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Enhancement of Intracellular Signaling in T Cell Receptor-transduced T Cells

Research Project

Project/Area Number 18K08351
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54010:Hematology and medical oncology-related
Research InstitutionNagoya University

Principal Investigator

Terakura Seitaro  名古屋大学, 医学部附属病院, 講師 (40625141)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords遺伝子導入T細胞療法 / アダプター分子 / Tリンパ球 / TCR遺伝子導入 / T細胞養子免疫療法 / 新規アダプター分子 / 遺伝子導入T細胞 / T細胞内シグナル / 遺伝子改変
Outline of Final Research Achievements

In this study, we attempted to develop a novel vector that enables gene transfer of TCR and adapter molecule (ATAM) into T cells by a single gene transfer. One virus vector method (1vv method) using all-in-one vector and two virus vector (2vv) method using two vectors used in the previous study showed that the expression of ATAM was about 3 times higher in 2vv method. The expression of ATAM was about 3-fold higher in the 2vv method. Comparison of the function of the TCR-T cells generated by the 2vv method showed that the cells generated by the 2vv method proliferated significantly better after antigen stimulation, and the intracellular signals after stimulation showed that the signals of phosphorylated Erk and p38 were significantly enhanced in the TCR-T cells generated by the 2vv method. The results showed that it is necessary to transfer three times more ATAM than TCR.

Academic Significance and Societal Importance of the Research Achievements

T細胞レセプター遺伝子と新規に開発したアダプター分子を1回の遺伝子導入によりT細胞内に遺伝子導入可能とする新規ベクターの開発を試みた。ひとつのベクターで遺伝し導入する1 virus vector法(1vv法)と二つのウイルスベクターを用いる方法 (2 virus vector法, 2vv法)を比較したところ、ウェスタンブロット法でも、フローサイト メトリー法でも2vv法でアダプター分子の発現が約3倍程度高く、2vv法で作成したTCR-Tの方が有意に抗原刺激後の増殖が有利であった。TCRよりも3倍以上多くのアダプター分子を遺伝子導入する必要があることが示された。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (39 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 10 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] Medical University of Vienna(オーストリア)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Comparison of immunosuppressant regimens in salvage cord blood transplantation for graft failure after allogeneic hematopoietic stem cell transplantation2021

    • Author(s)
      Harada K, Fuji S, Seo S, Uchida N, Kawakita T, Yano S, Ozawa Y, Yoshioka S, Onishi Y, Noguchi Y, Onizuka M, Matsuhashi Y, Kimura T, Ichinohe T, Atsuta Y, Terakura S, Nakasone H.
    • Journal Title

      Bone Marrow Transplant

      Volume: 56(2) Issue: 2 Pages: 400-410

    • DOI

      10.1038/s41409-020-00999-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation.2021

    • Author(s)
      Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Suzuki S, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.
    • Journal Title

      Stem Cells Transl Med.

      Volume: 10(4) Issue: 4 Pages: 542-553

    • DOI

      10.1002/sctm.20-0381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin.2021

    • Author(s)
      Nishida T, Kobayashi T, Sawa M, Masuda S, Shibasaki Y, Goto T, Fukuhara N, Fujii N, Ikegame K, Sugita J, Ikeda T, Kuwatsuka Y, Suzuki R, Najima Y, Doki N, Kato T, Inagaki Y, Utsu Y, Aotsuka N, Masuko M, Terakura S, Onishi Y, Maeda Y, Okada M, Teshima T, Murata M.
    • Journal Title

      Annals of Hematology

      Volume: 100 Issue: 3 Pages: 743-752

    • DOI

      10.1007/s00277-020-04365-z

    • NAID

      120007147363

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia2021

    • Author(s)
      Terakura S, Kuwatsuka Y, Sugita J, Takahashi S, Ozawa Y, Ozeki K, Yoshioka S, Nakamae H, Kawakita T, Sawa M, Morishige S, Najima Y, Katsuoka Y, Sakaida E, Kouzai Y, Kimura T, Ichinohe T, Fukuda T, Atsuta Y, Murata M, Teshima T.
    • Journal Title

      Int J Hematol

      Volume: - Issue: 6 Pages: 840-850

    • DOI

      10.1007/s12185-021-03097-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single Cord Blood Transplantation Versus Unmanipulated Haploidentical Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission.2021

    • Author(s)
      Konuma T, Kanda J, Yamasaki S, Harada K, Shimomura Y, Terakura S, Mizuno S, Uchida N, Tanaka M, Doki N, Ozawa Y, Nakamae H, Sawa M, Matsuoka KI, Morishige S, Maruyama Y, Ikegame K, Kimura T, Kanda Y, Ichinohe T, Atsuta Y, Yanada M.
    • Journal Title

      Transplant Cell Ther.

      Volume: 27(4) Issue: 4 Pages: 334.e1-334.e11

    • DOI

      10.1016/j.jtct.2021.01.023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Transplantation Outcomes after Foscarnet and Ganciclovir Administration as First-Line Anti-Cytomegalovirus Preemptive Therapy2021

    • Author(s)
      Miyao K, Terakura S, Ozawa Y, Sawa M, Kohno A, Kasahara S, Iida H, Ino K, Kusumoto S, Kasai M, Takami A, Kurahashi S, Kajiguchi T, Morishita T, Nishida T, Murata M; Nagoya Blood and Marrow Transplantation Group.
    • Journal Title

      Transplant Cell Ther

      Volume: 27(4) Issue: 4 Pages: 342.e1-342.e10

    • DOI

      10.1016/j.jtct.2020.12.012

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective evaluation of alternative donor from unrelated donor and cord blood in adult acute leukemia and myelodysplastic syndrome2020

    • Author(s)
      Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Goto T, Kohno A, Ozeki K, Onishi Y, Fukuhara N, Fujii N, Yokoyama H, Kasai M, Iida H, Kanemura N, Endo T, Ago H, Onizuka M, Iyama S, Nawa Y, Nakamae M, Nagata Y, Kurahashi S, Tomiya Y, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M
    • Journal Title

      Bone Marrow Transplantation

      Volume: -- Issue: 7 Pages: 1399-1409

    • DOI

      10.1038/s41409-020-0859-8

    • NAID

      120006891238

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies2020

    • Author(s)
      Imahashi Nobuhiko、Terakura Seitaro、Kondo Eisei、Kako Shinichi、Uchida Naoyuki、Kobayashi Hikaru、Inamoto Yoshihiro、Sakai Hitoshi、Tanaka Masatsugu、Ishikawa Jun、Kozai Yasuji、Matsuoka Ken-ichi、Kimura Takafumi、Fukuda Takahiro、Atsuta Yoshiko、Kanda Junya
    • Journal Title

      Bone Marrow Transplantation

      Volume: 55 Issue: 11 Pages: 2098

    • DOI

      10.1038/s41409-020-0905-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Staurosporine and venetoclax induce the caspase- dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.2020

    • Author(s)
      Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
    • Journal Title

      Biomed Pharmacother.

      Volume: 128 Pages: 110330-110330

    • DOI

      10.1016/j.biopha.2020.110330

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and efficacy of anti-programmed cell death-1 monoclonal antibodies before and after allogeneic hematopoietic cell transplantation for relapsed or refractory Hodgkin lymphoma: a multicenter retrospective study2020

    • Author(s)
      Ito Ayumu、(15名)、Takemura Tomonari、Terakura Seitaro、Iida Hiroatsu、Nakamae Mika、Higuchi Kohei、Tamura Shinobu、Yoshioka Satoshi、Togitani Kazuto、Kawano Noriaki、Suzuki Ritsuro、Suzumiya Junji、Izutsu Koji、Teshima Takanori、Fukuda Takahiro
    • Journal Title

      International Journal of Hematology

      Volume: 112 Issue: 5 Pages: 674-689

    • DOI

      10.1007/s12185-020-02960-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Updated Comparison of 7/8 HLA Allele-Matched Unrelated Bone Marrow Transplantation and Single-Unit Umbilical Cord Blood Transplantation as Alternative Donors in Adults with Acute Leukemia.2020

    • Author(s)
      Miyao K, Terakura S, Kimura F, Konuma T, Miyamura K, Yanada M, Kako S, Morhishima S, Uchida N, Toya T, Ozawa Y, Fukuda T, Tanaka M, Sawa M, Takada S, Yoshida S, Kimura T, Ichinohe T, Atsuta Y, Kanda J
    • Journal Title

      Biol Blood Marrow Transplant.

      Volume: 26(11) Issue: 11 Pages: 2105-2114

    • DOI

      10.1016/j.bbmt.2020.08.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial T cell adaptor molecule-transduced TCR-T cells demonstrated improved proliferation only when transduced in a higher intensity.2020

    • Author(s)
      Sakai T, Terakura S, Miyao K, Okuno S, Adachi Y, Umemura K, Julamanee J, Watanabe K, Hamana H, Kishi H, Leitner J, Steinberger P, Nishida T, Murata M, Kiyoi H.
    • Journal Title

      Mol. Ther. Oncolytics

      Volume: 18 Pages: 613-622

    • DOI

      10.1016/j.omto.2020.08.014

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Randomised controlled trial of conditioning regimen for cord blood transplantation for adult myeloid malignancies comparing high-dose cytarabine/cyclophosphamide/total body irradiation with versus without G-CSF priming: G-CONCORD study protocol.2020

    • Author(s)
      Terakura S, Konuma T, Tanaka M, Ozawa Y, Onizuka M, Nanno S, Onishi Y, Aotsuka N, Kondo T, Kawakita T, Kato J, Kobayashi T, Nishida T, Yamaguchi T, Kuwatsuka Y, Takahashi S.
    • Journal Title

      BMJ Open.

      Volume: 10(12) Issue: 12 Pages: e040467-e040467

    • DOI

      10.1136/bmjopen-2020-040467

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of cytomegalovirus reactivation with or without acute graft-versus-host disease on the risk of nonrelapse mortality2020

    • Author(s)
      Akahoshi Y, Kimura SI, Inamoto Y, Seo S, Muranushi H, Shimizu H, Ozawa Y, Tanaka M, Uchida N, Kanda Y, Katayama Y, Shiratori S, Ota S, Matsuoka KI, Onizuka M, Fukuda T, Atsuta Y, Murata M, Terakura S, Nakasone H.
    • Journal Title

      Clin Infect Dis

      Volume: - Issue: 3 Pages: e620-e628

    • DOI

      10.1093/cid/ciaa1871

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation.2020

    • Author(s)
      Kamoshita S, Murata M, Koyama D, Julamanee J, Okuno S, Takagi E, Miyao K, Goto T, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.
    • Journal Title

      International Journal of Hematology

      Volume: 111 Issue: 1 Pages: 112-119

    • DOI

      10.1007/s12185-019-02739-2

    • NAID

      120006848998

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective Phase 2 Study of Umbilical Cord Blood Transplantation in Adult Acute Leukemia and Myelodysplastic Syndrome2020

    • Author(s)
      Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Kohno A, Onishi Y, Fukuhara N, Kasai M, Fujii N, Yokoyama H, Iida H, Kanemura N, Fujieda A, Ago H, Tsutsumi Y, Nakamura F, Yago K, Moriuchi Y, Ota S, Ohashi H, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M
    • Journal Title

      Biology of Blood and Marrow Transplantation

      Volume: 26 Issue: 1 Pages: 139-144

    • DOI

      10.1016/j.bbmt.2019.09.021

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of glutathione S-transferase and cytochrome P450 gene polymorphism in recipients of dose-adjusted busulfan-cyclophosphamide conditioning2020

    • Author(s)
      Terakura S, Onizuka M, Fukumoto M, Kuwatsuka Y, Kohno A, Ozawa Y, Miyamura K, Inagaki Y, Sawa M, Atsuta Y, Suzuki R, Naoe T, Morishita Y, Murata M
    • Journal Title

      Int J Hematol

      Volume: 111 Issue: 1 Pages: 84-92

    • DOI

      10.1007/s12185-019-02741-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues.2019

    • Author(s)
      Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 25 Issue: 3 Pages: 417-423

    • DOI

      10.1016/j.bbmt.2018.10.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors.2019

    • Author(s)
      Wakamatsu M, Terakura S, Ohashi K, Fukuda T, Ozawa Y, Kanamori H, Sawa M, Uchida N, Ota S, Matsushita A, Kanda Y, Nakamae H, Ichinohe T, Kato K, Murata M, Atsuta Y, Teshima T.
    • Journal Title

      Blood Adv

      Volume: 3 Issue: 2 Pages: 105-115

    • DOI

      10.1182/bloodadvances.2018025643

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Introduction of genetically modified CD3ζ improves proliferation and persistence of antigen-specific CTLs.2018

    • Author(s)
      Miyao K, Terakura S, Okuno S, Julamanee J, Watanabe K, Hamana H, Kishi H, Sakemura R, Koyama D, Goto T, Nishida T, Murata M, Kiyoi H.
    • Journal Title

      Cancer Immunol Res

      Volume: 6 Issue: 6 Pages: 733-744

    • DOI

      10.1158/2326-6066.cir-17-0538

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol2018

    • Author(s)
      Goto T, Murata M, Terakura S, Nishida T, Adachi Y, Ushijima Y, Shimada K, Ishikawa Y, Hayakawa F, Nishio N, Nishiwaki S, Hirakawa A, Kato K, Takahashi Y, Kiyoi H
    • Journal Title

      Medicine

      Volume: 97 Issue: 17 Pages: e0449-e0449

    • DOI

      10.1097/md.0000000000010449

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia.2018

    • Author(s)
      Hattori H, Ishikawa Y, Kawashima N, Akashi A, Yamaguchi Y, Harada Y, Hirano D, Adachi Y, Miyao K, Ushijima Y, Terakura S, Nishida T, Matsushita T, Kiyoi H
    • Journal Title

      PLoS One

      Volume: 13 Issue: 10 Pages: e0204850-e0204850

    • DOI

      10.1371/journal.pone.0204850

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 遺伝子改変CD3z人工アダプター分子のTCRに対する至適遺伝子導入比率の検討.2020

    • Author(s)
      堺 寿保, 寺倉精太郎, 奥野真吾, 宮尾康太郎, 浜名 洋, 岸 裕幸, 西田徹也, 村田 誠, 清井 仁.
    • Organizer
      第12回日本血液疾患免疫療法学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子改変CD3z人工アダプター分子を用いた新規機能増幅型TCRベクターの開発2020

    • Author(s)
      堺寿保、寺倉精太郎、奥野真吾、宮尾康太郎、浜名洋、岸裕幸、西田徹也、村田誠、清井仁
    • Organizer
      第82回日本血液学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] CD37CAR-T細胞の開発における抗原認識の最適化2020

    • Author(s)
      奥野真吾、安達慶高、寺倉精太郎、Jakrawadee Julamanee, 堺寿保、西田徹也、村田誠、清井仁
    • Organizer
      第82回日本血液学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 成人急性骨髄性白血病に対する臍帯血移植後のGVHD予防におけるメソトレキサート投与量の影響.2020

    • Author(s)
      寺倉 精太郎、鍬塚 八千代、杉田 純一、高橋 聡、小澤 幸泰、尾関 和貴、吉岡 聡、中前 博久、河北 敏郎、澤 正史、森重 聡、名島 悠峰、勝岡 優奈、堺田 惠美子、香西 康司、木村 貴文、一戸 辰夫、福田 隆浩、熱田 由子、村田 誠、豊嶋 崇徳.
    • Organizer
      第43回日本造血細胞移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 成人難治性血液悪性腫瘍に対する非血縁者間臍帯血移植の有効性に関する研究(臨床第II相試験)2020

    • Author(s)
      澤 正史, 寺倉精太郎, 西田徹也, 加藤智則, 宮尾康太郎, 小澤幸泰, 河野彰夫, 大西 康, 福原規子, 笠井雅信, 藤井伸治, 横山寿行, 飯田浩充, 兼村信宏, 藤枝敦史, 吾郷浩厚, 堤 豊, 中村文彦, 野吾和宏, 森内幸美, 太田秀一, 大橋春彦, 柳澤昌実, 鈴木律朗, 鍬塚八千代, 熱田由子, 宮村耕一, 村田 誠.
    • Organizer
      第42回日本造血細胞移植学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells.2019

    • Author(s)
      Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.
    • Organizer
      The 61th Annual Meeting of the American Society of Hematology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood.2019

    • Author(s)
      Terakura S, Nishida T, Sawa M, Kato T, Miyao K, Ozawa Y, Goto T, Kohno A, Ozeki K, Onishi Y, Fukuhara N, Fujii N, Yokoyama H, Kasai M, Iida H, Kanemura N, Endo T, Ago H, Onizuka M, Iyama S, Nawa Y, Nakamae M, Nagata Y, Kurahashi S, Tomiya Y, Yanagisawa A, Suzuki R, Kuwatsuka Y, Atsuta Y, Miyamura K, Murata M.
    • Organizer
      The 61th Annual Meeting of the American Society of Hematology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] CD37抗原に対する新規キメラ遺伝子導入T細胞療法の開発2019

    • Author(s)
      奥野真吾, 寺倉精太郎, Jakrawadee Julamanee, 堺 寿保, 今橋伸彦, 西田徹也, 村田 誠, 清井 仁.
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] The Composite CD79A/CD40 Costimulatory Endodomain Enhances CD19 Chimeric Antigen Receptoor T-Cell Proliferation and Survival2019

    • Author(s)
      Jakrawadee Julamanee、寺倉精太郎、宮尾康太郎、奥野真吾、鴨下園子、高木えり奈、堺寿保、岡崎翔一郎、梅村晃史、小山大輔、後藤辰徳、今橋伸彦、西田徹也、村田誠、清井仁
    • Organizer
      The 10th JSH International Symposium 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Impacts of ATG for conditioning in patients with acute leukemia undergoing allogeneic HSCT across different donors2019

    • Author(s)
      若松学, 寺倉精太郎, 大橋一輝, 福田隆浩, 小澤幸泰, 金森平和, 澤正史, 内田直之, 太田秀一, 松下明子, 神田善伸, 中前博久, 一戸辰夫, 加藤剛二, 村田誠, 熱田由子, 豊嶋崇徳
    • Organizer
      日本造血細胞移植学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 同種移植におけるCAR-T細胞療法2019

    • Author(s)
      寺倉精太郎
    • Organizer
      日本造血細胞移植学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] The CD79A/CD40 composite costimulatory domain enhances CD19 CAR-T cell proliferation and persistence2018

    • Author(s)
      Jakrawadee Julamanee, Seitaro Terakura, Kotaro Miyao, Shingo Okuno, Sonoko Kamoshita, Erina Takagi, Toshiyasu Sakai, Shoichiro Okazaki, Daisuke Koyama, Tatsunori Goto, Tetsuya Nishida, Makoto Murata, Hitoshi Kiyoi
    • Organizer
      日本血液学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 4.新規CD79A/CD40共刺激ドメインはCD19CAR-T細胞の刺激後増殖と生存を向上させる2018

    • Author(s)
      Jakrawadee Julamanee, Seitaro Terakura, Kotaro Miyao, Shingo Okuno, Sonoko Kamoshita, Erina Takagi, Toshiyasu Sakai, Shoichiro Okazaki, Daisuke Koyama, Tatsunori Goto, Tetsuya Nishida, Makoto Murata and Hitoshi Kiyoi
    • Organizer
      血液疾患免疫療法学会学術集会
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] キメラ抗原受容体2020

    • Inventor(s)
      Seitaro Terakura
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] CD37特異的キメラ抗原レセプター2019

    • Inventor(s)
      寺倉精太郎、清井仁、奥野真吾
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] CD37特異的キメラ抗原レセプター2018

    • Inventor(s)
      寺倉精太郎、清井仁、奥野真吾
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-122519
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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