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Elucidation of control mechanism of Survivin expression by extracellular exosome and its application to therapy / diagnosis

Research Project

Project/Area Number 18K09006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionTokyo Women's Medical University

Principal Investigator

Saito Taiichi  東京女子医科大学, 医学部, 講師 (40457247)

Co-Investigator(Kenkyū-buntansha) 岡本 沙織  東京女子医科大学, 医学部, 助教 (20746763)
濱 聖司  広島大学, 医系科学研究科(医), 研究員 (40397980)
村垣 善浩  東京女子医科大学, 医学部, 客員教授 (70210028)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsSurvivin / Nestin / Glioma / 血清濃度 / バイオマーカー / Vimentin / エクソソーム / 悪性グリオーマ
Outline of Final Research Achievements

We measured and compared nestin concentrations in the sera of glioma cases (WHO grade 2-4) and healthy adult volunteers using the ELISA method. Preoperative serum nestin levels in patients with grade 4 malignant glioma averaged 1.04 ng/ml (0.0-10.0) compared with 0.15 ng/ml (0-0.90) in healthy adult volunteers, which was statistically significant (p < 0.05). In the ROC analysis that discriminates grade 4 malignant glioma cases from healthy adult volunteers based on serum nestin concentration, a high detection rate of AUC = 0.85 was possible with a cutoff value of 0.63 ng/ml (p<0.0001).

Academic Significance and Societal Importance of the Research Achievements

本研究の検討では、血清nestin濃度がgrade4のグリオーマ患者と健常成人ボランティアとの鑑別に有用であることが示され、血清中nestinのバイオマーカーとしての意義の解明に有用な結果を得ることができた。今後の検討で血清中nestin濃度測定が、悪性グリオーマ患者の術前診断、あるいは治療中の効果判定に用いることが可能となれば、悪性グリオーマの早期発見、病状の判定に有用であり、悪性グリオーマの治療成績向上において社会的意義があるものと考えている。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (25 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (17 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results)

  • [Journal Article] 【神経解剖を理解した脳腫瘍手術 戦略と合併症対応】脳腫瘍手術戦略 髄内腫瘍(グリオーマ)2022

    • Author(s)
      齋藤太一
    • Journal Title

      脳神経外科速報

      Volume: 32 Pages: 326-332

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring Cortico-cortical Evoked Potentials Using Only Two 6-strand Strip Electrodes for Gliomas Extending to the Dominant Side of Frontal Operculum During One-step Tumor Removal Surgery2022

    • Author(s)
      Saito T, Muragaki Y, Tamura M, Maruyama T, Nitta M, Tsuzuki S, Fukui A, Koriyama S, Kawamata T
    • Journal Title

      World Neurosurg.

      Volume: 165 Pages: e732-e742

    • DOI

      10.1016/j.wneu.2022.06.141

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The high incidence and risk factors of levetiracetam and lacosamide-related skin rashes in glioma patients2022

    • Author(s)
      Onodera M, Saito T, Fukui A, Nitta M, Tsuzuki S, Koriyama S, Masamune K, Kawamata T, Muragaki Y
    • Journal Title

      Clin Neurol Neurosurg

      Volume: Epub

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal thickening of the maxillary sinus is frequently associated with diffuse glioma patients and correlates with poor survival prognosis of GBM patients: comparative analysis to meningioma patients2021

    • Author(s)
      Saito T, Muragaki Y, Maruyama T, Abe K, Komori T, Amano K, Eguchi S, Nitta M, Tsuzuki S, Fukui A, Kawamata T.
    • Journal Title

      Neurosurgical review

      Volume: 44 Issue: 6 Pages: 3249-3258

    • DOI

      10.1007/s10143-021-01490-9

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Awake craniotomy with transcortical motor evoked potentials monitoring for resection of gliomas within or close to motor related areas: validation of utility for predicting motor function2021

    • Author(s)
      Saito T, Muragaki Y, Tamura M, Maruyama T, Nitta M, Tsuzuki S, Ohashi M, Fukui A, Kawamata T
    • Journal Title

      Journal of Neurosurgery

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] nfluence of wide opening of the lateral ventricle on survival for supratentorial glioblastoma patients with radiotherapy and concomitant temozolomide-based chemotherapy.2020

    • Author(s)
      Taiichi Saito, Yoshihiro Muragaki, Takashi Maruyama, Takashi Komori, Masayuki Nitta, Shunsuke Tsuzuki, Atsushi Fukui, Takakazu Kawamata
    • Journal Title

      Neurosurgical review

      Volume: - Issue: 6 Pages: 1583-1593

    • DOI

      10.1007/s10143-019-01185-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between localization of supratentorial glioma to the precentral gyrus and difficulty in identification of the motor area during awake craniotomy2020

    • Author(s)
      Taiichi Saito, Yoshihiro Muragaki, Manabu Tamura, Takashi Maruyama, Masayuki Nitta, Shunsuke Tsuzuki, Atsushi Fukui, Takakazu Kawamata
    • Journal Title

      Journal of Neurosurgery

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Awake craniotomy with transcortical motor evoked potential monitoring for resection of gliomas in the precentral gyrus: utility for predicting motor function2019

    • Author(s)
      Saito T, Muragaki Y, Tamura M, Maruyama T, Nitta M, Tsuzuki S, Fukuchi S, Ohashi M, Kawamata T
    • Journal Title

      J Neurosurg

      Volume: - Issue: 4 Pages: 1-11

    • DOI

      10.3171/2018.11.jns182609

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 覚醒下手術とCCEPモニタリングを併用した優位半球前頭葉弁蓋部に進展する神経膠腫の摘出戦略2022

    • Author(s)
      齋藤太一, 村垣善浩, 田村学, 丸山隆志, 新田雅之, 都築俊介, 福井敦, 郡山峻一, 川俣貴一
    • Organizer
      第31回脳神経外科手術と機器学会 (CNTT2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Malignancy index using intraoperative flow cytometry is a valuable prognostic factor for glioblastoma treated with standard chemo-radiotherapy2022

    • Author(s)
      Saito T, Muragaki Y, Nitta M, Tsuzuki S, Fukui A, Koriyama S, Kawamata T
    • Organizer
      Computer Assisted Radiology and Surgery 36th International Congress and Exhibition
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Large sizeの島回神経膠腫に対する積極的摘出と機能温存の両立への挑戦2022

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 新田雅之, 都築俊介, 郡山峻一, 桑野淳, 川俣貴一
    • Organizer
      第27回日本脳腫瘍の外科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 優位半球前頭葉弁蓋部に進展する神経膠腫に対する6連strip電極を用いたCCEP測定の実際2022

    • Author(s)
      齋藤太一, 村垣善浩, 田村学, 新田雅之, 都築俊介, 郡山峻一, 川俣貴一
    • Organizer
      日本脳神経外科学会第81 回学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 多様な手術支援機器を活用した悪性神経膠腫の手術2022

    • Author(s)
      齋藤太一
    • Organizer
      第42回日本脳神経外科コングレス総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 非優位半球側グリオーマに対する覚醒下手術の必要性についての検討2022

    • Author(s)
      齋藤太一, 村垣善浩, 田村学, 仁木千晴, 新田雅之, 角田明子, 都築俊介, 郡山峻一, 川俣貴一
    • Organizer
      第20回日本Awake Surgery学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] グリオーマにおけるCT、メチオニンPET所見と1p/19q欠失2021

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 新田雅之, 都築俊介, 福井敦, 川俣貴一
    • Organizer
      第44回日本脳神経CI学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 上顎洞の粘膜肥厚の合併は神経膠腫症例に多く膠芽腫症例においては予後不良因子である2020

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 新田雅之, 生田聡子, 都築俊介, 福井敦, 小森隆司, 川俣貴一
    • Organizer
      第38回日本脳腫瘍学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 覚醒下手術による言語・運動系機能の温存2020

    • Author(s)
      齋藤太一
    • Organizer
      第40回日本脳神経外科コングレス総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 運動野・錐体路内および近傍部神経膠腫の摘出術における覚醒下手術・経皮質MEPモニタリング併用の有用性2020

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 田村学, 新田雅之, 都築俊介, 福井敦, 川俣貴一
    • Organizer
      第25回日本脳腫瘍の外科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 運動野・錐体路内および近傍部神経膠腫の摘出術における覚醒下手術・経皮質MEPモニタリング併用の有用性2020

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 田村学, 都築俊介, 福井敦, 川俣貴一
    • Organizer
      第17回日本Awake Surgery学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 術中言語野、運動野の同定が困難となる因子についての検討-20年間のAwake surgeryの経験から得られた知見2020

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 新田雅之, 都築俊介, 福井敦, 川俣貴一
    • Organizer
      第79回日本脳神経外科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] SCOTの状況と他科での応用2020

    • Author(s)
      齋藤太一
    • Organizer
      日本脳神経外科学会 第79回学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Recommended Practices for Neuro-monitoring in Glioblastoma.2019

    • Author(s)
      Saito T (invited speaker), Muragaki Y, Maruyama T, Kawamata T
    • Organizer
      Congress of Neurological Surgery Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 標準的治療を受けた膠芽腫症例において術中の広い脳室開放が生存予後に与える影響についての検討2019

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 新田雅之, 都築俊介, 福井敦, 川俣貴一
    • Organizer
      第78回日本脳神経外科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] グリオーマ手術における術中フローサイトメトリーの有用性2019

    • Author(s)
      齋藤太一, 村垣善浩, 丸山隆志, 新田雅之, 都築俊介, 福井敦, 川俣貴一
    • Organizer
      第24回日本脳腫瘍の外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] COMBINED AWAKE CRANIOTOMY AND TRANSCORTICAL MEP FOR RESECTION OF MOTOR AREA GLIOMAS2018

    • Author(s)
      Taiichi Saito Yoshihiro Muragaki Takashi Maruyama Manabu Tamura Masayuki Nitta Takakazu Kawamata
    • Organizer
      Society for Neurooncology, 23rd Annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2024-01-30  

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