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Brain damage and developmental defects in a mouse model of high-dose oxytocin oxytocin induced delivery

Research Project

Project/Area Number 18K09237
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionJuntendo University

Principal Investigator

ITAKURA ATSUO  順天堂大学, 医学部, 教授 (70262897)

Co-Investigator(Kenkyū-buntansha) 平山 貴士  順天堂大学, 医学部, 助教 (20816962)
小池 正人  順天堂大学, 大学院医学研究科, 教授 (80347210)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオキシトシン / 自閉症スペクトラム障害 / 分娩誘発 / 脳障害 / マウス / 脳性麻痺 / 分娩 / 陣痛
Outline of Final Research Achievements

In the present study, following a previous study, we performed a detailed analysis of brain damage in the prefrontal cortex of neonatal mouse pups induced by high-dose oxytocin (OXT)-induced parturition. Cell death was observed in the inferior and anterior limbic cortices of the ventral medial prefrontal cortex and in the cerebrospinal forceps in male pups born after high-dose OXT induction. These areas have been implicated in the autism spectrum, suggesting that they are susceptible to brain damage in male pups born after high-dose OXT-induced delivery.

Academic Significance and Societal Importance of the Research Achievements

オキシトシンは分娩誘発・促進剤として産科の処置で一般的に使用される薬剤であり、有害事象として過剰な子宮収縮によって、胎児へ低酸素性脳症などの有害事象が発生することが知られている。母獣への高用量でのオキシトシン投与は、過剰な子宮収縮を誘発させた今回の解析で影響を受けた領域は、自閉症スペクトラム障害など精神発達障害に関連する部位であった。疫学調査で分娩時オキシトシンを使用した児に精神発達障害が多いとの報告も見られ、オキシトシンによる過剰な子宮収縮と自閉症スペクトラム障害発症の関係があることが示唆された。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2021 2020

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Journal Article] Susceptibility of subregions of prefrontal cortex and corpus callosum to damage by high-dose oxytocin-induced labor in male neonatal mice2021

    • Author(s)
      Kitamura Eri、Koike Masato、Hirayama Takashi、Sunabori Takehiko、Kameda Hiroshi、Hioki Hiroyuki、Takeda Satoru、Itakura Atsuo
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 8 Pages: e0256693-e0256693

    • DOI

      10.1371/journal.pone.0256693

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin induced labor causes region and sex-specific transient oligodendrocyte cell death in neonatal mouse brain.2020

    • Author(s)
      Hirayama, T., Hiraoka, Y., Kitamura, E., Miyazaki, S., Horie, K., Fukuda, T., Hidema, S., Koike, M., Itakura, A., Takeda S.
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 141(46) Pages: 66-78

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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