Elucidation of the mechanism of metastasis formation using the engraftment ability of free cancer cells and establishment of new indications for HIPEC therapy
Project/Area Number |
18K08674
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Mie University |
Principal Investigator |
Yasuda Hiromi 三重大学, 医学部附属病院, 助教 (60586767)
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Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学系研究科, 教授 (00422824)
奥川 喜永 三重大学, 医学部附属病院, 講師 (30555545)
吉山 繁幸 三重大学, 医学系研究科, リサーチアソシエイト (60444436)
大井 正貴 三重大学, 医学部附属病院, 准教授 (40418752)
楠 正人 三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 胃癌 / 遊離癌細胞 / 腹膜播種 / 浮遊癌細胞 / エピゲノム / バイオマーカー |
Outline of Final Research Achievements |
We performed a systematic biomarker discovery by analyzing miRNA expression profiles in primary tumors from GC patients with and without PM. Among 5 miRNA, 3 of which (miR-30a-5p, -659-3p, and -3917) were significantly overexpressed in the primary tumors from PM-positive patients in the testing cohort, and distinguished patients with the value of AUC of 0.82. The efficacy of the combination miRNA signature was subsequently validated in an independent validation cohort (AUC = 0.74). Finally, our miRNA signature when combined together with the macroscopic Borrmann's type score offered a much superior diagnostic in all 3 cohorts (AUC = 0.87, 0.76, and 0.79, respectively).
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Academic Significance and Societal Importance of the Research Achievements |
網羅的解析ならびに生物統計学的手法で同定した胃癌腹膜播種症例で特異的に異常発現するmiRNAパネルが胃癌腹膜播種同定において有用なバイオマーカーとなりうる可能性を証明した。今後はさらに該当する症例の腫瘍組織/血液/腹水/術中洗浄液を適切にサンプリング、保管管理し、miRNAパネルが胃癌個別化治療の効果予測因子として有用か否かを検証していく方向であり、今回の研究で得られた成果は臨床償却の上で大きな意義を成すと考える。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Clinical significance of advanced lung cancer inflammation index, a nutritional and inflammation index, in gastric cancer patients after surgical resection: A propensity score matching analysis2021
Author(s)
Yin C, Toiyama Y, Okugawa Y, Omura Y, Kusunoki Y, Kusunoki K, Imaoka Y, Yasuda H, Ohi M, Kusunoki M
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Journal Title
Clin Nutr.
Volume: 40
Issue: 3
Pages: 1130-1136
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modified neutrophil-platelet score as a promising marker for stratified surgical and oncological outcomes of patients with gastric cancer.2020
Author(s)
Okugawa Y, Toiyama Y, Yamamoto A, Omura Y, Kusunoki K, Yin C, Ide S, Kitajima T, Koike Y, Fujikawa H, Yasuda H, Okita Y, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M
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Journal Title
Surg Today
Volume: 50(3)
Issue: 3
Pages: 223-231
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Crohn's-Like Lymphoid Reaction is Associated with Oncological Prognosis and Nutritional Status in Patients with Pathological Stage II/III Gastric Cancer.2020
Author(s)
Omura Y, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Kusunoki K, Kusunoki Y, Shigemori T, Ide S, Kitajima T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Kusunoki M.
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Journal Title
Ann Surg Oncol
Volume: 27
Issue: 1
Pages: 259-267
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression.2019
Author(s)
Shigemori T, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Narumi A, Ichikawa T, Ide S, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M.
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Journal Title
Ann Surg Oncol.
Volume: 26
Issue: 3
Pages: 876-883
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 胃癌腹膜播種同定に関連するmicroRNA signatureの臨床的意義2020
Author(s)
志村 匡信, 問山 裕二, 奥川 喜永, 安田 裕美, 藤川 裕之, 横江 毅, 廣 純一郎, 大井 正貴, 泉 大輔, 馬場 秀夫, 楠 正人, Ajay Goel
Organizer
第120回日本外科学会定期学術
Related Report
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