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Field experimental research using an infant stool color detection algorithm for early diagnosis of biliary atresia

Research Project

Project/Area Number 18K08575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionKochi University

Principal Investigator

Obatake Masayuki  高知大学, 医学部附属病院, 特任教授 (50336153)

Co-Investigator(Kenkyū-buntansha) 星野 絵里  立命館大学, 総合科学技術研究機構, 准教授 (50598521)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords人工知能 / 便色 / 早期発見 / 胆道閉鎖症 / 胆汁うっ滞性肝疾患 / アプリケーション / AI(人工知能) / 胆道閉鎖所 / AI / スクリーニング / 画像診断 / 胆汁鬱滞性肝疾患 / 新生児乳児検診
Outline of Final Research Achievements

The number of cases (mean birth weight, mean weeks of gestation) at the four facilities participating in this study was 2463, including facility A: 767 cases (2931 g, 38 weeks 6 days), facility B: 289 cases (3013 g, 39 weeks 1 day), facility C: 596 cases (2881 g, 38 weeks 2 days), and facility D: 811 cases (3066 g, 39 weeks 4 days). This corresponded to 71.5% of all births during the study period. The results were 96.59% "no abnormality", 0.14% "necessary observation,", and 3.29% "be careful". Surgical treatment was performed in 2 of the 84 cases judged to be "necessary observation" and "be careful", and the sensitivity and specificity for detecting liver disease requiring surgical treatment were 100% and 96.7%, respectively. This study was considered useful as a method for early detection of biliary atresia and biliary congestive disease.

Academic Significance and Societal Importance of the Research Achievements

胆道閉鎖症および胆汁うっ滞性肝疾患の早期発見のため母子手帳に添付されている便色カラーカードは簡便で安価なスクリーニング法であり、海外での使用も報告されている。しかし肉眼で児の便色と比較するため主観的判断による見逃しや診断遅れなどが問題となっている。本研究のAIによる判定は人間の目で認識・判断する必要が無く、プログラムが微細な色調変化を的確に診断することでより早期の疾患の発見が可能となり、便色カラーカードに替わる方法として期待される。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] 特集 周産期と最先端サイエンス 新生児領域 AIを応用した便色判定アプリケーションによる胆道閉鎖症早期発見の試み2022

    • Author(s)
      大畠 雅之、藤枝 悠希、林 邦好、星野 絵里
    • Journal Title

      周産期医学

      Volume: 52 Issue: 7 Pages: 1018-1022

    • DOI

      10.24479/peri.0000000249

    • ISSN
      0386-9881
    • Year and Date
      2022-07-10
    • Related Report
      2022 Annual Research Report
  • [Journal Article] Laparoscopic cholecystectomy for gallbladder torsion in a 3‐year‐old child2021

    • Author(s)
      Uemura Sunao、Maeda Hiromichi、Obatake Masayuki、Namikawa Tsutomu、Kitagawa Hiroyuki、Fujieda Yuki、Nishimoto Yuka、Morishita Yusuke、Fujieda Mikiya、Hanazaki Kazuhiro
    • Journal Title

      Acute Medicine & Surgery

      Volume: 8 Issue: 1

    • DOI

      10.1002/ams2.722

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] NEW STOOL COLOR SCREENING FOR BILIARY ATRESIA USING AI TECHNOLOGY2023

    • Author(s)
      Masayuiki Obatake, Yuki Fujieda
    • Organizer
      THe 24th European Pediatric Surgeons’ Association (EUPSA)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 便色判定ログラムを利用した胆道閉鎖症早期発見に対するフィールド実証研究2022

    • Author(s)
      大畠雅之
    • Organizer
      日本小児外科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] AIを応用した便色判定プログラムによる新生児・乳児胆汁うっ帯疾患早期発見2022

    • Author(s)
      大畠雅之、藤枝悠希、林邦好、星野絵里
    • Organizer
      日本胆道閉鎖症研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] New Stool Color Screening for Biliary Atresia Using AI Technology2022

    • Author(s)
      Masayuki Obatake, Yuki Fujieda,
    • Organizer
      The 26th Congress of The Asian Association of Pediatric Surgeons
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AIテクノロジーを応用した便色判定アプリケーションによる胆道閉鎖症早期発見の試み2020

    • Author(s)
      大畠雅之
    • Organizer
      日本小児外科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] AIテクノロジーを応用した新生児・乳児便色評価の試みついて2019

    • Author(s)
      大畠雅之、花﨑和弘、星野絵理
    • Organizer
      第46回日本胆道閉鎖症研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胆道閉鎖症に対する尿中硫酸抱合型胆汁酸測定の検討2019

    • Author(s)
      大畠雅之、田浦康明、山根祐介、吉田拓郎、花﨑和弘
    • Organizer
      第46回日本胆道閉鎖症研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] FEASIBILITY OF BILIARY ATRESIA SCREENING USING NEW AI TECHNOLOBY-APPLIED STOOL COLOR DISCREMINATION SYSTEM2019

    • Author(s)
      Masayuki Obatake
    • Organizer
      European Paediatric Surgeons' Association
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] Introduction to Biliary Atresia2021

    • Author(s)
      Masayuki Obatake
    • Publisher
      Springer
    • Related Report
      2021 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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