| Project/Area Number |
18K08907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Tohoku University |
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Principal Investigator |
Saito Koji 東北大学, 大学病院, 准教授 (10359515)
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| Co-Investigator(Kenkyū-buntansha) |
山田 充啓 東北大学, 大学病院, 講師 (00396483)
武井 祐介 東北大学, 大学病院, 助教 (80822890)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロパーティクル / 敗血症 / 内皮傷害 / 血管透過性 / 血管内皮傷害 / 細胞外小胞 / 内皮微小粒子 |
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| Outline of Final Research Achievements |
Inflammatory stimulation to human umbilical vein endothelial cells (HUVECs) increased EMPs in a concentration-dependent manner. The circulating EMPs in patients with sepsis were significantly increased compared to non-septic patients, reflecting vascular endothelial injury. In addition, PECAM + EMPs and VE-cadherin + EMPs were significantly increased in septic shock patients compared to septic patients. When vascular permeability is changed to HUVECs by permeability modifying agents, PECAM + EMPs and VE-cadherin + EMPs were consistent with changes in vascular permeability and their release was altered, so that PECAM + EMPs and VE-cadherin + EMPs might be novel indicators of vascular permeability in sepsis.
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| Academic Significance and Societal Importance of the Research Achievements |
敗血症において血管内皮傷害は、病態形成に積極的に関与し、かつ血管内皮傷害は臓器傷害の主因となる。本課題により、内皮由来微小粒子（EMPs）は敗血症の血管内皮傷害マーカーとなり得ることをが示された。特にPECAM+EMPsやVE-cadherin+EMPsは、敗血症での血管透過性亢進の指標にもなり得るもので、今後の敗血症の新たな病態マーカーとなり得るものである。
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