal Title: Hematological Oncology Volume: 38 Issue: 5 Pages: 705-714
  • DOI: 10.1002/hon.2794
  • Peer Reviewed / Open Access
• [Journal Article] Outcome and Risk Factors for Therapy-Related Myeloid Neoplasms Treated with Allogeneic Stem Cell Transplantation in Japan (2020)
  • Author(s): Kida Michiko、Usuki Kensuke、Uchida Naoyuki、Fukuda Takahiro、Katayama Yuta、Kondo Tadakazu、Eto Tetsuya、Matsuoka Ken-ichi、Matsuhashi Yoshiko、Ota Shuichi、Sawa Masashi、Miyamoto Toshihiro、Ichinohe Tatsuo、Kimura Takafumi、Atsuta Yoshiko、Takami Akiyoshi
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 26 Issue: 8 Pages: 1543-1551
  • DOI: 10.1016/j.bbmt.2020.04.004
  • Peer Reviewed
• [Journal Article] Uterine relapse of Philadelphia chromosome-negative acute lymphoblastic leukemia (2020)
  • Author(s): Kawano Noriaki、Maeda Tetsuo、Kawano Sayaka、Naghiro Yuri、Takami Akiyoshi、Tochigi Taro、Nakaike Takashi、Yamashita Kiyoshi、Kodama Takao、Marutsuka Kosuke、Sugimoto Yuka、Imamura Toshihiko、Mori Yasuo、Ochiai Hidenobu、Hidaka Tomonori、Shimoda Kazuya、Mashiba Koichi、Kikuchi Ikuo
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 60 Issue: 3 Pages: 103-107
  • DOI: 10.3960/jslrt.20016
  • NAID: 130007907555
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed
• [Journal Article] Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study (2020)
  • Author(s): Kawamura Kentaro、Fukumura Shinobu、Nikaido Koki、Tachi Nobutada、Kozuka Naoki、Seino Tsugumi、Hatakeyama Kingya、Mori Mitsuru、Ito Yoichi M.、Takami Akiyoshi、Hinotsu Shiro、Kuno Atsushi、Kawasaki Yukihiko、Horio Yoshiyuki、Tsutsumi Hiroyuki
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-020-77197-6
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• [Journal Article] Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells (2020)
  • Author(s): Kanasugi J, Hanamura I, Ota A, Karnan S, Vu LQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A
  • Journal Title: Cancer Science Volume: - Issue: 5 Pages: 999-999
  • DOI: 10.1111/cas.14386
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Natural killer cell function changes by the Japanese Kampo Medicine Juzentaihoto in General fatigue patients (2020)
  • Author(s): Ogawa-Ochiai Keiko、Katagiri Takamasa、Sato Yuki、Shirai Akiko、Ishiyama Ken、Takami Akiyoshi、Morishita Eriko
  • Journal Title: Advances in Integrative Medicine Volume: 999 Issue: 1 Pages: 999-999
  • DOI: 10.1016/j.aimed.2019.12.003
  • Peer Reviewed
• [Journal Article] Bicytopenia in Primary Lung Melanoma Treated with Nivolumab (2019)
  • Author(s): Takahashi Ayumu、Kubo Akihito、Mizuno Shohei、Kasai Kenji、Asai Nobuhiro、Yonezawa Toshiyuki、Kosaka Kenshi、Nishimura Masaki、Tanaka Hiroyuki、Yokoe Norihito、Tsuzuki Toyonori、Takami Akiyoshi、Yamaguchi Etsuro
  • Journal Title: Internal Medicine Volume: 58 Issue: 6 Pages: 827-831
  • DOI: 10.2169/internalmedicine.1011-18
  • NAID: 130007612113
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-03-15
  • Peer Reviewed / Open Access
• [Journal Article] Role of alternative donor allogeneic hematopoietic stem cell transplantation in patients with intermediate- or poor-risk acute myeloid leukemia in first complete remission (2019)
  • Author(s): Yano Shingo、Yokoyama Hiroki、Yanada Masamitsu、Mori Jinichi、Aoki Jun、Ohashi Kazuteru、Kanomori Heiwa、Ozawa Yuichiro、Sawa Masashi、Nakamae Hiroshisa、Eto Tetsuya、Ohta Shuichi、Tanaka Junji、Ichinohe Tatsuo、Atsuta Yoshiko、Takami Akiyoshi
  • Journal Title: Bone Marrow Transplantation Volume: 54 Issue: 12 Pages: 2004-2012
  • DOI: 10.1038/s41409-019-0571-8
  • Peer Reviewed
• [Journal Article] EBV-positive mucocutaneous ulcer arising in rheumatoid arthritis patients treated with methotrexate: Single center series of nine cases. (2019)
  • Author(s): Satou A, Banno S, Hanamura I, Takahashi E, Takahara T, Nobata H, Katsuno T, Takami A, Ito Y, Ueda R, Nakamura S, Tsuzuki T
  • Journal Title: Pathology International Volume: 69(1) Issue: 1 Pages: 21-28
  • DOI: 10.1111/pin.12745
  • Peer Reviewed
• [Journal Article] Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy. (2019)
  • Author(s): Nomoto H, Takami A, Espinoza JL, Onizuka M, Kashiwase K, Morishima Y, Fukuda T, Kodera Y, Doki N, Miyamura K, Mori T, Nakao S, Morishita E
  • Journal Title: Int J Mol Sci Volume: Jan 8;20(1) Issue: 1 Pages: 214-214
  • DOI: 10.3390/ijms20010214
  • Peer Reviewed / Open Access
• [Journal Article] A systematic literature review on the use of platelet transfusions in patients with thrombocytopenia (2019)
  • Author(s): Newland Adrian、Bentley Roy、Jakubowska Anna、Liebman Howard、Lorens Joanna、Peck-Radosavljevic Markus、Taieb Vanessa、Takami Akiyoshi、Tateishi Ryosuke、Younossi Zobair M.
  • Journal Title: Hematology Volume: 24 Issue: 1 Pages: 679-719
  • DOI: 10.1080/16078454.2019.1662200
  • Peer Reviewed
• [Journal Article] Efficacy and safety of autologous stem cell transplantation in patients aged ??65 years with multiple myeloma in the era of novel agents (2019)
  • Author(s): Mizuno Shohei、Kawamura Koji、Hanamura Ichiro、Sunami Kazutaka、Mori Takehiko、Nakamura Fumihiko、Iida Shinsuke、Nakazawa Hideyuki、Makita Masanori、Kako Shinichi、Sawa Masashi、Ueda Yasunori、Takahashi Hiroyuki、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Takamatsu Hiroyuki、Takami Akiyoshi
  • Journal Title: Bone Marrow Transplantation Volume: 54 Issue: 10 Pages: 1595-1604
  • DOI: 10.1038/s41409-019-0478-4
  • Peer Reviewed
• [Journal Article] Rationale for assessing the therapeutic potential of resveratrol in hematological malignancies (2019)
  • Author(s): Espinoza J. Luis、Kurokawa Yu、Takami Akiyoshi
  • Journal Title: Blood Reviews Volume: 33 Pages: 43-52
  • DOI: 10.1016/j.blre.2018.07.001
  • Peer Reviewed
• [Journal Article] Evaluation of a biosimilar granulocyte colony-stimulating factor for peripheral blood stem cell mobilization in Japanese healthy donors: a prospective study (2019)
  • Author(s): Sato K, Ishiyama K, Aoki G, Maruyama H, Tsuji N, Tanabe M, Takami A
  • Journal Title: Int J Hematol Volume: 110 Issue: 6 Pages: 648-53
  • DOI: 10.1007/s12185-019-02733-8
  • Peer Reviewed
• [Journal Article] Immunomodulatory and Metabolic Changes after Gnetin-C Supplementation in Humans. (2019)
  • Author(s): Nakagami Y, Suzuki S, Espinoza JL, Vu Quang L, Enomoto M, Takasugi S, Nakamura A, Nakayama T, Tani H, Hanamura I, Takami A
  • Journal Title: Nutrients Volume: 11 Issue: 6 Pages: 1403-1403
  • DOI: 10.3390/nu11061403
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reference guide for adult chronic neutropenia (2018)
  • Author(s): 横山 泰久、千葉 滋、日本医療研究開発機構・難治性疾患実用化研究事業「成人慢性好中球減少症の診療ガイドライン作成に向けた予後追跡調査」研究班、高見 昭良、森 康雄、佐藤 信也、鈴木 隆浩、五所 正彦、小原 直、宮﨑 泰司、赤司 浩一
  • Journal Title: Rinsho Ketsueki Volume: 59 Issue: 7 Pages: 845-857
  • DOI: 10.11406/rinketsu.59.845
  • NAID: 130007430620
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo (2018)
  • Author(s): Wahiduzzaman Md、Ota Akinobu、Karnan Sivasundaram、Hanamura Ichiro、Mizuno Shohei、Kanasugi Jo、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Takami Akiyoshi、Hosokawa Yoshitaka
  • Journal Title: Cancer Letters Volume: 433 Pages: 117-130
  • DOI: 10.1016/j.canlet.2018.06.027
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation for acute myeloid leukemia (2018)
  • Author(s): Takami, A
  • Journal Title: Int J Hematol Volume: 107 Issue: 5 Pages: 513-518
  • DOI: 10.1007/s12185-018-2412-8
  • Peer Reviewed
• [Journal Article] Guidelines based on scientific evidence for the application of platelet transfusion concentrates (2018)
  • Author(s): 高見 昭良
  • Journal Title: Rinsho Ketsueki Volume: 59 Issue: 10 Pages: 2349-2353
  • DOI: 10.11406/rinketsu.59.2349
  • NAID: 130007496576
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction (2018)
  • Author(s): Kurahashi, H., Takami, A., Murotani, K., Numoto, S. and Okumura, A.
  • Journal Title: Int J Hematol Volume: 107 Issue: 1 Pages: 105-111
  • DOI: 10.1007/s12185-017-2323-0
  • Peer Reviewed
• [Journal Article] Clinical evaluation of a novel and highly sensitive immunoassay for anti-hepatitis B core antigen using a fully automated immunochemical analyzer. (2018)
  • Author(s): Izumida K, Kaneko A, Takahashi K, Kusumoto S, Narita T, Takami A, Iida S, Aoyagi K, Tanaka Y.
  • Journal Title: Hepatol Res. Volume: 48 Issue: 13 Pages: 1081-1091
  • DOI: 10.1111/hepr.13229
  • Peer Reviewed
• [Journal Article] Infection Complications in Hematopoietic Stem Cells Transplant Recipients: Do Genetics Really Matter? (2018)
  • Author(s): Espinoza J. Luis、Wadasaki Yohei、Takami Akiyoshi
  • Journal Title: Frontiers in Microbiology Volume: 9 Pages: 1-11
  • DOI: 10.3389/fmicb.2018.02317
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Establishment and characterization of a novel vincristine-resistant diffuse large B-cell lymphoma cell line containing the 8q24 homogeneously staining region (2018)
  • Author(s): Mizuno S、Hanamura I、Ota Akinobu、Karnan S、Kanasugi J、Nakamura A、Takasugi S、Uchino Ki、Horio T、Goto、Murakami S、Gotou M、Yamamoto H、Watarai M、Shikami M、Hosokawa Y、Miwa H、Taniwaki M、Ueda R、Nitta M、Takami A
  • Journal Title: FEBS Open Bio Volume: 8 Issue: 12 Pages: 1977-1991
  • DOI: 10.1002/2211-5463.12538
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 肝炎ウィルス(HBV、HCV)感染を伴う多発性骨髄腫患者の自家造血細胞移植成績 (2021)
  • Author(s): 水野昌平、高見昭良、花村一朗、河村浩二、島津裕、半下石明、塚田信弘、賀古真一、菊池拓、太田秀一、土岐典子、飯田真介、吉岡聡、澤正吏、福田隆浩、神田善伸、熱田由子、高松博幸
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] メトトレキサート関連リンパ増殖性疾患（ホジキンリンパ腫）の検討 (2021)
  • Author(s): 村上五月, 坂野章吾, 佐藤啓, 花村一朗, 山本英督, 水野昌平, 堀尾知弘, 内野かおり, 高見昭良
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] 再発難治性血栓性血小板減少性紫斑病患者におけるシクロスポリンの有用性 (2021)
  • Author(s): 内野かおり 山田早紀 中野雄太 松村沙織 金杉丈 高杉壮一 中村文乃 村上五月 堀尾知弘 水野昌平 山本英督 花村一朗 酒井和哉 松本雅則 高見昭良
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] ベネトクラクスは BCL2 高発現の多発性骨髄腫細胞株に対するダラツムマブの抗体依存性細胞傷害活性を増強させる (2021)
  • Author(s): 中村文乃、鈴木進、瀬戸加大、高杉壮一、金杉丈、花村一朗、上田龍三、高見昭良
  • Organizer: 第46回日本骨髄腫学会学術集会
• [Presentation] 赤芽球癆を合併した血管免疫芽球性T細胞リンパ腫 (2021)
  • Author(s): 堀尾知弘 水野昌平 内野かおり 山本英督 村上五月 高杉壮一 中村文乃 金杉丈 松村沙織 中野雄太 花村一朗 高見昭良
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] 臨床血液・形態学入門 (2020)
  • Author(s): 高見昭良
  • Organizer: 日本検査血液学会学術集会
  • Invited
• [Presentation] Functional gene polymorphisms in hematopoietic stem cell transplantation (2019)
  • Author(s): Takami, A.
  • Organizer: 5th National Hematology And Blood Transfusion Congress, Vietnam
  • Int'l Joint Research / Invited
• [Presentation] HOMOZYGOUS I281T MUTATION IN HJV CAUSING INDOLENT JUVENILE HEMOCHROMATOSIS WITH A MIDDLE TO LATE ONSET (2019)
  • Author(s): Takami A.
  • Organizer: Annual Meeting of European Hematology Association
  • Int'l Joint Research
• [Presentation] DONOR UNC-93 HOMOLOG B1 GENETIC VARIATION PREDICTS SURVIVAL OUTCOMES AFTER UNRELATED BONE MARROW TRANSPLANTATION (2019)
  • Author(s): Uchino K, Takami A
  • Organizer: Annual Meeting of European Hematology Association
  • Int'l Joint Research
• [Presentation] Immunomodulatory and metabolic changes after Gnetin-C supplementation in humans (2018)
  • Author(s): Vu Quang L, Espinoza JL, Takami A
  • Organizer: 5th International Conference on Resveratrol and Health
  • Int'l Joint Research / Invited
• [Presentation] Reference Intervals for White Blood Cell Counts and the Neutrophil and Lymphocyte Differentials among Healthy Japanese Adults: A Multicenter Collaborative Study (2018)
  • Author(s): Takami A
  • Organizer: International Journal of Laboratory Hematology
  • Int'l Joint Research
• [Presentation] Initial Immature Platelet Fraction for Prediction of Response to Corticosteroids in Immune Thrombocytopenia (2018)
  • Author(s): Takami A
  • Organizer: International Journal of Laboratory Hematology
  • Int'l Joint Research