• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Therapeutic strategy for osteoarthritis by targeting neuropeptides.

Research Project

Project/Area Number 18K09066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionHiroshima University

Principal Investigator

Nakasa Tomoyuki  広島大学, 病院(医), 講師 (60467769)

Co-Investigator(Kenkyū-buntansha) 安達 伸生  広島大学, 医系科学研究科(医), 教授 (30294383)
味八木 茂  広島大学, 病院(医), 講師 (10392490)
石川 正和  広島大学, 医系科学研究科(医), 寄附講座准教授 (60372158)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords変形性関節症(OA) / 神経ペプチド / 変形性関節症 / microRNA
Outline of Final Research Achievements

In the OA pathogenesis, cartilage degeneration due to the subchondral bone sclerosis and degenerations of the tissues such as menisci and ligament occur. Identification of factors which causes these changes will lead to develop new treatment. We focused on neuropeptides which have various functions such as bone metabolism and angiogenesis as well as pain. We showed that neuropeptides are involved in the OA pathogenesis. The expression patterns of the calcitonin gene-related peptide (CGRP)、vasoactive intestinal peptide (VIP)、substance P were examined in human OA and OA model mice. The expression of these neuropeptides increased with the sclerotic changes of the subchondral bone. Interaperitoneal administration of CGRP, VIP receptor antagonist, and substance P agonist to OA model mice could suppress the OA progression. In addition, RNA sequence of microRNA using OA model mice serum revealed some expression patterns during OA progression.

Academic Significance and Societal Importance of the Research Achievements

これまでのOAの病態における研究は、関節軟骨や炎症性サイトカイン、軟骨基質分解酵素等に関するものが多かった。またOAにおける神経ペプチドの研究も散見されるが、これらは疼痛に関するものであった。本研究では、神経ペプチドが疼痛だけではなく、骨代謝や炎症、血管新生等にも関わっており、治療標的となる可能性が示唆できた。現状では、OAの進行を遅らせる薬剤はない。神経ペプチド受容体拮抗薬は、偏頭痛の治療薬等で実際に臨床において使用できるものもあり、drug repositioningにより、新たなOAの治療薬に発展するものと思われる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone2020

    • Author(s)
      Kanemitsu Munekazu、Nakasa Tomoyuki、Shirakawa Yoshiko、Ishikawa Masakazu、Miyaki Shigeru、Adachi Nobuo
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 25 Issue: 5 Pages: 897-906

    • DOI

      10.1016/j.jos.2019.11.010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone.2020

    • Author(s)
      Kanemitsu M, Nakasa T, Shirakawa Y, Ishikawa M, Miyaki S, Adachi N
    • Journal Title

      Journal of Orthopaedic Science

      Volume: in press

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 靭帯変性における神経ペプチドの発現解析2020

    • Author(s)
      徳本真矢、中佐智幸、石川正和、生田祥也、味八木茂、金光宗一、白川圭子、安達伸生
    • Organizer
      第35回日本整形外科学会基礎学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 変形性膝関節症におけるsubstance Pの治療効果の検討2019

    • Author(s)
      白川圭子、中佐智幸、金光宗一、石川正和、眞田洋平、味八木茂、安達伸生
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 変形性膝関節症におけるsubstance Pの軟骨・半月板での発現2018

    • Author(s)
      白川圭子、中佐智幸、金光宗一、石川正和、味八木茂、安達伸生
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 半月板変性におけるvasoactive intestinal peptide(VIP)の関連2018

    • Author(s)
      金光宗一、中佐智幸、白川圭子、石川正和、味八木茂、安達伸生
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi