| Project/Area Number |
18K08713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Nagoya City University |
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Principal Investigator |
Hayashi Yuichi 名古屋市立大学, 医薬学総合研究院(医学), 助教 (60811726)
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| Co-Investigator(Kenkyū-buntansha) |
松尾 洋一 名古屋市立大学, 医薬学総合研究院(医学), 教授 (40381800)
高橋 広城 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (30381792)
坪井 謙 名古屋市立大学, 医薬学総合研究院(医学), 助教 (80592500)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | レゾルビン / オメガ3不飽和脂肪酸 / 血管新生 / NF-κB / 膵癌 / 分子標的薬剤 |
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| Outline of Final Research Achievements |
Since the transcription factor NF-κB signaling is involved in the effects of omega-3 unsaturated fatty acids, we conducted experiments using resolvin, a metabolite of EPA and DHA, which are representative omega-3 unsaturated fatty acids. VEGF was targeted as an angiogenic factor downstream of NF-κB, and the amount of VEGF produced by resolvin administration was examined. The results showed that VEGF production was inhibited in a resolvin concentration-dependent manner, but the reproducibility of the results showed that the results differed greatly depending on the concentration of DMSO dissolved in resolvin. These results indicate that resolvin is unlikely to have antitumor effects on pancreatic cancer among omega-3 unsaturated fatty acids.
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| Academic Significance and Societal Importance of the Research Achievements |
既報では，日本での大規模な疫学調査により，魚由来のオメガ3不飽和脂肪酸を多く摂取している群と摂取量が少ない群と比較し，膵癌の発症リスクが0.7倍に減ることが報告されている．今回，オメガ3不飽和脂肪酸の代謝産物レゾルビンでは，その抑制効果および原因究明には至らなかったが，オメガ3不飽和脂肪酸が膵癌抑制に寄与する可能性はあり，今後の研究が望まれる．
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