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Elucidation of the mechanism of metastasis formation using the engraftment ability of free cancer cells and establishment of new indications for HIPEC therapy

Research Project

Project/Area Number 18K08674
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionMie University

Principal Investigator

Yasuda Hiromi  三重大学, 医学部附属病院, 助教 (60586767)

Co-Investigator(Kenkyū-buntansha) 問山 裕二  三重大学, 医学系研究科, 教授 (00422824)
奥川 喜永  三重大学, 医学部附属病院, 講師 (30555545)
吉山 繁幸  三重大学, 医学系研究科, リサーチアソシエイト (60444436)
大井 正貴  三重大学, 医学部附属病院, 准教授 (40418752)
楠 正人  三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胃癌 / 遊離癌細胞 / 腹膜播種 / 浮遊癌細胞 / エピゲノム / バイオマーカー
Outline of Final Research Achievements

We performed a systematic biomarker discovery by analyzing miRNA expression profiles in primary tumors from GC patients with and without PM. Among 5 miRNA, 3 of which (miR-30a-5p, -659-3p, and -3917) were significantly overexpressed in the primary tumors from PM-positive patients in the testing cohort, and distinguished patients with the value of AUC of 0.82. The efficacy of the combination miRNA signature was subsequently validated in an independent validation cohort (AUC = 0.74). Finally, our miRNA signature when combined together with the macroscopic Borrmann's type score offered a much superior diagnostic in all 3 cohorts (AUC = 0.87, 0.76, and 0.79, respectively).

Academic Significance and Societal Importance of the Research Achievements

網羅的解析ならびに生物統計学的手法で同定した胃癌腹膜播種症例で特異的に異常発現するmiRNAパネルが胃癌腹膜播種同定において有用なバイオマーカーとなりうる可能性を証明した。今後はさらに該当する症例の腫瘍組織/血液/腹水/術中洗浄液を適切にサンプリング、保管管理し、miRNAパネルが胃癌個別化治療の効果予測因子として有用か否かを検証していく方向であり、今回の研究で得られた成果は臨床償却の上で大きな意義を成すと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (10 results)

  • [Journal Article] Clinical significance of advanced lung cancer inflammation index, a nutritional and inflammation index, in gastric cancer patients after surgical resection: A propensity score matching analysis2021

    • Author(s)
      Yin C, Toiyama Y, Okugawa Y, Omura Y, Kusunoki Y, Kusunoki K, Imaoka Y, Yasuda H, Ohi M, Kusunoki M
    • Journal Title

      Clin Nutr.

      Volume: 40 Issue: 3 Pages: 1130-1136

    • DOI

      10.1016/j.clnu.2020.07.018

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lymphocyte-to-C-reactive protein ratio and score are clinically feasible nutrition-inflammation markers of outcome in patients with gastric cancer2020

    • Author(s)
      Okugawa Yoshinaga、Toiyama Yuji、Yamamoto Akira、Shigemori Tsunehiko、Ichikawa Takashi、Yin Chengzeng、Suzuki Akihiro、Fujikawa Hiroyuki、Yasuda Hiromi、Hiro Junichiro、Yoshiyama Shigeyuki、Ohi Masaki、Araki Toshimitsu、McMillan Donald C.、Kusunoki Masato
    • Journal Title

      Clinical Nutrition

      Volume: 39 Issue: 4 Pages: 1209-1217

    • DOI

      10.1016/j.clnu.2019.05.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modified neutrophil-platelet score as a promising marker for stratified surgical and oncological outcomes of patients with gastric cancer.2020

    • Author(s)
      Okugawa Y, Toiyama Y, Yamamoto A, Omura Y, Kusunoki K, Yin C, Ide S, Kitajima T, Koike Y, Fujikawa H, Yasuda H, Okita Y, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M
    • Journal Title

      Surg Today

      Volume: 50(3) Issue: 3 Pages: 223-231

    • DOI

      10.1007/s00595-019-01873-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crohn's-Like Lymphoid Reaction is Associated with Oncological Prognosis and Nutritional Status in Patients with Pathological Stage II/III Gastric Cancer.2020

    • Author(s)
      Omura Y, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Kusunoki K, Kusunoki Y, Shigemori T, Ide S, Kitajima T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Kusunoki M.
    • Journal Title

      Ann Surg Oncol

      Volume: 27 Issue: 1 Pages: 259-267

    • DOI

      10.1245/s10434-019-07709-w

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer2019

    • Author(s)
      Ichikawa Takashi、Okugawa Yoshinaga、Toiyama Yuji、Tanaka Koji、Yin Chengzeng、Kitajima Takahito、Kondo Satoru、Shimura Tadanobu、Ohi Masaki、Araki Toshimitsu、Kusunoki Masato
    • Journal Title

      British Journal of Cancer

      Volume: 121 Issue: 12 Pages: 1058-1068

    • DOI

      10.1038/s41416-019-0646-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomewide Expression Profiling Identifies a Novel miRNA-Based Signature for the Detection of Peritoneal Metastasis in Patients With Gastric Cancer2019

    • Author(s)
      Shimura Tadanobu、Toden Shusuke、Kandimalla Raju、Toiyama Yuji、Okugawa Yoshinaga、Kanda Mitsuro、Baba Hideo、Kodera Yasuhiro、Kusunoki Masato、Goel Ajay
    • Journal Title

      Annals of Surgery

      Volume: - Issue: 5 Pages: 1-1

    • DOI

      10.1097/sla.0000000000003647

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression.2019

    • Author(s)
      Shigemori T, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Narumi A, Ichikawa T, Ide S, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M.
    • Journal Title

      Ann Surg Oncol.

      Volume: 26 Issue: 3 Pages: 876-883

    • DOI

      10.1245/s10434-018-07112-x

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer2018

    • Author(s)
      Okugawa Yoshinaga、Toiyama Yuji、Shigeyasu Kunitoshi、Yamamoto Akira、Shigemori Tsunehiko、Yin Chengzeng、Ichikawa Takashi、Yasuda Hiromi、Fujikawa Hiroyuki、Yoshiyama Shigeyuki、Hiro Junichiro、Ohi Masaki、Araki Toshimitsu、Kusunoki Masato、Goel Ajay
    • Journal Title

      Journal of Translational Medicine

      Volume: 16 Issue: 1 Pages: 366-366

    • DOI

      10.1186/s12967-018-1740-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 胃癌腹膜播種同定に関連するmicroRNA signatureの臨床的意義2020

    • Author(s)
      志村 匡信, 問山 裕二, 奥川 喜永, 安田 裕美, 藤川 裕之, 横江 毅, 廣 純一郎, 大井 正貴, 泉 大輔, 馬場 秀夫, 楠 正人, Ajay Goel
    • Organizer
      第120回日本外科学会定期学術
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胃癌におけるRNAメチル化酵素METTL3発現の臨床的意義2020

    • Author(s)
      奥川 喜永, 問山 裕二, 北嶋 貴仁, 志村 匡信, 横江 毅, 廣 純一郎, 楠 正人
    • Organizer
      第79回日本癌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胃癌患者における16種類のm6A RNA修飾制御因子発現と予後への意義2020

    • Author(s)
      志村 匡信, 問山 裕二, 奥川 喜永, 今岡 裕基, 安田 裕美, 横江 毅, 廣 純一郎, 大井 正貴, Goel Ajay, 楠 正人
    • Organizer
      第75回日本消化器外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胃癌におけるEMAST,MSIの臨床病理学的検討2020

    • Author(s)
      北嶋貴仁、市川崇、今岡裕基、安田裕美、藤川裕之、奥川喜永、横江毅、問山裕二、大井正貴、楠正人
    • Organizer
      第75回日本消化器外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Stage Ⅱ,Ⅲ胃癌に対するGustave Roussy Immune Scoreの意義2020

    • Author(s)
      横江 毅、市川 崇、今岡裕基、安田裕美、奥川喜永、大北喜基、問山裕二、大井正貴、楠 正人
    • Organizer
      第92回胃癌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Stage II,III胃癌患者に対する術後1年以内の早期再発に関連する因子の検討2020

    • Author(s)
      横江 毅、市川 崇、今岡裕基、安田裕美、藤川裕之、奥川喜永、大北喜基、大井正貴、問山裕二
    • Organizer
      第75回日本消化器外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胃上部癌に対する術式選択の取り組み~センチネルリンパ節の分布からみた検討~2019

    • Author(s)
      大井正貴、吉山繁幸、安田裕美、市川 崇、浦谷 亮、重盛恒彦、藤川裕之、大北喜基、奥川喜永、廣 純一郎、問山裕二、荒木俊光 、楠 正人
    • Organizer
      第119回日本外科学会定期学術集会、大阪
    • Related Report
      2019 Research-status Report
  • [Presentation] RNAメチル化制御遺伝子パネルの胃癌患者における予後・再発マーカーとしての意義2019

    • Author(s)
      志村匡信、問山裕二、奥川喜永、 Raju Kandimalla、 今岡裕基、北嶋貴仁、安田裕美、横江 毅、大井正貴、荒木俊光、楠 正人、Ajay Goel
    • Organizer
      第57回日本癌治療学会学術集会、福岡
    • Related Report
      2019 Research-status Report
  • [Presentation] StageⅡ/Ⅲ胃癌におけるCrohn’s-Like Lymphoid Reactionの腫瘍学的予後と栄養指標に関する検討.2019

    • Author(s)
      大村悠介、問山裕二、奥川喜永、楠 蔵人、尹 成増、山本 晃、市川 崇、重盛恒彦、井出正造、北嶋貴仁、安田裕美、藤川裕之、廣 純一郎、吉山繁幸、大井正貴、荒木俊光、楠 正人
    • Organizer
      第119回日本外科学会定期学術集会、大阪
    • Related Report
      2019 Research-status Report
  • [Presentation] 食道癌術後肺炎のリスク因子についての検討2019

    • Author(s)
      安田裕美、浦谷 亮、重盛恒彦、吉山繁幸、大井正貴、北嶋貴仁、藤川裕之、奥川喜永、大北喜基、廣 純一郎、問山裕二、荒木俊光、楠 正人
    • Organizer
      第119回日本外科学会定期学術集会、大阪
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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