• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clinical significance of defective DNA double-strand break repair pathway in gastric cancer

Research Project

Project/Area Number 18K08698
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionNiigata University

Principal Investigator

Katada Tomohiro  新潟大学, 医歯学総合研究科, 客員研究員 (20815782)

Co-Investigator(Kenkyū-buntansha) 若井 俊文  新潟大学, 医歯学系, 教授 (50372470)
市川 寛  新潟大学, 医歯学系, 助教 (50721875)
島田 能史  新潟大学, 医歯学系, 講師 (20706460)
永橋 昌幸  新潟大学, 医歯学総合病院, 研究准教授 (30743918)
羽入 隆晃  新潟大学, 医歯学総合病院, 助教 (50719705)
小杉 伸一  新潟大学, 医歯学総合病院, 特任教授 (90401736)
廣瀬 雄己  新潟大学, 医歯学総合病院, 特任助教 (10737365)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords胃癌 / 相同組換え修復 / がん遺伝子パネル検査 / 白金系抗癌剤 / homologous recombination / 癌遺伝子パネル / mutational signature / DNA二重鎖切断 / 化学療法
Outline of Final Research Achievements

Homologous recombination (HR) deficiency due to the genetic alteration of HR genes contributes to a more favorable response to platinum-based chemotherapy in ovarian and breast cancers. However, the association between HR deficiency and the treatment response to platinum-based chemotherapy has not been elucidated in gastric cancer (GC).
We explored the clinical significance of HR deficiency detected by cancer gene panel testing in association with platinum-based chemotherapy for unresectable metastatic GC.
The somatic alterations of HR genes were identified in 23% of patients with unresectable metastatic GC. HR deficiency was associated with significantly better response to platinum-based chemotherapy and favorable outcomes after treatment for unresectable metastatic GC. The clinical utility of assessing for HR deficiency in platinum-based chemotherapy is worth exploring in further large-scale validation studies to improve patient outcomes associated with GC.

Academic Significance and Societal Importance of the Research Achievements

本研究では現在保険診療として臨床使用されているがん遺伝子パネル検査による遺伝子解析結果を用い、DNA損傷修復機構に関わる遺伝子異常が胃癌の化学療法における一次治療や術前治療で用いられる白金系抗癌剤の治療効果に関与していることを明らかにした。現在のがん遺伝子パネル検査は標準治療以降の治療薬を探索するために用いられている。本研究の結果は、がん遺伝子パネル検査は胃癌の一次治療の選択や術前治療に効果の高い症例を選択することにも役立つ可能性を示唆している。本研究から、今後のがん遺伝子パネル検査の適用拡大や胃癌治療の発展のために重要な知見を得ることができた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2019

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Genomic alteration spectrum and future direction of targeted therapy for gastric cancer2019

    • Author(s)
      Hiroshi Ichikawa, Hiroshi Yabusaki, Takaaki Hanyu, Yoshifumi Shimada, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Satoru Nakagawa, Hitoshi Kameyama, Toshifumi Wakai
    • Organizer
      第74回日本消化器外科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Defective Homologous Recombination in Platinum-based Chemotherapy for Gastric Cancer2019

    • Author(s)
      T. Katada, H. Ichikawa, Y. Hirose, M. Nagahashi, Y. Shimada, T. Hanyu, T. Ishikawa, Y. Kano, Y. Muneoka, J. Sakata, T. Kobayashi, H. Kameyama, T. Wakai
    • Organizer
      14th Annual Academic Surgical Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi