Organ- and intermolecular interactions of heat stress response pathway activation that exert anti-diabetic effects

• Project/Area Number: 18K08482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Kumamoto University
• Principal Investigator: Kondo Tatsuya 熊本大学, 病院, 講師 (70398204)
• Co-Investigator(Kenkyū-buntansha): 荒木 栄一 熊本大学, 大学院生命科学研究部(医), 教授 (10253733)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 糖尿病 / 慢性炎症 / インスリン抵抗性 / 脂肪肝 / 細胞内ストレス / 熱ストレス応答経路

Outline of Final Research Achievements

Heat shock protein (HSP72) originally has a biological defense, anti-diabetic, and anti-inflammatory effect, but HSP72 expression is decreased in the pathological condition of type 2 diabetes. In this study, restoration of HSP72 expression specifically in the liver improved systemic insulin sensitivity and glucose tolerance. Of particular note, improvement of fatty liver and visceral fat size were observed, indicating that the recovery of HSP72 in the liver affected distant organ, such as adipose tissue. In order to investigate crosstalk with other organs, we constructed adipose tissue and pancreatic β-cell specific HSP72 transgenic mouse lines. We are analyzing the phenotypic changes and molecular mechanism of organ-specific HSP72 expression recovery in whole-body HSP72 knockout.

Academic Significance and Societal Importance of the Research Achievements

現在の2型糖尿病治療の中心は、薬物療法や注射療法に代表される薬理学的介入である。その選択肢は近年大きく広がってきており、血管合併症に関する有効性も示されている。一方で、生体本来の防御機構の活性化による糖尿病治療戦略は未だに確立していないが、副作用の少ない安全で負担の少ない物理的治療選択肢が増えることは、治療の裾野を広げ予防医学的観点からも期待される。今回、報告した熱ストレス応答経路の活性化に用いた温熱と微弱電流は、安全性と有効性またコストの観点から新しい糖尿病治療戦略の提唱として社会的に意義深いと考えられる。

Research Products

• [Journal Article] Distinct Differences in Lipoprotein Particle Number Evaluation between GP-HPLC and NMR: Analysis in Dyslipidemic Patients Administered a Selective PPARα Modulator, Pemafibrate (2021)
  • Author(s): Yamashita Shizuya、Okazaki Mitsuyo、Okada Takeshi、Masuda Daisaku、Yokote Koutaro、Arai Hidenori、Araki Eiichi、Ishibashi Shun
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 9 Pages: 974-996
  • DOI: 10.5551/jat.60764
  • NAID: 130008082098
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-09-01
  • Peer Reviewed / Open Access
• [Journal Article] A homogeneous assay to determine high-density lipoprotein subclass cholesterol in serum (2021)
  • Author(s): Kazumi Matsushima-Nagata, Hiroyuki Sugiuchi, Kensaku Anraku, Takako Takao, Yuki Kondo, Yoichi Ishitsuka, Mitsuru Irikura, Tetsumi Irie, Takeshi Matsumura, Eiichi Araki, Mizuki Sumida, Yuki Katayama, and Norihiko Kayahara
  • Journal Title: Analytical Biochemistry Volume: 613 Pages: 114019-114019
  • DOI: 10.1016/j.ab.2020.114019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical profiles of hyperglycemic crises: A single‐center retrospective study from Japan (2021)
  • Author(s): Nishikawa Takeshi、Kinoshita Hiroyuki、Ono Keiko、Kodama‐Hashimoto Shoko、Kobayashi Yuka、Nakamura Tomofumi、Yoshinaga Tomoaki、Ohkubo Yuma、Harada Masahiro、Toyonaga Tetsushi、Takahashi Takeshi、Araki Eiichi
  • Journal Title: Journal of Diabetes Investigation Volume: Online ahead of print. Issue: 8 Pages: 1359-1366
  • DOI: 10.1111/jdi.13475
  • Peer Reviewed / Open Access
• [Journal Article] Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) (2021)
  • Author(s): Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group.
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 9 Issue: 1 Pages: e001787-e001787
  • DOI: 10.1136/bmjdrc-2020-001787
  • Peer Reviewed / Open Access
• [Journal Article] Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021)
  • Author(s): Tateishi R、Matsumura T、Okanoue T、Shima T、Uchino K、Fujiwara N、Senokuchi T、Kon K、Sasako T、Taniai M、Kawaguchi T、Inoue H、Watada H、Kubota N、Shimano H、Kaneko S、Hashimoto E、Watanabe S、Shiota G、Ueki K、Kashiwabara K、Matsuyama Y、Tanaka H、Kasuga M、Araki E、Koike K
  • Journal Title: Journal of Gastroenterology Volume: 56 Issue: 3 Pages: 261-273
  • DOI: 10.1007/s00535-020-01754-z
  • Peer Reviewed / Open Access
• [Journal Article] Long‐term (52‐week) efficacy and safety of dapagliflozin as an adjunct to insulin therapy in Japanese patients with type 1 diabetes: Subgroup analysis of the DEPICT‐2 study (2021)
  • Author(s): Araki Eiichi、Mathieu Chantal、Shiraiwa Toshihiko、Maeda Hajime、Ikeda Hiroki、Thoren Fredrik、Arya Niki、Asano Michiko、Iqbal Nayyar
  • Journal Title: Diabetes, Obesity and Metabolism Volume: Online ahead of print. Issue: 7 Pages: 1496-1504
  • DOI: 10.1111/dom.14362
  • Peer Reviewed / Open Access
• [Journal Article] Diagnosis, Prevention, and Treatment of Cardiovascular Diseases in People With Type 2 Diabetes and Prediabetes ― A Consensus Statement Jointly From the Japanese Circulation Society and the Japan Diabetes Society ― (2020)
  • Author(s): Araki Eiichi、Tanaka Atsushi、Inagaki Nobuya、Ito Hiroshi、Ueki Kohjiro、Murohara Toyoaki、Imai Kenjiro、Sata Masataka、Sugiyama Takehiro、Ishii Hideki、Yamane Shunsuke、Kadowaki Takashi、Komuro Issei、Node Koichi、on behalf of the Directors of the JCS and JDS
  • Journal Title: Circulation Journal Volume: 85 Issue: 1 Pages: 82-125
  • DOI: 10.1253/circj.CJ-20-0865
  • NAID: 130007961200
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-12-25
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions (2020)
  • Author(s): Nishida Shuhei、Matsumura Takeshi、Senokuchi Takafumi、Murakami-Nishida Saiko、Ishii Norio、Morita Yutaro、Yagi Yoshitaka、Motoshima Hiroyuki、Kondo Tatsuya、Araki Eiichi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 524 Issue: 1 Pages: 8-15
  • DOI: 10.1016/j.bbrc.2020.01.027
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Features of Patients with Acute Aortic Dissection After an Earthquake ～Experience from The Kumamoto Earthquake 2016～ (2020)
  • Author(s): Komorita Takashi、Fujisue Koichiro、Sueta Daisuke、Sakamoto Kenji、Yamamoto Eiichiro、Hashimoto Yoichiro、Sakamoto Tomohiro、Tsunoda Ryusuke、Uesugi Hideyuki、Suzuki Ryusuke、Naito Hisaki、Hanzawa Kazuhiko、Araki Eiichi、Nakayama Hideki、Kasaoka Shunji、Hokimoto Seiji、Fukui Toshihiro、Tsujita Kenichi
  • Journal Title: American Journal of Hypertension Volume: 33 (3) Issue: 3 Pages: 261-268
  • DOI: 10.1093/ajh/hpz183
  • Peer Reviewed / Open Access
• [Journal Article] Baseline Plasma Aldosterone Level and Renin Activity Allowing Omission of Confirmatory Testing in Primary Aldosteronism (2020)
  • Author(s): Kawashima Junji、Araki Eiichi、Naruse Mitsuhide、Kurihara Isao、Takahashi Katsutoshi、Tamura Kouichi、Kobayashi Hiroki、Okamura Shintaro、Miyauchi Shozo、Yamamoto Koichi、Izawa Shoichiro、Suzuki Tomoko、Tanabe Akiyo
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 105 Issue: 5 Pages: e1990-e1998
  • DOI: 10.1210/clinem/dgaa117
  • Peer Reviewed / Open Access
• [Journal Article] New perspectives on insulin therapy (2020)
  • Author(s): Araki Eiichi、Araki Hirotaka、Senokuchi Takafumi、Motoshima Hiroyuki
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 4 Pages: 795-797
  • DOI: 10.1111/jdi.13263
  • Peer Reviewed / Open Access
• [Journal Article] Long‐term efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (the DEPICT ‐2 study): 52‐week results from a randomized controlled trial (2020)
  • Author(s): Mathieu Chantal、Rudofsky Gottfried、Phillip Moshe、Araki Eiichi、Lind Marcus、Arya Niki、Thoren Fredrik、Scheerer Markus F.、Iqbal Nayyar、Dandona Paresh
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 22 Issue: 9 Pages: 1516-1526
  • DOI: 10.1111/dom.14060
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes (2020)
  • Author(s): Kariba Yuichi、Yoshizawa Tatsuya、Sato Yoshifumi、Tsuyama Tomonori、Araki Eiichi、Yamagata Kazuya
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 530 Issue: 3 Pages: 500-507
  • DOI: 10.1016/j.bbrc.2020.05.090
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Features of Disaster-Associated Direct Deaths during Recent Inland Earthquakes in Japan (2020)
  • Author(s): Naito Hisaki、Sueta Daisuke、Nakayama Hideki、Araki Eiichi、Tanihara Hidenobu、Kasaoka Shunji、Tsujita Kenichi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 251 Issue: 3 Pages: 169-173
  • DOI: 10.1620/tjem.251.169
  • NAID: 130007871484
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Clinical Practice Guideline for Diabetes 2019 (2020)
  • Author(s): Araki Eiichi、Goto Atsushi、Kondo Tatsuya、Noda Mitsuhiko、Noto Hiroshi、Origasa Hideki、Osawa Haruhiko、Taguchi Akihiko、Tanizawa Yukio、Tobe Kazuyuki、Yoshioka Narihito
  • Journal Title: Diabetology International Volume: 11 Issue: 3 Pages: 165-223
  • DOI: 10.1007/s13340-020-00439-5
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Clinical Practice Guideline for Diabetes 2019 (2020)
  • Author(s): Araki Eiichi、Goto Atsushi、Kondo Tatsuya、Noda Mitsuhiko、Noto Hiroshi、Origasa Hideki、Osawa Haruhiko、Taguchi Akihiko、Tanizawa Yukio、Tobe Kazuyuki、Yoshioka Narihito
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 4 Pages: 1020-1076
  • DOI: 10.1111/jdi.13306
  • Peer Reviewed / Open Access
• [Journal Article] Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes. (2020)
  • Author(s): Morita Y, Senokuchi T, Yamada S, Wada T, Furusho T, Matsumura T, Ishii N, Nishida S, Nishida S, Motoshima H, Komohara Y, Yamagata K, Araki E.
  • Journal Title: BMJ Open Diabetes Res Care Volume: 8(1) Issue: 1 Pages: e001578-e001578
  • DOI: 10.1136/bmjdrc-2020-001578
  • Peer Reviewed / Open Access
• [Journal Article] Mild electrical stimulation with heat shock attenuates renal pathology in adriamycin-induced nephrotic syndrome mouse model (2020)
  • Author(s): Teramoto Keisuke、Tsurekawa Yu、Suico Mary Ann、Kaseda Shota、Omachi Kohei、Yokota Tsubasa、Kamura Misato、Piruzyan Mariam、Kondo Tatsuya、Shuto Tsuyoshi、Araki Eiichi、Kai Hirofumi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 18719-18719
  • DOI: 10.1038/s41598-020-75761-8
  • Peer Reviewed / Open Access
• [Journal Article] Rapid and dramatic glucose‐lowering effect of bromocriptine in an inadequately controlled type2 diabetes patient with prolactinoma (2020)
  • Author(s): Igata Motoyuki、Yagi Yoshitaka、Hanatani Satoko、Sakaguchi Masaji、Ishii Norio、Yoshinaga Kayo、Kawashima Junji、Motoshima Hiroyuki、Araki Eiichi
  • Journal Title: Journal of Diabetes Investigation Volume: 12 Issue: 4 Pages: 668-671
  • DOI: 10.1111/jdi.13369
  • Peer Reviewed / Open Access
• [Journal Article] Hypoglycemia Induces Mitochondrial Reactive Oxygen Species Production Through Increased Fatty Acid Oxidation and Promotes Retinal Vascular Permeability in Diabetic Mice (2020)
  • Author(s): Yoshinaga Ayaka、Kajihara Nobuhiro、Kukidome Daisuke、Motoshima Hiroyuki、Matsumura Takeshi、Nishikawa Takeshi、Araki Eiichi
  • Journal Title: Antioxidants & Redox Signaling Volume: Online ahead of print Issue: 16 Pages: 1245-1259
  • DOI: 10.1089/ars.2019.8008
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of an amplicon-based custom gene panel for the diagnosis of hereditary tumors. (2020)
  • Author(s): Shinriki S, Maeshiro M, Shimamura K, Kawashima J, Araki E, Ibusuki M, Yamamoto Y, Iwase H, Miyamoto Y, Baba H, Yamaguchi M, Matsui H.
  • Journal Title: Neoplasma Volume: － Issue: 04 Pages: 898-908
  • DOI: 10.4149/neo_2020_190918n925
  • Peer Reviewed / Open Access
• [Journal Article] The amount of residual incretin regulates pancreatic β-cell function and glucose homeostasis. (2020)
  • Author(s): Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Sato M, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E.
  • Journal Title: Internal Medicine Volume: Online ahead of print
  • NAID: 130008033306
  • Peer Reviewed / Open Access
• [Journal Article] Long‐term efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes: pooled 52‐week outcomes from the DEPICT ‐1 and ‐2 studies (2020)
  • Author(s): Phillip Moshe、Mathieu Chantal、Lind Marcus、Araki Eiichi、Bartolo Paolo、Bergenstal Richard、Heller Simon、Hansen Lars、Scheerer Markus Florian、Thoren Fredrik、Arya Niki、Xu John、Iqbal Nayyar、Dandona Paresh、DEPICT‐1 and DEPICT‐2 Investigators
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 23 Issue: 2 Pages: 549-560
  • DOI: 10.1111/dom.14248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society (2020)
  • Author(s): Araki Eiichi、the directors of the JCS, JDS、Tanaka Atsushi、Inagaki Nobuya、Ito Hiroshi、Ueki Kohjiro、Murohara Toyoaki、Imai Kenjiro、Sata Masataka、Sugiyama Takehiro、Ishii Hideki、Yamane Shunsuke、Kadowaki Takashi、Komuro Issei、Node Koichi
  • Journal Title: Diabetology International Volume: 12 Issue: 1 Pages: 1-51
  • DOI: 10.1007/s13340-020-00471-5
  • NAID: 40022457377
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetics and pharmacodynamics of dapagliflozin in combination with insulin in Japanese patients with type 1 diabetes (2019)
  • Author(s): Watada Hirotaka、Shiramoto Masanari、Ueda Shinya、Tang Weifeng、Asano Michiko、Thor?n Fredrik、Kim Hyosung、Yajima Toshitaka、Boulton David W.、Araki Eiichi
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 4 Pages: 876-882
  • DOI: 10.1111/dom.13593
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Efficacy and Safety of Pemafibrate, a Novel SelectivePeroxisome Proliferator-Activated Receptor-α Modulator (SPPARMα),in Dyslipidemic Patients with Renal Impairment (2019)
  • Author(s): Yokote K, Yamashita S, Arai H, Araki E, Suganami H, Ishibashi S, Of TheK-Study Group OB
  • Journal Title: Int J Mol Sci Volume: 20(3) Issue: 3 Pages: 706-706
  • DOI: 10.3390/ijms20030706
  • Peer Reviewed / Open Access
• [Journal Article] Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus (2019)
  • Author(s): Kondo Tatsuya、Nakamura Miwa、Kawashima Junji、Matsumura Takeshi、Ohba Takashi、Yamaguchi Munekage、Katabuchi Hidetaka、Araki Eiichi
  • Journal Title: Endocrine Journal Volume: 66 Issue: 3 Pages: 253-258
  • DOI: 10.1507/endocrj.EJ18-0496
  • NAID: 130007626248
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Impact of hepatic HSP72 on insulin signaling (2019)
  • Author(s): Kitano Sayaka、Kondo Tatsuya、Matsuyama Rina、Ono Kaoru、Goto Rieko、Takaki Yuki、Hanatani Satoko、Sakaguchi Masaji、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Kai Hirofumi、Araki Eiichi
  • Journal Title: American Journal of Physiology-Endocrinology and Metabolism Volume: 316 Issue: 2 Pages: E305-E318
  • DOI: 10.1152/ajpendo.00215.2018
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52‐week data from the PROVIDE study (2019)
  • Author(s): Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 7 Pages: 1737-1744
  • DOI: 10.1111/dom.13686
  • Peer Reviewed / Open Access
• [Journal Article] Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets (2019)
  • Author(s): Goto Rieko、Kondo Tatsuya、Ono Kaoru、Kitano Sayaka、Miyakawa Nobukazu、Watanabe Takuro、Sakaguchi Masaji、Sato Miki、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Shimoda Seiya、Araki Eiichi
  • Journal Title: Journal of Clinical Medicine Volume: 8 Issue: 5 Pages: 674-674
  • DOI: 10.3390/jcm8050674
  • Peer Reviewed / Open Access
• [Journal Article] Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ (2019)
  • Author(s): Murakami-Nishida Saiko、Matsumura Takeshi、Senokuchi Takafumi、Ishii Norio、Kinoshita Hiroyuki、Yamada Sarie、Morita Yutaro、Nishida Shuhei、Motoshima Hiroyuki、Kondo Tatsuya、Komohara Yoshihiro、Araki Eiichi
  • Journal Title: Atherosclerosis Volume: 286 Pages: 30-39
  • DOI: 10.1016/j.atherosclerosis.2019.04.229
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) and long-acting second-generation basal insulin (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes: a pilot, randomized, controlled study (2019)
  • Author(s): Shimoda Seiya、Sakamoto Wakana、Hokamura Ayaka、Matsuo Yasuto、Sekigami Taiji、Ichimori Shinji、Iwashita Shinsuke、Ishii Norio、Otsu Kae、Yoshimura Ryohei、Nishiyama Toshihiko、Sakaguchi Masaji、Nishida Kenro、Araki Eiichi
  • Journal Title: Endocrine Journal Volume: 66 Issue: 8 Pages: 745-752
  • DOI: 10.1507/endocrj.EJ19-0179
  • NAID: 130007696455
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Short-Term Cost-Effectiveness of Switching to Insulin Degludec in Japanese Patients With Type 2 Diabetes Receiving Basal-Bolus Therapy (2019)
  • Author(s): Jakob Langer 1, Michael L Wolden 2, Seiya Shimoda 3, Miki Sato 4, Eiichi Araki 4
  • Journal Title: Diabetes Therapy Volume: 10 (4) Issue: 4 Pages: 1347-1356
  • DOI: 10.1007/s13300-019-0635-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Superior efficacy with a fixed‐ratio combination of insulin degludec and liraglutide (IDegLira) compared with insulin degludec and liraglutide in insulin‐na?ve Japanese patients with type 2 diabetes in a phase 3, open‐label, randomized trial (2019)
  • Author(s): Kaku Kohei、Araki Eiichi、Tanizawa Yukio、Ross Agner Bue、Nishida Tomoyuki、Ranthe Mattis、Inagaki Nobuya
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 12 Pages: 2674-2683
  • DOI: 10.1111/dom.13856
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial (2019)
  • Author(s): Zinman Bernard、Aroda Vanita R.、Buse John B.、Cariou Bertrand、Harris Stewart B.、Hoff S?ren Tetens、Pedersen Karen Boje、Tarp-Johansen Mads Jeppe、Araki Eiichi
  • Journal Title: Diabetes Care Volume: 42 Issue: 12 Pages: 2262-2271
  • DOI: 10.2337/dc19-0898
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential predictive factors for cardiovascular events in patients with or without cancer history. (2019)
  • Author(s): Sueta D, Tabata N, Ikeda S, Saito Y, Ozaki K, Sakata K, Matsumura T, Yamamoto-Ibusuki M, Murakami Y, Jodai T, Fukushima S, Yoshida N, Kamba T, Araki E, Iwase H, Fujii K, Ihn H, Kobayashi Y, Minamino T, Yamagishi M, Maemura K, Baba H, Matsui K, Tsujita K.
  • Journal Title: Medicine (Baltimore). Volume: 98 Issue: 44 Pages: e17602-e17602
  • DOI: 10.1097/md.0000000000017602
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Efficacy and Safety of Linagliptin in a Japanese Population With Type 2 Diabetes Aged over 60 Years Treated With Basal Insulin: A Randomised Trial (2019)
  • Author(s): Eiichi Araki, Yuriko Unno, Yuko Tanaka, Wataru Sakamoto, Yuki Miyamoto
  • Journal Title: Advances in Therapy Volume: 36 (10) Issue: 10 Pages: 2697-2711
  • DOI: 10.1007/s12325-019-01065-7
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination (2019)
  • Author(s): Yamashita、Arai、Yokote、Araki、Matsushita、Nojima、Suganami、Ishibashi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 22 Pages: 5537-5537
  • DOI: 10.3390/ijms20225537
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of dapagliflozin in Japanese patients with inadequately controlled type 1 diabetes (DEPICT‐5): 52‐week results from a randomized, open‐label, phase III clinical trial (2019)
  • Author(s): Araki Eiichi、Watada Hirotaka、Uchigata Yasuko、Tomonaga Osamu、Fujii Hitomi、Ohashi Hiroshi、Okabe Tadashi、Asano Michiko、Thoren Fredrik、Kim Hyosung、Yajima Toshitaka、Langkilde Anna Maria
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 22 Issue: 4 Pages: 540-548
  • DOI: 10.1111/dom.13922
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Pemafibrate Versus Fenofibrate in Patients with High Triglyceride and Low HDL Cholesterol Levels: A Multicenter, Placebo-Controlled, Double-Blind, Randomized Trial (2018)
  • Author(s): Arai Hidenori、Yamashita Shizuya、Yokote Koutaro、Araki Eiichi、Suganami Hideki、Ishibashi Shun、on behalf of the K-877 Study Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 6 Pages: 521-538
  • DOI: 10.5551/jat.44412
  • NAID: 130007382568
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of the 2016 Kumamoto Earthquake on glycemic control in patients with diabetes (2018)
  • Author(s): Kondo Tatsuya、Miyakawa Nobukazu、Motoshima Hiroyuki、Hanatani Satoko、Ishii Norio、Igata Motoyuki、Yoshinaga Kayo、Kukidome Daisuke、Senokuchi Takafumi、Kawashima Junji、Furukawa Noboru、Matsumura Takeshi、Araki Eiichi
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 2 Pages: 521-530
  • DOI: 10.1111/jdi.12891
  • Peer Reviewed / Open Access
• [Journal Article] The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report (2018)
  • Author(s): Kondo Tatsuya、Nakamura Miwa、Kitano Sayaka、Kawashima Junji、Matsumura Takeshi、Ohba Takashi、Yamaguchi Munekage、Katabuchi Hidetaka、Araki Eiichi
  • Journal Title: BMC Endocrine Disorders Volume: 18 Issue: 1 Pages: 4-4
  • DOI: 10.1186/s12902-018-0234-6
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (2018)
  • Author(s): Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
  • Journal Title: Diabetes Care Volume: 41 Issue: 3 Pages: 538-546
  • DOI: 10.2337/dc17-1589
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial (2018)
  • Author(s): Shun Ishibashi, Hidenori Arai, Koutaro Yokote, Eiichi Araki, Hideki Suganami, Shizuya Yamashita
  • Journal Title: J Clin Lipidol. Volume: 12 Issue: 1 Pages: 173-184
  • DOI: 10.1016/j.jacl.2017.10.006
  • Peer Reviewed / Open Access
• [Journal Article] Identification of microRNA that represses IRS-1 expression in liver. (2018)
  • Author(s): Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E
  • Journal Title: PLoS One Volume: 13 Issue: 1 Pages: 0191553-0191553
  • DOI: 10.1371/journal.pone.0191553
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis. (2018)
  • Author(s): Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 印刷中 Issue: 5 Pages: 994-1006
  • DOI: 10.1161/atvbaha.117.310320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Japanese Clinical Practice Guideline for Diabetes 2016. (2018)
  • Author(s): Haneda M, Noda M, Origasa H, Noto H, Yabe D, Fujita Y, Goto A, Kondo T, Araki E
  • Journal Title: J Diabetes Investig. Volume: 9 Issue: 3 Pages: 657-697
  • DOI: 10.1111/jdi.12810
  • NAID: 120006469171
  • Peer Reviewed / Open Access
• [Journal Article] Effects of a novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate (K-877), on hepatic and peripheral glucose uptake in patients with hypertriglyceridemia and insulin resistance (2018)
  • Author(s): Matsuba Ikuro、Matsuba Ren、Ishibashi Shun、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Suganami Hideki、Araki Eiichi
  • Journal Title: Journal of Diabetes Investigation Volume: - Issue: 6 Pages: 0-0
  • DOI: 10.1111/jdi.12845
  • Peer Reviewed / Open Access
• [Journal Article] A Rare Case of Thyrotropin-Secreting Pituitary Adenoma Coexisting with Papillary Thyroid Carcinoma Presenting with Visual Disturbance without Hyperthyroidism (2018)
  • Author(s): Inoue Hirotaka、Shinojima Naoki、Ueda Ryuta、Yamamoto Keizo、Ishii Norio、Igata Motoyuki、Kawashima Junji、Araki Eiichi、Iwase Hirotaka、Mikami Yoshiki、Yano Shigetoshi、Mukasa Akitake
  • Journal Title: World Neurosurgery Volume: 119 Pages: 394-399
  • DOI: 10.1016/j.wneu.2018.07.274
  • Peer Reviewed / Open Access
• [Journal Article] Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial (2018)
  • Author(s): Rodbard Helena W、Lingvay Ildiko、Reed John、de la Rosa Raymond、Rose Ludger、Sugimoto Danny、Araki Eiichi、Chu Pei-Ling、Wijayasinghe Nelun、Norwood Paul
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 103 Issue: 6 Pages: 2291-2301
  • DOI: 10.1210/jc.2018-00070
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Dapagliflozin in Patients With Inadequately Controlled Type 1 Diabetes (the DEPICT-2 Study): 24-Week Results From a Randomized Controlled Trial (2018)
  • Author(s): Mathieu Chantal、Dandona Paresh、Gillard Pieter、Senior Peter、Hasslacher Christoph、Araki Eiichi、Lind Marcus、Bain Stephen C.、Jabbour Serge、Arya Niki、Hansen Lars、Thor?n Fredrik、Langkilde Anna Maria
  • Journal Title: Diabetes Care Volume: 41 Issue: 9 Pages: 1938-1946
  • DOI: 10.2337/dc18-0623
  • Peer Reviewed
• [Journal Article] Impacts of tight multifactorial intervention in patients with type 2 diabetes: Implications from the Japan Diabetes Outcome Intervention Trial 3 (2018)
  • Author(s): Araki Eiichi、Senokuchi Takafumi、Furukawa Noboru
  • Journal Title: Journal of Diabetes Investigation Volume: 9 Issue: 5 Pages: 1022-1024
  • DOI: 10.1111/jdi.12872
  • Peer Reviewed / Open Access
• [Journal Article] Effects of pemafibrate (K-877) on cholesterol efflux capacity and postprandial hyperlipidemia in patients with atherogenic dyslipidemia (2018)
  • Author(s): Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Araki Eiichi、Suganami Hideki、Ishibashi Shun
  • Journal Title: Journal of Clinical Lipidology Volume: 12 Issue: 5 Pages: 747-750
  • DOI: 10.1016/j.jacl.2018.06.010
  • Peer Reviewed / Open Access
• [Journal Article] One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance (2018)
  • Author(s): Nishikawa Takeshi、Ono Keiko、Hashimoto Shoko、Kinoshita Hiroyuki、Watanabe Takuro、Araki Hirotaka、Otsu Kae、Sakamoto Wakana、Harada Masahiro、Toyonaga Tetsushi、Kawakami Shoichi、Fukuda Jyunichiro、Haga Yoshio、Kukidome Daisuke、Takahashi Takeshi、Araki Eiich
  • Journal Title: Journal of Diabetes Investigation Volume: 9 Issue: 6 Pages: 1370-1377
  • DOI: 10.1111/jdi.12848
  • Peer Reviewed / Open Access
• [Presentation] Regulation of Phosphorylation Status in Insulin Signaling via alpha4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics. (2020)
  • Author(s): Sakaguchi M, Okagawa S, Okubo Y, Kitano S, Igata M, Kondo T, Araki E.
  • Organizer: The 80th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] Activation of Heat Shock Response Ameliorates Nonalcoholic Fatty Liver Disease Biomarkers. (2020)
  • Author(s): Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E.
  • Organizer: The 80th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] Inhibition of tissue macrophage proliferation improves insulin resistance in liver and adipose tissue. (2020)
  • Author(s): Wada T, Senokuchi T, Yamada S, Morita Y, Motoshima H, Ishi N, Matsumura T, Araki E.
  • Organizer: The 80th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] The essential role of the α4 for insulin signalling in metabolic regulation and maintenance of brown adipocyte. (2020)
  • Author(s): Sakaguchi M, Okagawa S, Okubo Y, Igata M, Kondo T, Araki E.
  • Organizer: 56th Annual Meetng of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] JDS・JCS合同ステートメントの現状と今後. (2020)
  • Author(s): 荒木栄一
  • Organizer: 第63回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 脂肪酸酸化を介した低血糖誘導ミトコンドリア由来活性酸素種 (mtROS) の血液網膜関門への影響の検討 (2020)
  • Author(s): 吉永礼香，梶原伸宏，久木留大介，本島寛之，松村剛，西川武志，荒木栄一
  • Organizer: 第35回日本糖尿病合併症学会・第26回日本糖尿病眼学会総会
• [Presentation] DPP-4阻害薬リナグリプチンによるマクロファージの極性変化を介した糖尿病大血管症進展抑制効果の検討. (2020)
  • Author(s): 松村 剛，西田周平，西田彩子，瀬ノ口隆文，石井規夫，福田一起, 山田沙梨恵, 守田雄太郎，和田敏明, 八木善崇，荒木栄一
  • Organizer: 第35回日本糖尿病合併症学会
• [Presentation] 肝および脂肪組織インスリン抵抗性における組織マクロファージ増殖の意義の検討. (2020)
  • Author(s): 瀬ノ口 隆文、山田 沙梨恵、守田 雄太郎、和田 敏明、古荘 達哉、松村 剛、荒木 栄一
  • Organizer: 第35回日本糖尿病合併症学会
• [Presentation] リジン脱メチル化酵素LSD1は骨格筋の可塑性を制御する. (2020)
  • Author(s): 荒木裕貴, 日野信次朗, 阿南 浩太郎, 興梠 健作, 髙瀬 隆太, 荒木 栄一, 中尾光善
  • Organizer: 第70回日本体質医学会総会
• [Presentation] DPP-4阻害薬リナグリプチンによるマクロファージM2誘導効果の機序解析. (2020)
  • Author(s): 西田周平, 松村 剛, 西田彩子, 瀬ノ口隆文, 石井規夫, 山田沙梨恵, 守田雄太郎, 和田敏明, 八木喜崇, 荒木栄一
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
• [Presentation] デュラグルチドによる糖尿病大血管症進展抑制効果の解析. (2020)
  • Author(s): 八木喜崇, 松村 剛, 西田周平, 瀬ノ口隆文, 石井規夫, 山田沙梨恵, 西田彩子, 守田雄太郎, 和田敏明, 荒木栄一
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
• [Presentation] メタボリックシンドロームと2型糖尿病における温熱微弱電流療法のNAFLD改善効果. (2020)
  • Author(s): 宮川展和，近藤龍也，北野さやか，渡邊拓郎，後藤理英子，Mary Ann Suico，佐藤美希，髙木優樹，阪口雅司，井形元維，河島淳司，本島寛之，松村剛，甲斐広文，荒木栄一
  • Organizer: 第70回日本体質医学会総会
• [Presentation] 膵α細胞におけるHeat Shock Protein 72(HSP72)の関与. (2020)
  • Author(s): 渡邊拓郎, 近藤龍也，宮川展和，吉積臨太郎，北野さやか，井形元維，河島淳司，瀬ノ口隆文，松村剛，荒木栄一
  • Organizer: 第70回日本体質医学会総会.
• [Presentation] 白色および褐色脂肪組織のインスリン抵抗性に関わる新規経路α4 の全身代謝制御の解析. (2020)
  • Author(s): 阪口雅司，岡川章太，大久保侑馬，北野さやか，井形元維，河島淳司，近藤龍也，荒木栄一
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] DPP-4阻害薬リナグリプチンは大動脈においてM2 MΦを増加させ動脈硬化進展抑制作用を発揮する. (2020)
  • Author(s): 西田周平, 松村 剛, 西田彩子, 瀬ノ口隆文, 石井規夫, 守田雄太郎, 八木善崇, 和田敏明, 荒木栄一
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] 低血糖による糖尿病網膜症の発症・進展に対するミトコンドリア由来活性酸素種 (mtROS) の関与. (2020)
  • Author(s): 吉永礼香，梶原伸宏，久木留大介，本島寛之，松村剛，西川武志，荒木栄一
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] デュラグルチドによる糖尿病大血管症進展抑制効果. (2020)
  • Author(s): 八木喜崇, 松村 剛, 西田周平, 瀬ノ口隆文, 石井規夫, 山田沙梨恵, 西田彩子, 竹下 実, 吉永智昭, 荒木栄一
  • Organizer: 第58回日本糖尿病学会九州地方会.
• [Presentation] 温熱微弱電流療法のメタボリックシンドロームと2型糖尿病におけるNAFLD改善効果 (2020)
  • Author(s): 宮川展和、近藤龍也、北野さやか、渡邊拓郎、後藤理英子、Mary Ann Suico、佐藤美希、髙木優樹、阪口雅司、井形元維、河島淳司、本島寛之、松村剛、甲斐広文、荒木栄一
  • Organizer: 第58回日本糖尿病学会九州地方会
• [Presentation] Effects of linagliptin on macrophages and on progression of atherosclerosis in high fat-fed apoE-deficient mice, (2019)
  • Author(s): Nishida S, Matsumura T, Senokuchi T, Ishii N, Murakami-Nishida S, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
  • Organizer: The 11th Scientific Meeting of the Asian Association for the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] Unique role of the α4 component for S6-kinase activity in Metabolic Regulation and anti- Apoptotic effect in Brown Adipose Tissue. (2019)
  • Author(s): Sakaguchi M, Okagawa S, Kitano S, Kondo T, Araki E:
  • Organizer: The 79th ADA scientific meeting.
  • Int'l Joint Research
• [Presentation] Oral semaglutide as add-on to insulin in T2D: PIONEER 8 (2019)
  • Author(s): Zinman B, Aroda VR, Buse JB, Cariou B, Harris SB, Hoff ST, Pedersen KB, Tarp-Johansen MJ, Araki E
  • Organizer: The 79th ADA scientific meeting.
  • Int'l Joint Research
• [Presentation] The Hepatic Role of Heat Shock Protein 72 in the Pathogenesis of Type 2 Diabetes. (2019)
  • Author(s): Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E
  • Organizer: The 79th ADA Scientific Meeting.
  • Int'l Joint Research
• [Presentation] Pioglitazone Suppresses Macrophage Proliferation in Apolipoprotein-e Deficient Mice by Activating PPARγ. (2019)
  • Author(s): Murakami-Nishida S, Matsumura T, Nishida S, Senokuchi T, Ishi N, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
  • Organizer: The 79th ADA Scientific Meeting.
  • Int'l Joint Research
• [Presentation] Linagliptin induces M2 macrophage polarization and suppresses progression of atherosclerosis in high fat-fed apoE-deficient mice. (2019)
  • Author(s): Nishida S, Matsumura T, Senokuchi T, Ishii N, Murakami-Nishida S, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
  • Organizer: The 79th ADA Scientific Meeting.
  • Int'l Joint Research
• [Presentation] FoxK1 and FoxK2 are positive regulators for IR and IGF1R signalling in cell proliferation and metabolism. (2019)
  • Author(s): Sakaguchi M, Araki E, Mann M, Enerba S, Kahn CR
  • Organizer: 55th Annual Meeting of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] The organ cross talk in the regulation of glucose homeostasis through heat shock protein 72 expression. (2019)
  • Author(s): Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E
  • Organizer: 55th Annual Meeting of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ. (2019)
  • Author(s): Matsumura T, Nishida S.M, Nishida S, Senokuchi T, Ishii N, Morita Y, Wada T, Motoshima H, Kondo T, Arak E;
  • Organizer: 55th Annual Meeting of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] Role of Tissue Macrophages Proliferation in Insulin Resistance in the Liver and Adipose tissue. (2019)
  • Author(s): Wada T, Senokuchi T, Yamada S, Morita Y, Furusho T, Motoshima H, Ishi N, Matsumura T, Araki E
  • Organizer: International Diabetes Federation Congress 2019
  • Int'l Joint Research
• [Presentation] 糖尿病患者における肝細胞癌発生の実態調査. (2019)
  • Author(s): 松村剛，瀬ノ口隆文，建石良介，窪田直人，小池和彦，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 熊本発ブルーサークルメニューの開発とその効用． (2019)
  • Author(s): 近藤龍也
  • Organizer: 第7回アフリカ開発会議 ポストフォーラム in 熊本.
• [Presentation] 災害時の糖尿病患者支援~学会・協会の取り組みより (2019)
  • Author(s): 瀬ノ口隆文，本島 寛之，近藤龍也，荒木 栄一
  • Organizer: 第57回日本糖尿病学会 九州地方会
• [Presentation] 糖尿病治療薬の心/腎保護効果. (2019)
  • Author(s): 荒木栄一
  • Organizer: 日本内科学会学術集会第47回内科学の展望
  • Invited
• [Presentation] physical medicineによる2型糖尿病新規治療法の開発. (2019)
  • Author(s): 近藤龍也
  • Organizer: 第38回日本認知症学会学術集会.
  • Invited
• [Presentation] 糖尿病診療の Update 合併症の発症・進展阻止のために (2019)
  • Author(s): 荒木栄一
  • Organizer: 第66回九州支部生涯教育講演会
  • Invited
• [Presentation] ピオグリタゾンによるマクロファージ増殖抑制効果を介した糖尿病大血管合併症進展抑制効果. (2019)
  • Author(s): 松村剛，西田彩子，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，西田周平，和田敏明, 佐藤美希，本島寛之，近藤龍也，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病患者における熊本地震被災後2年間での代謝障害に関する検討. (2019)
  • Author(s): 髙木将太朗, 松村剛, 藤本祐輔, 西野有希, 本郷恵美, 藤本有紀, 山田沙梨恵, 荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 褐色脂肪組織におけるインスリンシグナル新規標的分子FoxK1/2の研究. (2019)
  • Author(s): 阪口雅司, C Ronald Kahn, 荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] SGLT2阻害薬によるマクロファージ活性制御の機序解明. (2019)
  • Author(s): 西田彩子，松村 剛，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，西田周平，和田敏明，佐藤美希，本島寛之，近藤龍也，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] Heat Shock Protein 72 ノックアウトマウスにおける糖代謝異常発生機序の解明. (2019)
  • Author(s): 北野さやか，近藤龍也，渡邊拓郎，宮川展和，小野薫，花谷聡子，阪口雅司，後藤理英子，井形元維，河島淳司，本島寛之，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 膵α細胞の鉱質コルチコイドレセプタ―は膵島におけるIL-6とGLP-1分泌を制御する (2019)
  • Author(s): 後藤理英子, 近藤龍也, 荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] ピオグリタゾンの抗動脈硬化作用としてのマクロファージ増殖抑制効果の解析. (2019)
  • Author(s): 西田彩子，松村剛，西田周平，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，和田敏明，荒木栄一
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
• [Presentation] DPP-4阻害薬リナグリプチンによるM2マクロファージ誘導効果の解析 (2019)
  • Author(s): 西田周平，松村剛，西田彩子，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，和田敏明，荒木栄一
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
• [Presentation] DPP-4阻害薬によるマクロファージの極性変化を介した抗動脈硬化作用機序の解明 (2019)
  • Author(s): 西田周平，松村 剛，西田彩子，瀬ノ口隆文，荒木栄一
  • Organizer: 第69回日本体質医学会総会
• [Presentation] 全大腸切除後の高血糖にGLP-1製剤が有効であった症例の病態解明 (2019)
  • Author(s): 近藤龍也、井形元維, 河島淳司、瀬ノ口隆文、松村剛、本島寛之、荒木栄一
  • Organizer: 第57回日本糖尿病学会九州地方会.
• [Presentation] Impacts of the Kumamoto Earthquake 2016 on glycemic control in diabetic patients (2018)
  • Author(s): Kondo T, Miyakawa N, Motoshima H, Ishii N, Igata M, Yoshinaga K, Kukidome D, Senokuchi T, Kawashima J, Matsumura T, Araki E
  • Organizer: The 78th ADA Scientific Meetng
  • Int'l Joint Research
• [Presentation] Pharmacokinetics (PK) and Pharmacodynamics (PD) of Dapagliflozin (DAPA) in Combination with Insulin in Japanese Patients with T1D (2018)
  • Author(s): Watada H, Shiramoto M, Ueda S, Tang W, Asano M, Thoren F, Kim H, Yajima T, Boulton DW, Araki E
  • Organizer: The 78th ADA Scientific Meetng
  • Int'l Joint Research
• [Presentation] 2型糖尿病の成因と病態Update (2018)
  • Author(s): 荒木栄一
  • Organizer: 第52回糖尿病学の進歩.
  • Invited
• [Presentation] 糖尿病診療の最前線. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第115回日本内科学会総会・講演会
  • Invited
• [Presentation] HSP72を標的としたインスリン抵抗性・肥満の治療 (2018)
  • Author(s): 荒木栄一
  • Organizer: 第39回日本肥満学会
• [Presentation] 糖尿病治療の新たな展望. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第68回日本体質医学会総会
• [Presentation] 糖尿病治療Update;合併症の発症・進展阻止のために (2018)
  • Author(s): 荒木栄一
  • Organizer: 第39回日本肥満学会.
• [Presentation] ヒートパッドによる熱ストレス応答経路活性化. (2018)
  • Author(s): 近藤龍也
  • Organizer: 第56回日本糖尿病学会 九州地方会
• [Presentation] 日本人2型糖尿病患者における，ベースラインHbA1c 別のセマグルチドの有効性の検討. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 「平成28年熊本地震」における糖尿病患者の血糖コントロールとその変動規定因子の検討. (2018)
  • Author(s): 近藤龍也, 宮川展和, 石井則夫, 吉永佳代, 井形元維, 久木留大介, 河島淳司, 瀬ノ口隆文, 松村剛, 本島寛之, 荒木栄一
  • Organizer: 第61回日本糖尿病学会年次学術総会
• [Presentation] 「平成28年熊本地震」における糖尿病患者の血糖管理状況とその規定因子. (2018)
  • Author(s): 近藤龍也, 宮川展和, 石井則夫, 吉永佳代, 井形元維, 久木留大介, 河島淳司, 瀬ノ口隆文, 松村剛, 本島寛之, 荒木栄一
  • Organizer: 第115回日本内科学会総会・講演会
• [Presentation] 妊娠悪阻による低K血症は横紋筋融解症と腎性尿崩症の原因となる. (2018)
  • Author(s): 近藤龍也,河島淳司,中村美和, 荒木栄一
  • Organizer: 第28回臨床内分泌代謝Update
• [Book] 臨床と研究. [糖尿病診療ガイドライン2019の要点] (2021)
  • Author(s): 荒木栄一
  • Total Pages: 108
  • Publisher: 大道学館
• [Book] 医学の歩み [日本糖尿病学会(JDS)と日本循環器学会(JCS)による合同コンセンサスステートメント] (2021)
  • Author(s): 荒木栄一
  • Total Pages: 98
  • Publisher: 医歯薬出版
• [Book] 医学の歩み [成熟脂肪組織および脂肪前駆細胞におけるインスリン/IGF1 シグナルの役割. ] (2020)
  • Author(s): 阪口雅司, 大久保侑馬, 岡川章太, 荒木栄一
  • Total Pages: 120
  • Publisher: 医歯薬出版
• [Book] Medical Tribune [糖尿病診療ガイドラインの注目点 3年ぶりに改定] (2020)
  • Author(s): 荒木栄一
  • Total Pages: 80
  • Publisher: Medical Tribune
• [Book] 日本内科学会雑誌 [全身を診るⅡ 1)糖尿病治療薬の心/腎保護効果] (2020)
  • Author(s): 荒木栄一
  • Total Pages: 2002
  • Publisher: 杏林舍
• [Book] 新臨床内科学 [代謝・栄養疾患を理解するためのポイント] (2020)
  • Author(s): 荒木栄一
  • Total Pages: 109
  • Publisher: 医学書院
• [Book] Current Therapy 2020 [日本糖尿病学会の立場] (2020)
  • Author(s): 荒木栄一
  • Total Pages: 99
  • Publisher: ライフメディコム
• [Book] 糖尿病・内分泌代謝科 [糖尿病診療ガイドライン2019-改定のポイント] (2020)
  • Author(s): 荒木栄一, 石井規夫, 河島淳司, 近藤龍也, 松村剛
  • Total Pages: 59
  • Publisher: 科学評論社
• [Book] 日本臨床 糖尿病診療update [糖尿病診療ガイドライン2019の活用] (2020)
  • Author(s): 荒木栄一
  • Total Pages: 192
  • Publisher: 日本臨床社
• [Book] DIABETES JOURNAL（糖尿病と代謝）[インスリン治療の進歩] (2020)
  • Author(s): 吉永智昭, 荒木栄一
  • Total Pages: 159
  • Publisher: ディアベテス・ジャーナル社
• [Book] Medical Practice. [糖尿病診療ガイドライン2019の活用ポイント] (2020)
  • Author(s): 荒木栄一
  • Total Pages: 138
  • Publisher: 文光堂
• [Book] 日本臨牀 別冊「内分泌症候群（第3版）Ⅳ-その他の内分泌疾患を含めて-」Ⅷ．糖代謝９．インスリン受容体異常症(A型，B型) (2019)
  • Author(s): 1.阪口雅司, 荒木栄一
  • Total Pages: 375
  • Publisher: 日本臨牀社
• [Book] 糖尿病最新の治療2019-2021 (2019)
  • Author(s): 門脇 孝、荒木 栄一、綿田 裕孝
  • Total Pages: 348
  • Publisher: 南江堂
  • ISBN: 4524245561
• [Book] 万病のもと！糖尿病徹底対策 これが原因！NHKテキストきょうの健康 (2019)
  • Author(s): 荒木栄一
  • Total Pages: 126
  • Publisher: NHK出版
• [Book] 臨床研究から日常診療応用の実際と限界. 糖尿病UP DATE賢島セミナー2018 35 臨床研究から日常診療へのシームレスな活用 (2019)
  • Author(s): 荒木栄一
  • Total Pages: 256
  • Publisher: メディカル・ジャーナル社
  • ISBN: 9784908437205
• [Book] 特集／激増する糖尿病の診療最前線 糖尿病診断の進め方. (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 7
  • Publisher: 大道学館 臨床と研究.
• [Book] 脂肪細胞におけるインスリン受容体の役割 (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 7
  • Publisher: 診断と治療社
• [Book] TOPICS 誘導可能な脂肪特異的インスリン受容体欠損マウスの解析 Diabetes Journal (糖尿病と代謝) (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 2
  • Publisher: Diabetes Journal
• [Book] ADAガイドライン2018-米国での動き (2018)
  • Author(s): 荒木栄一, 阪口雅司, 瀬ノ口隆文
  • Total Pages: 4
  • Publisher: Diabetes Journal
• [Book] 新しい脂質異常症治療薬としての selective peroxisome proliferator-activated receptor α modulator (SPPARM α) とその可能性 (2018)
  • Author(s): 荒木栄一, 瀬ノ口隆文
  • Total Pages: 4
  • Publisher: 医歯薬出版
• [Book] 高中性脂肪血症治療の重要性：糖尿病合併症講師決勝の観点から (2018)
  • Author(s): 荒木栄一, 益崎裕章, 小田原雅人, 横手幸太郎
  • Total Pages: 2
  • Publisher: 日経メディカル
• [Book] 万病のもと！糖尿病徹底対策 (2018)
  • Author(s): 荒木栄一
  • Total Pages: 8
  • Publisher: NHKテキストきょうの健康
• [Book] 進化する糖尿病医療. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 1
  • Publisher: BIO Clinica
• [Book] 糖尿病診療の最前線. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 8
  • Publisher: 日本内科学会雑誌
• [Book] 糖尿病の治療とは (2018)
  • Author(s): 荒木栄一
  • Total Pages: 4
  • Publisher: 別冊NHKテキストきょうの健康
• [Book] 今日から始める自己管理 (2018)
  • Author(s): 荒木栄一
  • Total Pages: 6
  • Publisher: 別冊NHKテキストきょうの健康
• [Book] 編集の言葉. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 1
  • Publisher: Diabetes Care 日本語版
• [Book] 日本臨牀 別冊「内分泌症候群（第3版）Ⅳ-その他の内分泌疾患を含めて-」Ⅷ．糖代謝９．インスリン受 容体異常症(A型，B型)日本臨床 (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 5
  • Publisher: 日本臨牀
• [Book] 平成28年熊本地震」における糖尿病患者の血糖コントロールに関わる因子の検討. (2018)
  • Author(s): 近藤龍也、宮川展和、本島寛之、花谷聡子、石井則夫、井形元維、吉永佳代、久木留大介、瀬ノ口隆文、河島淳司、松村剛、荒木栄一
  • Total Pages: 5
  • Publisher: 日本体質医学学会雑誌
• [Remarks] 熊本大学大学院生命科学研究部 代謝内科学分野 熊本大学病院 糖尿病・代謝・内分泌内科
  • URL: https://metmed-kumamoto.net/
• [Remarks] 熊本大学大学院生命科学研究部 代謝内科学分野
  • URL: http://www2.kuh.kumamoto-u.ac.jp/met/clinical/index.html
• [Remarks] 熊本大学大学院生命科学研究部 代謝内科学分野
  • URL: http://www2.kuh.kumamoto-u.ac.jp/met/
• [Patent(Industrial Property Rights)] 炎症及び過剰免疫を抑制する装置、並びに炎症及び過剰免疫を抑制するための方法 (2020)
  • Inventor(s): 甲斐広文, 首藤剛, メリーアンスイコ, 荒木栄一, 近藤龍也
  • Industrial Property Rights Holder: 甲斐広文, 首藤剛, メリーアンスイコ, 荒木栄一, 近藤龍也
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
  • Acquisition Date: 2020