Prevention of HBV recurrence by HBV vaccination based on SNP and allele of HLA class II

• Project/Area Number: 18K08542
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Kyushu University
• Principal Investigator: YOSHIZUMI Tomoharu 九州大学, 医学研究院, 准教授 (80363373)
• Co-Investigator(Kenkyū-buntansha): 間野 洋平 九州大学, 大学病院, 助教 (10792244) ; 副島 雄二 信州大学, 学術研究院医学系, 教授 (30325526) ; 戸島 剛男 九州大学, 大学病院, 助教 (40608965) ; 西田 奈央 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (50456109) ; 本村 貴志 九州大学, 医学研究院, 共同研究員 (50719507) ; 原田 昇 九州大学, 大学病院, 講師 (80419580) ; 池上 徹 九州大学, 大学病院, 講師 (80432938) ; 伊藤 心二 九州大学, 大学病院, 助教 (90382423) ; 吉屋 匠平 九州大学, 大学病院, 医員 (20717079)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: B型肝炎ウイルス / ワクチン / 生体肝移植 / HBVワクチン / 肝移植 / HLA / HLA-Class II

Outline of Final Research Achievements

Prevention of HBV recurrence after living donor liver transplantation (LDLT) was consisted of nucleotide analogue and Hepatitis B immunogloburin (HBIG). But, ideal prevention of HBV recurrence is HBV vaccination. We gave HBV vaccination for 36 LDLT patients. Among them, 19 patients were effective and 17 patients were ineffective. Donor gender (female), primary disease (other than liver cirrhosis due to HBV), SNP(HLA-DPA1 rs3077 TT and HLA-DPB1 rs9277535 AA) and alleles of HLA class II (HLA-DPB1 02:01,04:02m HLA-DRB1 08:03,04:05 and HLA-DRB1 no 09:01,15:02) were predictive factors of HBV vaccination effect after LDLT. javascript:onTransientSave()

Academic Significance and Societal Importance of the Research Achievements

HBV関連肝移植患者において、HLA-DPB1のSNP及びHLA-DPB1/DRB1のアリルがHBVワクチンの効果と関連することが明らかとなった。HBVワクチン有効例では、免疫抑制状態であるにもかかわらず、HBV再発の制御が不要となることも明らかとなった。HBVワクチン感受性の高い症例に優先的にワクチンを接種することで、全く新しい移植後HBV再発/再活性化制御法確立の可能性が得られた。

Research Products

• [Journal Article] Simultaneous splenectomy improves outcomes after adult living donor liver transplantation. (2021)
  • Author(s): Yoshizumi T, Itoh S, Shimokawa M, Inokuchi S, Harada N, Takeishi K, Mano Y, Yoshiya S, Kurihara T, Nagao Y, Ikegami T, Soejima Y, Mori M.
  • Journal Title: J Hepatol. Volume: 74(2) Issue: 2 Pages: 372-379
  • DOI: 10.1016/j.jhep.2020.08.017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Predictor of outcome after living donor liver transplantation for patients with hepatocellular carcinoma beyond the Japan criteria (2020)
  • Author(s): Yonemura Y, Yoshizumi T, Inokuchi S, Kosai-Fujimoto Y, Harada N, Itoh S, Toshima T, Takeishi K, Yoshiya S, Mori M.
  • Journal Title: Ann Gastroenterol Surg Volume: 4 Issue: 4 Pages: 413-421
  • DOI: 10.1002/ags3.12335
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Portal flow modulation in living donor liver transplantation: review with a focus on splenectomy. (2020)
  • Author(s): Yoshizumi T, Mori M.
  • Journal Title: Surgery Today Volume: 50 Issue: 1 Pages: 21-29
  • DOI: 10.1007/s00595-019-01881-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Impact of Osteopenia in Patients Who Underwent Living Donor Liver Transplantation for Hepatocellular Carcinoma. (2020)
  • Author(s): Toshima T, Yoshizumi T, Kosai-Fujimoto Y, Inokuchi S, Yoshiya S, Takeishi K, et al.
  • Journal Title: World J Surg. Volume: 44 Issue: 1 Pages: 258-267
  • DOI: 10.1007/s00268-019-05206-5
  • Peer Reviewed
• [Journal Article] Biliary Stricture: the Achilles heel of pediatric living donor liver transplantation. (2019)
  • Author(s): Yoshizumi T, Harada N, Mori M
  • Journal Title: Transplantation Volume: Feb 4 Issue: 9 Pages: 1758-1759
  • DOI: 10.1097/tp.0000000000002573
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] It is time to abandon the Milan criteria. (2019)
  • Author(s): Yoshizumi T, Shirabe K, Mori M
  • Journal Title: Hepatobiliary Surg Nutr. Volume: 8 Issue: 1 Pages: 56-58
  • DOI: 10.21037/hbsn.2018.10.08
  • Peer Reviewed / Int'l Joint Research
• [Presentation] HBIGフリーによる生体肝移植後HBV再活性化予防法の成績 (2020)
  • Author(s): 吉住 朋晴、池上 徹、森 正樹
  • Organizer: 第106回日本消化器病学会総会
• [Presentation] HBIGフリーによる生体肝移植後HBV再活性化予防法の成績 (2020)
  • Author(s): 吉住朋晴、池上 徹、原田 昇、伊藤心二、武石一樹、戸島剛男、吉屋匠平、 森 正樹
  • Organizer: 第56回日本肝臓学会総会
• [Presentation] Long term outcomes of ABO incompatible liver transplant. (2019)
  • Author(s): Yoshizumi T, Mori M.
  • Organizer: 5th CLBS symposium
  • Int'l Joint Research / Invited
• [Presentation] Surgery for Hepatocellular Carcinoma (2019)
  • Author(s): Yoshizumi T, Mori M.
  • Organizer: Indian Association of Surgical Gastroenterology Annual Conference
  • Int'l Joint Research / Invited
• [Presentation] 肝細胞癌合併B型肝硬変に対する生体肝移植の成績に関する検討と今後の展望 (2018)
  • Author(s): 吉住朋晴 他
  • Organizer: JDDW 2018
• [Presentation] Open Left Lateral Donor Hepatectomy (2018)
  • Author(s): Yoshizumi T
  • Organizer: 13th IHPBA World Congress
  • Int'l Joint Research / Invited