Development of a novel osteoporosis diagnostic device using acoustically stimulated electromagnetic response

• Project/Area Number: 18K09092
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Tohoku University
• Principal Investigator: Akira Ando 東北大学, 医学系研究科, 大学院非常勤講師 (90810581)
• Co-Investigator(Kenkyū-buntansha): 萩原 嘉廣 東北大学, 医学系研究科, 准教授 (90436139)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 骨粗鬆症 / 超音波誘起電磁応答 / 骨質 / コラーゲン / 超音波誘起電磁波 / ASEM信号 / 圧電効果 / 音響誘起電磁波

Outline of Final Research Achievements

Bone fracture is a major factor in the elderly requiring support and care, and has become a major social problem. Osteoporosis is caused by a decrease in bone strength, and bone strength consists of two factors, bone density and bone quality, but bone quality has not been evaluated yet. In this study, we succeeded in detecting the changes caused by osteoporosis using the ASEM method, which is a non-invasive method to measure the electrical and magnetic properties of objects by detecting acoustically stimulated electromagnetic waves (ASEM waves), suggesting the possibility of using the ASEM method to evaluate bone quality.

Academic Significance and Societal Importance of the Research Achievements

現在骨粗鬆症の診断は骨密度の評価のみによって行われ、骨質の評価はなされていない。高齢化が進む本邦において骨粗鬆症の適切な診断・治療を増進し、骨折を予防することは急務である。本研究ではASEM法を使用し骨粗鬆症に生じる変化を検出することに成功し、骨質評価の可能性が示唆された。非侵襲的に骨質を評価する全く新しい診断法の可能性が示され、骨粗鬆症の診断・治療の進歩につながることが期待される。

Research Products

• [Presentation] 骨粗鬆症モデルラット大腿骨に対する音響誘起電磁法による画像診断装置の開発 (2020)
  • Author(s): 小島良績、新実信夫、生嶋健司、矢部裕、萩原嘉廣
  • Organizer: 第93回日本超音波医学会学術集会
• [Presentation] 音響誘起電磁法によって測定されたラット骨粗鬆症モデルの大腿骨における圧電性の低下 (2020)
  • Author(s): 萩原嘉廣
  • Organizer: 第93回日本超音波医学会学術集会
• [Presentation] Acoustically stimulated electric polarization in osteoporotic bone. (2019)
  • Author(s): Kojima Y, Niimi, N, Ikushima K, Yabe Y, Hagiwara Y
  • Organizer: ASBMR 2019, Orlando, Florida, USA
  • Int'l Joint Research
• [Presentation] Acoustically stimulated electromagnetic response in Biomedical Tissues (2018)
  • Author(s): Ikushima K, Yamada H, Niimi N, Kojima Y, Yabe Y, Hagiwara Y
  • Organizer: IEEE IUS 2018
  • Int'l Joint Research