| Project/Area Number |
18K09015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
萩原 嘉廣 東北大学, 医学系研究科, 准教授 (90436139)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Muscle pain / Inflammasome / Uric acid / Electrical stimulation / Mechanical hyperalgesia / inflammasome / uric acid / muscle pain / 筋痛 |
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| Outline of Final Research Achievements |
This study elucidates whether elevated uric acid levels, inflammasome activation, and pro-inflammatory cytokine elevation are associated with the development of myalgia in muscle tissue pained by hypercontraction. As a result of evaluation by a mouse myalgia model, uric acid concentration, inflammasome-related protein, and pro-inflammatory cytokine were significantly increased in the myalgia group, and myalgia was improved by administration of various inhibitors. From this, it was found that inflammasome activation and pro-inflammatory cytokine elevation are involved in myalgia.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により、過剰収縮により生じた筋痛におけるinflammasomeの活性化・pro-inflammatory cytokineの上昇の関与が明らかになった。ことことから、尿酸やinflammasome、pro-inflammatory cytokine等を標的とした全く新しい筋痛治療法の開発が可能になる。特に尿酸生成阻害剤、尿酸排泄促進薬、IL-1βアンタゴニストなどは、既に他の病態に対して臨床応用されており、本研究の成果は、これらの薬剤の筋痛への臨床応用へと直結する。
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