Influence of anesthetics on host immunity through cancer microenvironment
| Project/Area Number |
18K08872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 信夫 朝日大学, 歯学部, 教授 (40202072)
智原 栄一 朝日大学, 保健医療学部, 教授 (80244581)
村松 泰徳 朝日大学, 歯学部, 教授 (30247556)
高山 英次 朝日大学, 歯学部, 准教授 (70533446)
川木 晴美 朝日大学, 歯学部, 教授 (70513670)
梅村 直己 朝日大学, 歯学部, 講師 (80609107)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ミダゾラム / 抗腫瘍免疫 / 腫瘍組織内微小環境 / サイトカイン / 口腔扁平上皮癌 / 免疫抑制 / インターロイキン-10 / GABA受容体 / インターロイキン10 / インターフェロンγ / 可逆性 / IL-10 / IFN-γ / 癌微小環境 / 間質細胞 / IFN－γ / IL-2 / 遺伝子発現 / ガン組織微小環境 / 麻酔薬 / 癌組織微小環境 |
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| Outline of Final Research Achievements |
The effects of "sedatives and anesthetics" on the tumor microenvironment were examined using a mouse system, and the following effects have been found in low dose (5 μg/ml) midazolam.
(1) Midazolam inhibited the interleukin (IL)-10 producing ability of mouse splenocytes at the transcriptional level while preserving the interferon (IFN)-γ producing ability, (2) it eliminated the inhibitory effect by stromal cells (10T1/2) on the IFN-γ producing ability of splenocytes, (3) it reduced an immunosuppressive humoral factor (IL-a) from Sq-1979-1, (4) It was clarified that splenocytes isolated from tumor-bearing mice receiving repeated administration of midazolam tended to be resistant to the action of 10 T1/2. Such effects were not observed with other drugs used and were specific for midazolam.
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| Academic Significance and Societal Importance of the Research Achievements |
日本は超高齢社会を迎え、かつては手術適応にならなかったような、多くの合併症を抱える患者や高齢者なども、手術適応と判断される時代となった。がん患者の周術期管理にかんしても同様であり、良好な予後のための鎮静・麻酔薬の選択方法の確立が急務となっている。
本研究では、動物を用いた実験ではあるが、ミダゾラムが免疫担当細胞のみならず、間質細胞や口腔扁平上皮がん細胞にも作用してTh1型免疫反応を回復させる効果を持ち、がん組織内の免疫抑制環境の改善に寄与できる可能性を指摘できた。これらの結果は、周術期の薬剤選択を考える際の有用な基礎的資料であると考える。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Suppression effect of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.2018
Author(s)
Masuda J, Takayama E, Ichinohe T, Strober W, Mizuno-Kamiya M, Ikawa T, Kitani A, Kawaki H, Fuss IJ, Kawamoto H, Seno A, Vaidyanath A, UmemuraN, Mizutani A, Kasai T, Honjo Y, Satoh A, Murakami H, Katsura Y, Kondoh N, Seno M
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Journal Title
Exp Ther Med
Volume: 16
Pages: 4277-4282
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Enhanced production of IL-2 from anti CD3-stimulated mouse spleen cells by Artepillin C, a major component of Brazilian green propolis.2022
Author(s)
Nobuo K, Mizuno-Kamiya M, Tsuruta H, Takahashi M, Ikeno K, Ueno K, Umemura N, Takayama E, Kawaki H, Nakamura G, Nikaido T and Muramatsu Y
Organizer
Annual Meeting 2022, American Association for Cancer Research (New Orleans Web参加
Related Report
Int'l Joint Research
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[Presentation] Augmented secretion of IL-1a from mouse oral squamous cell carcinoma (OSCC) cells caused by the serum deprivation and hypoxia promotes immune-suppressive activity of mesenchymal stromal cells.2021
Author(s)
Kondoh N, Matsunami A, Mizuno-Kamiya M, Umemura N, Takayama E, Kawaki H, Ueno K, Morimoto-Ito H, Muramatsu Y, Sumitomo S.
Organizer
Annual Meeting 2021, American Association for Cancer Research(Virtual)
Related Report
Int'l Joint Research
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