Consideration of effectiveness of intra-abdominal hyperthermia chemotherapy devised from abscopal effect
Project/Area Number |
18K08592
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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Research Institution | Mie University |
Principal Investigator |
Miki Chikao 三重大学, 医学系研究科, 客員教授 (50242962)
|
Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学系研究科, 教授 (00422824)
奥川 喜永 三重大学, 医学部附属病院, 講師 (30555545)
藤川 裕之 三重大学, 医学部附属病院, 助教 (40616091)
安田 裕美 三重大学, 医学部附属病院, 助教 (60586767)
楠 正人 三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
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Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 胃癌 / アブスコパル効果 / 腹膜播種 / 免疫チェックポイント阻害剤 / 腹腔内温熱化学療法 |
Outline of Final Research Achievements |
It was difficult to elucidate for abscopal effect with intra-abdominal hyperthermia chemotherapy, because we could not make the mouse model with gastric cancer peritoneal metastases. High L1CAM expression was significantly associated with peritoneal metastasis. Gastric cancer tissue PD-L1 expression was significantly higher in the GC patients with and peritoneal metastasis. Additionally, CLR size correlated with patient nutritional status and prognosis and may be helpful in identifying high-risk populations of GC patients.
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Academic Significance and Societal Importance of the Research Achievements |
本研究結果を用いることで、胃癌患者における新たな予後マーカーの可能性が示唆された。腫瘍側と宿主側の両方向性にAbscopal効果の機序解明とAbscopal効果予測マーカーの確立につながると考える。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Lymphocyte-C-reactive Protein Ratio as Promising New Marker for Predicting Surgical and Oncological Outcomes in Colorectal Cancer.2019
Author(s)
Okugawa Y, Toiyama Y, Yamamoto A, Shigemori T, Ide S, Kitajima T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Yokoe T, Saigusa S, Tanaka K, Shirai Y, Kobayashi M, Ohi M, Araki T, McMillan DC, Miki C, Goel A, Kusunoki M
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Journal Title
Ann Surg. 2019 Feb 16.
Volume: Feb
Issue: 2
Pages: 16-16
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression.2019
Author(s)
Shigemori T, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Narumi A, Ichikawa T, Ide S, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M.
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Journal Title
Ann Surg Oncol.
Volume: 26
Issue: 3
Pages: 876-883
DOI
Related Report
Peer Reviewed / Open Access
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