Enhancement of Intracellular Signaling in T Cell Receptor-transduced T Cells

• Project/Area Number: 18K08351
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Nagoya University
• Principal Investigator: Terakura Seitaro 名古屋大学, 医学部附属病院, 講師 (40625141)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 遺伝子導入T細胞療法 / アダプター分子 / Tリンパ球 / TCR遺伝子導入 / T細胞養子免疫療法 / 新規アダプター分子 / 遺伝子導入T細胞 / T細胞内シグナル / 遺伝子改変

Outline of Final Research Achievements

In this study, we attempted to develop a novel vector that enables gene transfer of TCR and adapter molecule (ATAM) into T cells by a single gene transfer. One virus vector method (1vv method) using all-in-one vector and two virus vector (2vv) method using two vectors used in the previous study showed that the expression of ATAM was about 3 times higher in 2vv method. The expression of ATAM was about 3-fold higher in the 2vv method. Comparison of the function of the TCR-T cells generated by the 2vv method showed that the cells generated by the 2vv method proliferated significantly better after antigen stimulation, and the intracellular signals after stimulation showed that the signals of phosphorylated Erk and p38 were significantly enhanced in the TCR-T cells generated by the 2vv method. The results showed that it is necessary to transfer three times more ATAM than TCR.

Academic Significance and Societal Importance of the Research Achievements

T細胞レセプター遺伝子と新規に開発したアダプター分子を１回の遺伝子導入によりT細胞内に遺伝子導入可能とする新規ベクターの開発を試みた。ひとつのベクターで遺伝し導入する1 virus vector法（1vv法)と二つのウイルスベクターを用いる方法 (2 virus vector法, 2vv法)を比較したところ、ウェスタンブロット法でも、フローサイト メトリー法でも2vv法でアダプター分子の発現が約3倍程度高く、2vv法で作成したTCR-Tの方が有意に抗原刺激後の増殖が有利であった。TCRよりも3倍以上多くのアダプター分子を遺伝子導入する必要があることが示された。

Research Products

• [Int'l Joint Research] Medical University of Vienna(オーストリア)
• [Journal Article] Comparison of immunosuppressant regimens in salvage cord blood transplantation for graft failure after allogeneic hematopoietic stem cell transplantation (2021)
  • Author(s): Harada K, Fuji S, Seo S, Uchida N, Kawakita T, Yano S, Ozawa Y, Yoshioka S, Onishi Y, Noguchi Y, Onizuka M, Matsuhashi Y, Kimura T, Ichinohe T, Atsuta Y, Terakura S, Nakasone H.
  • Journal Title: Bone Marrow Transplant Volume: 56(2) Issue: 2 Pages: 400-410
  • DOI: 10.1038/s41409-020-00999-9
  • Peer Reviewed
• [Journal Article] Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation. (2021)
  • Author(s): Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Suzuki S, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.
  • Journal Title: Stem Cells Transl Med. Volume: 10(4) Issue: 4 Pages: 542-553
  • DOI: 10.1002/sctm.20-0381
  • Peer Reviewed / Open Access
• [Journal Article] A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin. (2021)
  • Author(s): Nishida T, Kobayashi T, Sawa M, Masuda S, Shibasaki Y, Goto T, Fukuhara N, Fujii N, Ikegame K, Sugita J, Ikeda T, Kuwatsuka Y, Suzuki R, Najima Y, Doki N, Kato T, Inagaki Y, Utsu Y, Aotsuka N, Masuko M, Terakura S, Onishi Y, Maeda Y, Okada M, Teshima T, Murata M.
  • Journal Title: Annals of Hematology Volume: 100 Issue: 3 Pages: 743-752
  • DOI: 10.1007/s00277-020-04365-z
  • NAID: 120007147363
  • Peer Reviewed
• [Journal Article] Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia (2021)
  • Author(s): Terakura S, Kuwatsuka Y, Sugita J, Takahashi S, Ozawa Y, Ozeki K, Yoshioka S, Nakamae H, Kawakita T, Sawa M, Morishige S, Najima Y, Katsuoka Y, Sakaida E, Kouzai Y, Kimura T, Ichinohe T, Fukuda T, Atsuta Y, Murata M, Teshima T.
  • Journal Title: Int J Hematol Volume: - Issue: 6 Pages: 840-850
  • DOI: 10.1007/s12185-021-03097-8
  • Peer Reviewed / Open Access
• [Journal Article] Single Cord Blood Transplantation Versus Unmanipulated Haploidentical Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission. (2021)
  • Author(s): Konuma T, Kanda J, Yamasaki S, Harada K, Shimomura Y, Terakura S, Mizuno S, Uchida N, Tanaka M, Doki N, Ozawa Y, Nakamae H, Sawa M, Matsuoka KI, Morishige S, Maruyama Y, Ikegame K, Kimura T, Kanda Y, Ichinohe T, Atsuta Y, Yanada M.
  • Journal Title: Transplant Cell Ther. Volume: 27(4) Issue: 4 Pages: 334.e1-334.e11
  • DOI: 10.1016/j.jtct.2021.01.023
  • Peer Reviewed
• [Journal Article] Comparison of Transplantation Outcomes after Foscarnet and Ganciclovir Administration as First-Line Anti-Cytomegalovirus Preemptive Therapy (2021)
  • Author(s): Miyao K, Terakura S, Ozawa Y, Sawa M, Kohno A, Kasahara S, Iida H, Ino K, Kusumoto S, Kasai M, Takami A, Kurahashi S, Kajiguchi T, Morishita T, Nishida T, Murata M; Nagoya Blood and Marrow Transplantation Group.
  • Journal Title: Transplant Cell Ther Volume: 27(4) Issue: 4 Pages: 342.e1-342.e10
  • DOI: 10.1016/j.jtct.2020.12.012
  • Peer Reviewed
• [Journal Article] Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome (2020)
  • Author(s): Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Goto T, Kohno A, Ozeki K, Onishi Y, Fukuhara N, Fujii N, Yokoyama H, Kasai M, Iida H, Kanemura N, Endo T, Ago H, Onizuka M, Iyama S, Nawa Y, Nakamae M, Nagata Y, Kurahashi S, Tomiya Y, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M
  • Journal Title: Bone Marrow Transplantation Volume: -- Issue: 7 Pages: 1399-1409
  • DOI: 10.1038/s41409-020-0859-8
  • NAID: 120006891238
  • Peer Reviewed
• [Journal Article] Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies (2020)
  • Author(s): Imahashi Nobuhiko、Terakura Seitaro、Kondo Eisei、Kako Shinichi、Uchida Naoyuki、Kobayashi Hikaru、Inamoto Yoshihiro、Sakai Hitoshi、Tanaka Masatsugu、Ishikawa Jun、Kozai Yasuji、Matsuoka Ken-ichi、Kimura Takafumi、Fukuda Takahiro、Atsuta Yoshiko、Kanda Junya
  • Journal Title: Bone Marrow Transplantation Volume: 55 Issue: 11 Pages: 2098-2108
  • DOI: 10.1038/s41409-020-0905-6
  • Peer Reviewed
• [Journal Article] Staurosporine and venetoclax induce the caspase- dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. (2020)
  • Author(s): Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
  • Journal Title: Biomed Pharmacother. Volume: 128 Pages: 110330-110330
  • DOI: 10.1016/j.biopha.2020.110330
  • Peer Reviewed / Open Access
• [Journal Article] Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory Hodgkin lymphoma: a multicenter retrospective study (2020)
  • Author(s): Ito Ayumu、（15名）、Takemura Tomonari、Terakura Seitaro、Iida Hiroatsu、Nakamae Mika、Higuchi Kohei、Tamura Shinobu、Yoshioka Satoshi、Togitani Kazuto、Kawano Noriaki、Suzuki Ritsuro、Suzumiya Junji、Izutsu Koji、Teshima Takanori、Fukuda Takahiro
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 5 Pages: 674-689
  • DOI: 10.1007/s12185-020-02960-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Updated Comparison of 7/8 HLA Allele-Matched Unrelated Bone Marrow Transplantation and Single-Unit Umbilical Cord Blood Transplantation as Alternative Donors in Adults with Acute Leukemia. (2020)
  • Author(s): Miyao K, Terakura S, Kimura F, Konuma T, Miyamura K, Yanada M, Kako S, Morhishima S, Uchida N, Toya T, Ozawa Y, Fukuda T, Tanaka M, Sawa M, Takada S, Yoshida S, Kimura T, Ichinohe T, Atsuta Y, Kanda J
  • Journal Title: Biol Blood Marrow Transplant. Volume: 26(11) Issue: 11 Pages: 2105-2114
  • DOI: 10.1016/j.bbmt.2020.08.001
  • Peer Reviewed
• [Journal Article] Artificial T cell adaptor molecule-transduced TCR-T cells demonstrated improved proliferation only when transduced in a higher intensity. (2020)
  • Author(s): Sakai T, Terakura S, Miyao K, Okuno S, Adachi Y, Umemura K, Julamanee J, Watanabe K, Hamana H, Kishi H, Leitner J, Steinberger P, Nishida T, Murata M, Kiyoi H.
  • Journal Title: Mol. Ther. Oncolytics Volume: 18 Pages: 613-622
  • DOI: 10.1016/j.omto.2020.08.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Randomised controlled trial of conditioning regimen for cord blood transplantation for adult myeloid malignancies comparing high-dose cytarabine/cyclophosphamide/total body irradiation with versus without G-CSF priming: G-CONCORD study protocol. (2020)
  • Author(s): Terakura S, Konuma T, Tanaka M, Ozawa Y, Onizuka M, Nanno S, Onishi Y, Aotsuka N, Kondo T, Kawakita T, Kato J, Kobayashi T, Nishida T, Yamaguchi T, Kuwatsuka Y, Takahashi S.
  • Journal Title: BMJ Open. Volume: 10(12) Issue: 12 Pages: e040467-e040467
  • DOI: 10.1136/bmjopen-2020-040467
  • Peer Reviewed / Open Access
• [Journal Article] Effect of cytomegalovirus reactivation with or without acute graft-versus-host disease on the risk of nonrelapse mortality (2020)
  • Author(s): Akahoshi Y, Kimura SI, Inamoto Y, Seo S, Muranushi H, Shimizu H, Ozawa Y, Tanaka M, Uchida N, Kanda Y, Katayama Y, Shiratori S, Ota S, Matsuoka KI, Onizuka M, Fukuda T, Atsuta Y, Murata M, Terakura S, Nakasone H.
  • Journal Title: Clin Infect Dis Volume: - Issue: 3 Pages: e620-e628
  • DOI: 10.1093/cid/ciaa1871
  • Peer Reviewed / Open Access
• [Journal Article] Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation. (2020)
  • Author(s): Kamoshita S, Murata M, Koyama D, Julamanee J, Okuno S, Takagi E, Miyao K, Goto T, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.
  • Journal Title: International Journal of Hematology Volume: 111 Issue: 1 Pages: 112-119
  • DOI: 10.1007/s12185-019-02739-2
  • NAID: 120006848998
  • Peer Reviewed
• [Journal Article] Prospective Phase 2 Study of Umbilical Cord Blood Transplantation in Adult Acute Leukemia and Myelodysplastic Syndrome (2020)
  • Author(s): Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Kohno A, Onishi Y, Fukuhara N, Kasai M, Fujii N, Yokoyama H, Iida H, Kanemura N, Fujieda A, Ago H, Tsutsumi Y, Nakamura F, Yago K, Moriuchi Y, Ota S, Ohashi H, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 26 Issue: 1 Pages: 139-144
  • DOI: 10.1016/j.bbmt.2019.09.021
  • Peer Reviewed
• [Journal Article] Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning (2020)
  • Author(s): Terakura S, Onizuka M, Fukumoto M, Kuwatsuka Y, Kohno A, Ozawa Y, Miyamura K, Inagaki Y, Sawa M, Atsuta Y, Suzuki R, Naoe T, Morishita Y, Murata M
  • Journal Title: Int J Hematol Volume: 111 Issue: 1 Pages: 84-92
  • DOI: 10.1007/s12185-019-02741-8
  • Peer Reviewed
• [Journal Article] Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues. (2019)
  • Author(s): Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H
  • Journal Title: Biol Blood Marrow Transplant Volume: 25 Issue: 3 Pages: 417-423
  • DOI: 10.1016/j.bbmt.2018.10.012
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors. (2019)
  • Author(s): Wakamatsu M, Terakura S, Ohashi K, Fukuda T, Ozawa Y, Kanamori H, Sawa M, Uchida N, Ota S, Matsushita A, Kanda Y, Nakamae H, Ichinohe T, Kato K, Murata M, Atsuta Y, Teshima T.
  • Journal Title: Blood Adv Volume: 3 Issue: 2 Pages: 105-115
  • DOI: 10.1182/bloodadvances.2018025643
  • Peer Reviewed / Open Access
• [Journal Article] Introduction of genetically modified CD3ζ improves proliferation and persistence of antigen-specific CTLs. (2018)
  • Author(s): Miyao K, Terakura S, Okuno S, Julamanee J, Watanabe K, Hamana H, Kishi H, Sakemura R, Koyama D, Goto T, Nishida T, Murata M, Kiyoi H.
  • Journal Title: Cancer Immunol Res Volume: 6 Issue: 6 Pages: 733-744
  • DOI: 10.1158/2326-6066.cir-17-0538
  • Peer Reviewed
• [Journal Article] Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol (2018)
  • Author(s): Goto T, Murata M, Terakura S, Nishida T, Adachi Y, Ushijima Y, Shimada K, Ishikawa Y, Hayakawa F, Nishio N, Nishiwaki S, Hirakawa A, Kato K, Takahashi Y, Kiyoi H
  • Journal Title: Medicine Volume: 97 Issue: 17 Pages: e0449-e0449
  • DOI: 10.1097/md.0000000000010449
  • Peer Reviewed / Open Access
• [Journal Article] Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia. (2018)
  • Author(s): Hattori H, Ishikawa Y, Kawashima N, Akashi A, Yamaguchi Y, Harada Y, Hirano D, Adachi Y, Miyao K, Ushijima Y, Terakura S, Nishida T, Matsushita T, Kiyoi H
  • Journal Title: PLoS One Volume: 13 Issue: 10 Pages: e0204850-e0204850
  • DOI: 10.1371/journal.pone.0204850
  • Peer Reviewed / Open Access
• [Presentation] 遺伝子改変CD3z人工アダプター分子のTCRに対する至適遺伝子導入比率の検討. (2020)
  • Author(s): 堺 寿保, 寺倉精太郎, 奥野真吾, 宮尾康太郎, 浜名 洋, 岸 裕幸, 西田徹也, 村田 誠, 清井 仁.
  • Organizer: 第12回日本血液疾患免疫療法学会学術集会
• [Presentation] 遺伝子改変CD3z人工アダプター分子を用いた新規機能増幅型TCRベクターの開発 (2020)
  • Author(s): 堺寿保、寺倉精太郎、奥野真吾、宮尾康太郎、浜名洋、岸裕幸、西田徹也、村田誠、清井仁
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] CD37CAR-T細胞の開発における抗原認識の最適化 (2020)
  • Author(s): 奥野真吾、安達慶高、寺倉精太郎、Jakrawadee Julamanee, 堺寿保、西田徹也、村田誠、清井仁
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] 成人急性骨髄性白血病に対する臍帯血移植後のGVHD予防におけるメソトレキサート投与量の影響. (2020)
  • Author(s): 寺倉 精太郎、鍬塚 八千代、杉田 純一、高橋 聡、小澤 幸泰、尾関 和貴、吉岡 聡、中前 博久、河北 敏郎、澤 正史、森重 聡、名島 悠峰、勝岡 優奈、堺田 惠美子、香西 康司、木村 貴文、一戸 辰夫、福田 隆浩、熱田 由子、村田 誠、豊嶋 崇徳.
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] 成人難治性血液悪性腫瘍に対する非血縁者間臍帯血移植の有効性に関する研究（臨床第II相試験） (2020)
  • Author(s): 澤 正史, 寺倉精太郎, 西田徹也, 加藤智則, 宮尾康太郎, 小澤幸泰, 河野彰夫, 大西 康, 福原規子, 笠井雅信, 藤井伸治, 横山寿行, 飯田浩充, 兼村信宏, 藤枝敦史, 吾郷浩厚, 堤 豊, 中村文彦, 野吾和宏, 森内幸美, 太田秀一, 大橋春彦, 柳澤昌実, 鈴木律朗, 鍬塚八千代, 熱田由子, 宮村耕一, 村田 誠.
  • Organizer: 第42回日本造血細胞移植学会総会
• [Presentation] Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells. (2019)
  • Author(s): Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.
  • Organizer: The 61th Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood. (2019)
  • Author(s): Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Goto T, Kohno A, Ozeki K, Onishi Y, Fukuhara N, Fujii N, Yokoyama H, Kasai M, Iida H, Kanemura N, Endo T, Ago H, Onizuka M, Iyama S, Nawa Y, Nakamae M, Nagata Y, Kurahashi S, Tomiya Y, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M.
  • Organizer: The 61th Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] CD37抗原に対する新規キメラ遺伝子導入T細胞療法の開発 (2019)
  • Author(s): 奥野真吾, 寺倉精太郎, Jakrawadee Julamanee, 堺 寿保, 今橋伸彦, 西田徹也, 村田 誠, 清井 仁.
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] The Composite CD79A/CD40 Costimulatory Endodomain Enhances CD19 Chimeric Antigen Receptoor T-Cell Proliferation and Survival (2019)
  • Author(s): Jakrawadee Julamanee、寺倉精太郎、宮尾康太郎、奥野真吾、鴨下園子、高木えり奈、堺寿保、岡崎翔一郎、梅村晃史、小山大輔、後藤辰徳、今橋伸彦、西田徹也、村田誠、清井仁
  • Organizer: The 10th JSH International Symposium 2019
• [Presentation] Impacts of ATG for conditioning in patients with acute leukemia undergoing allogeneic HSCT across different donors (2019)
  • Author(s): 若松学, 寺倉精太郎, 大橋一輝, 福田隆浩, 小澤幸泰, 金森平和, 澤正史, 内田直之, 太田秀一, 松下明子, 神田善伸, 中前博久, 一戸辰夫, 加藤剛二, 村田誠, 熱田由子, 豊嶋崇徳
  • Organizer: 日本造血細胞移植学会
• [Presentation] 同種移植におけるCAR-T細胞療法 (2019)
  • Author(s): 寺倉精太郎
  • Organizer: 日本造血細胞移植学会
  • Invited
• [Presentation] The CD79A/CD40 composite costimulatory domain enhances CD19 CAR-T cell proliferation and persistence (2018)
  • Author(s): Jakrawadee Julamanee, Seitaro Terakura, Kotaro Miyao, Shingo Okuno, Sonoko Kamoshita, Erina Takagi, Toshiyasu Sakai, Shoichiro Okazaki, Daisuke Koyama, Tatsunori Goto, Tetsuya Nishida, Makoto Murata, Hitoshi Kiyoi
  • Organizer: 日本血液学会学術集会
• [Presentation] 4.新規CD79Ａ/CD40共刺激ドメインはCD19CAR-T細胞の刺激後増殖と生存を向上させる (2018)
  • Author(s): Jakrawadee Julamanee, Seitaro Terakura, Kotaro Miyao, Shingo Okuno, Sonoko Kamoshita, Erina Takagi, Toshiyasu Sakai, Shoichiro Okazaki, Daisuke Koyama, Tatsunori Goto, Tetsuya Nishida, Makoto Murata and Hitoshi Kiyoi
  • Organizer: 血液疾患免疫療法学会学術集会
• [Patent(Industrial Property Rights)] キメラ抗原受容体 (2020)
  • Inventor(s): Seitaro Terakura
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
  • Overseas
• [Patent(Industrial Property Rights)] CD37特異的キメラ抗原レセプター (2019)
  • Inventor(s): 寺倉精太郎、清井仁、奥野真吾
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] ＣＤ３７特異的キメラ抗原レセプター (2018)
  • Inventor(s): 寺倉精太郎、清井仁、奥野真吾
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-122519
  • Filing Date: 2018