• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Preclinical research for the clinical application of T-cell receptor gene therapy targeting tax for adult T-cell leukemia/lymphoma

Research Project

Project/Area Number 18K08369
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54010:Hematology and medical oncology-related
Research InstitutionJichi Medical University

Principal Investigator

Kanda Yoshinobu  自治医科大学, 医学部, 教授 (30334379)

Co-Investigator(Kenkyū-buntansha) 仲宗根 秀樹  自治医科大学, 医学部, 講師 (50757903)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords免疫細胞療法 / 成人T細胞性白血病 / 遺伝子治療 / 成人T 細胞白血病・リンパ腫 / Tax / 腫瘍免疫
Outline of Final Research Achievements

Adult T-cell leukemia/lymphoma is a hematological malignancy caused by Human T-cell Leukemia Virus Type 1 (HTLV-I). We have previously transduced TCR-alpha/beta genes, cloned from a tax-specific CTL clone, into peripheral blood mononuclear cells (PBMCs) of healthy volunteers, and those cells showed strong cytotoxic activity against HTLV-I infected cells. In this study, we identified an ideal condition to transduce those genes into PBMCs from patients with ATL, because we are planning to use autologous gene-modified cells in clinical settings. In addition, we have established a blood test tool to quantitate Tax mRNA, and currently developing it as a companion diagnostic test to evaluate the sensitivity to Tax-specific immunotherapy.

Academic Significance and Societal Importance of the Research Achievements

成人T 細胞白血病・リンパ腫(ATL)は極めて難治性の造血器腫瘍であり、同種造血幹細胞移植が唯一の根治的治療法であるが、その予後も決して優れたものではなく、また、同種造血幹細胞移植を受けることができる患者も限られている。そのため、新しい治療法の開発が熱望されている。本研究のTax特異的T細胞受容体遺伝子導入免疫細胞療法は、既存の治療法とは全く異なり機序で抗腫瘍効果をもたらすものであり、本研究成果によって、今後、この治療法を診療現場に届けための医師主導治験につなげることができる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results)

  • [Journal Article] Development of a Unique T Cell Receptor Gene-Transferred Tax-Redirected T Cell Immunotherapy for Adult T Cell Leukemia2020

    • Author(s)
      Kawamura Koji、Tanaka Yukie、Nakasone Hideki、Ishihara Yuko、Kako Shinichi、Kobayashi Seiichiro、Tanaka Yuetsu、Ohmori Tsukasa、Uchimaru Kaoru、Okamoto Sachiko、Mineno Junichi、Shiku Hiroshi、Nishimura Satoshi、Kanda Yoshinobu
    • Journal Title

      Biology of Blood and Marrow Transplantation

      Volume: 26 Issue: 8 Pages: 1377-1385

    • DOI

      10.1016/j.bbmt.2020.04.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alloreactive T Cells Display a Distinct Chemokine Profile in Response to Conditioning in Xenogeneic GVHD Models2019

    • Author(s)
      Kawasaki Yasufumi、Sato Kazuya、Kanda Yoshinobu et al.
    • Journal Title

      Transplantation

      Volume: 103 Issue: 9 Pages: 1834-1843

    • DOI

      10.1097/tp.0000000000002756

    • Related Report
      2019 Research-status Report
  • [Journal Article] Increased Mac-2 binding protein glycan isomer in patients at risk for late nonrelapse mortality after HSCT2019

    • Author(s)
      Akahoshi Yu、Nakasone Hideki、Kawamura Koji、Kusuda Machiko、Kawamura Shunto、Takeshita Junko、Yoshino Nozomu、Misaki Yukiko、Yoshimura Kazuki、Gomyo Ayumi、Tanihara Aki、Tamaki Masaharu、Kimura Shun-ichi、Kako Shinichi、Kanda Yoshinobu
    • Journal Title

      Blood Advances

      Volume: 3 Issue: 21 Pages: 3287-3296

    • DOI

      10.1182/bloodadvances.2019000629

    • Related Report
      2019 Research-status Report
  • [Journal Article] Alloreactive T-cells display a distinct chemokine profile in response to conditioning in xenogeneic GVHD models.2019

    • Author(s)
      Yasufumi Kawasaki, Kazuya Sato, Yoshinobu Kanda, et al.
    • Journal Title

      Transplantation

      Volume: -

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Analysis of the Activation and Proliferation Kinetics and Effector Functions of Human Lymphocytes, and Antigen Presentation Capacity of Antigen-Presenting Cells in Xenogeneic Graft-Versus-Host Disease2018

    • Author(s)
      Kawasaki Yasufumi、Sato Kazuya、Hayakawa Hiroko、Takayama Norihito、Nakano Hirofumi、Ito Ryoji、Mashima Kiyomi、Oh Iekuni、Minakata Daisuke、Yamasaki Ryoko、Morita Kaoru、Ashizawa Masahiro、Yamamoto Chihiro、Hatano Kaoru、Fujiwara Shin-ichiro、Ohmine Ken、Muroi Kazuo、Kanda Yoshinobu
    • Journal Title

      Biology of Blood and Marrow Transplantation

      Volume: 印刷中 Issue: 8 Pages: 1563-1574

    • DOI

      10.1016/j.bbmt.2018.04.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi