Elucidation of the mechanism of joint destruction in rheumatoid arthritis: approach using high-resolution CT
| Project/Area Number |
18K08390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
Tamai Mami 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380862)
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| Co-Investigator(Kenkyū-buntansha) |
千葉 恒 長崎大学, 医歯薬学総合研究科(医学系), 助教 (00457574)
川尻 真也 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20457576)
有馬 和彦 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30423635)
上谷 雅孝 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40176582)
大山 要 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (50437860)
岩本 直樹 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80437897)
川上 純 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90325639)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 関節リウマチ / 関節破壊 / 高解像度CT（HRpQCT） / 骨関節破壊 / HR-pQCT / MRI / 関節超音波 / 高解像度CT / 関節裂隙 / 関節傷害 / 関節エコー |
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| Outline of Final Research Achievements |
Joints were evaluated using high-resolution peripheral quantitative CT (HR-pQCT) in active rheumatoid arthritis with a high rate of autoantibody positivity, MRI bone marrow edema, and active synovitis on ultrasound. After 1 year, 80% remission was achieved and less radiographic progression was observed. On the other hand, HR-pQCT showed changes, with five new bone erosions, but half of the existing erosions were reduced in size, with a decrease in volume and an increase in bone density. Joint space increased in volume and width. These findings differed between drugs, with 50% of methotrexate-treated patients and 30% of biologic-treated patients showing a decrease in both volume and width.HR-pQCT was able to detect bone and joint changes earlier than radiographs, MRI, or US.
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| Academic Significance and Societal Importance of the Research Achievements |
高い解像度を有するHR-pQCTを用いて、関節リウマチ患者を対象に手指関節を治療経過と共に詳細に評価した。従来の高感度画像とされる超音波やMRIの研究では得られなかった知見を今回観察することができた。すなわち、関節裂隙、骨びらん、骨微細構造（骨粗鬆）の治療による経過が少ない症例ながら明らかになった。薬剤間で所見の違いが認められ、更なる研究の推進が望まれる。今後、日常診療に有用な知見を得られる可能性が高い。
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Report
(5 results)
Research Products
(5 results)
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[Presentation] MRI in Rheumatoid Arthritis2020
Author(s)
Mami Tamai, Masataka Uetani, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
Organizer
22nd Aisa-Pacific League of Associations for Rheumatology
Related Report
Int'l Joint Research / Invited
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