Effects of perivascular tissue on endothelial function of internal thoracic artery in CABG

• Project/Area Number: 18K08752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Kanazawa University
• Principal Investigator: Iino Kenji 金沢大学, 附属病院, 講師 (60595453)
• Co-Investigator(Kenkyū-buntansha): 竹村 博文 金沢大学, 医学系, 教授 (20242521) ; 多久和 陽 金沢大学, 医学系, 協力研究員 (60171592)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 冠動脈バイパス術 / 血管内皮 / 内皮機能 / 一酸化窒素

Outline of Final Research Achievements

We investigated whether perivascular tissue of internal thoracic artery affects the endothelial function in patients with CABG. We measured the nitric oxide, CGMP, endothelin derived by endothelium using immunoassay by comparing harvesting techniques (skeletonization vs pedicle). The plasma concentration of cGMP in pedicle group tends to be higher and the concentration of endothelin in pedicle group was lower than ones in skeletonization group. Perivascular tissue may affect the production of cGMP and ET which leads to long term graft patency.

Academic Significance and Societal Importance of the Research Achievements

Pedicle法による内胸動脈採取法は内皮機能の温存に優れている可能性が示唆された。グラフトの内皮機能温存という課題を解決し、より良い採取法が明らかととなり、内胸動脈の長期開存率、CABGの長期成績をさらに向上することができる。