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Elucidation of pain mechanisms mediated by mechanosensitive channel in knee osteoarthritis

Research Project

Project/Area Number 18K09117
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionWakayama Medical University

Principal Investigator

Nishio Naoko  和歌山県立医科大学, 医学部, 特別研究員 (40648359)

Co-Investigator(Kenkyū-buntansha) 谷口 亘  和歌山県立医科大学, 医学部, 客員研究員 (20453194)
山中 学  和歌山県立医科大学, 医学部, 助教 (30597084)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords変形性膝関節症 / 疼痛 / 機械受容チャネル / 荷重時痛 / 膝関節 / 間接痛 / TRPV4 / CatWalk / 関節痛 / TRPV1 / パッチクランプ法
Outline of Final Research Achievements

Osteoarthritis (OA) of knee is a common disease in the elderly, and many patients have knee pain when walking or climbing stairs as chief complaints. However, the molecular mechanism of chronic pain in this disease has been unclear. The purpose of this study is to elucidate the pain mechanism by mechanical stimulation, focusing on transient receptor potential (TRP) channel and piezo channel. Behavioral experiments in knee OA model rats suggested that the activation or inhibition of TRPV1 channel and TRPV4 channel may have some effect on the pain mechanism of knee OA caused by mechanical stimulation.

Academic Significance and Societal Importance of the Research Achievements

本研究から変形性膝関節症の機械刺激による疼痛発生抑制メカニズムにTRPV1 チャネルと TRPV4 チャネルの活性化と阻害が関与していることが示唆された。本研究から得られたデータは変形性膝関節症だけでなく関節疾患全体の機械刺激による疼痛発生抑制メカニズムの解明の一助になりえる。また本データは変形性膝関節症病態生理学に基づく治療戦略を開発する際に分子レベルでの作用点としての可能性を示せ、臨床応用への一助となったと考える。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Analysis of the relationship between knee osteoarthritis weight-bearing pain and transient receptor potential vanilloid 1 using the CatWalk system2019

    • Author(s)
      Taniguchi W, Nishio N, Yamanaka M, Taiji R, Tsutsui S, Nakatsuka T, Yamada H.
    • Journal Title

      PAIN RESEARCH

      Volume: 印刷中

    • NAID

      130007742526

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 変形性膝関節症モデルラットにおけるTRPA1発現の電気生理学的検討2020

    • Author(s)
      玉井英伸, 山中学, 谷口亘, 太地良, 西尾尚子, 中塚映政, 山田宏
    • Organizer
      第13回日本運動器疼痛学会
    • Related Report
      2020 Research-status Report
  • [Presentation] TRPV1 activation involved in the pain of knee osteoarthritis -in vivo patch-clamp analysis-.2018

    • Author(s)
      Taniguchi W, Fukui D, Taniguchi T, Nishio N, Nakatsuka T, Yamada H
    • Organizer
      AOA & APKASS 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 変形性膝関節症モデルラットにおけるTRPV1関連痛の行動解析.2018

    • Author(s)
      谷口亘, 西尾尚子, 山中学, 太地良, 中塚映政, 山田宏.
    • Organizer
      第11回日本運動器疼痛学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 変形性膝関節症モデルラットにおけるTRPV1関連痛のCat Walkを用いた解析.2018

    • Author(s)
      谷口亘, 西尾尚子, 山中学, 谷口隆哉, 福井大輔, 中塚映政, 山田宏.
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] CatWalkを用いた変形性膝関節症における荷重時痛とTRPV1の関係性の解析.2018

    • Author(s)
      谷口亘, 西尾尚子, 山中学, 谷口隆哉, 福井大輔, 中塚映政, 山田宏
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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