Impact of acute hemodynamic changes on cognition in elderly patients with subarachnoid hemorrhage

• Project/Area Number: 18K08880
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Akita Cerebrospinal and Cardiovascular Center (2022); Tohoku University (2018-2021)
• Principal Investigator: Mutoh Tatsushi 秋田県立循環器・脳脊髄センター(研究所), 脳卒中治療学研究部, 研究部長 (80462472)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: くも膜下出血 / 脳循環動態 / 心肺合併症 / 高齢者

Outline of Final Research Achievements

Early brain injury (EBI) is closely linked to the development of delayed cerebral ischemia and poor outcomes after aneurysmal subarachnoid hemorrhage (SAH). This in vivo study aimed to evaluate the hemodynamic effect induced by SAH on congitive dunction, using a mouse model of SAH created by filament perforation method. We found post-event treatment with several drugs (e.g.,neurotropin) could be protective against EBI, lowering the incidence of ischemia and improving some motor and neurocognitive functions after SAH.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、高齢者におけるSAHの超急性期における脳循環動態に着目した病態の解明と、予後改善に向けた有効な神経集中治療法の確立である。こうした老化に伴う病態が、SAH後のEBIや予後に及ぼす影響については未だ明らかにされておらず、高齢者SAHにおける治療後の機能回復の戦略を立てる上でも学術的に有益である。神経集中治療の観点から、認知機能・手段的生活機能を最終予後に見据えた研究結果は、高齢者におけるくも膜下出血患者の予後改善と治療費の軽減に直結する点においても、意義のある研究と考えられた。

Research Products

• [Journal Article] Post-Event Application of Neurotropin Protects against Ischemic Insult toward Better Outcomes in a Murine Model of Subarachnoid Hemorrhage (2021)
  • Author(s): Tatsushi Mutoh, Shuzo Yamamoto, Takahiro Moriya
  • Journal Title: Biomedicines Volume: 9 Issue: 6 Pages: 664-664
  • DOI: 10.3390/biomedicines9060664
  • Peer Reviewed / Open Access
• [Journal Article] Non‐invasive three‐dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage (2019)
  • Author(s): Yamamoto Shuzo、Mutoh Tatsushi、Sasaki Kazumasu、Mutoh Tomoko、Tatewaki Yasuko、Taki Yasuyuki
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: 46 Issue: 1 Pages: 99-102
  • DOI: 10.1111/1440-1681.13035
  • Peer Reviewed
• [Journal Article] Central action of rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage (2019)
  • Author(s): Yamamoto Shuzo、Mutoh Tatsushi、Sasaki Kazumasu、Mutoh Tomoko、Taki Yasuyuki
  • Journal Title: Brain Research Bulletin Volume: 144 Pages: 85-91
  • DOI: 10.1016/j.brainresbull.2018.11.015
  • Peer Reviewed
• [Journal Article] Performance of Electrical Velocimetry for Noninvasive Cardiac Output Measurements in Perioperative Patients After Subarachnoid Hemorrhage (2019)
  • Author(s): Mutoh Tatsushi、Sasaki Kazumasu、Yamamoto Shuzo、Yasui Nobuyuki、Ishikawa Tatsuya、Taki Yasuyuki
  • Journal Title: Journal of Neurosurgical Anesthesiology Volume: 31 Issue: 4 Pages: 422-427
  • DOI: 10.1097/ana.0000000000000519
  • Peer Reviewed
• [Presentation] くも膜下出血の神経原性肺水腫における血行動態と予後の検証 (2022)
  • Author(s): 武藤達士、師井淳太、佐々木一益、西野京子、石川達哉
  • Organizer: 日本脳神経外科学会 第81回学術総会
• [Presentation] 超音波を用いた最先端マルチモダリティイメージングシステム: マウスくも膜下出血モデルを用いた脳血流評価法について (2019)
  • Author(s): 武藤達士
  • Organizer: プライムテック・ワークショップ (東京・東京大学農学部) 2019年8月6日
  • Invited