Development of diagnosis of lymph node metastasis in uterine cancer by superparamagnetic iron oxide
| Project/Area Number |
18K09241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Kindai University |
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Principal Investigator |
SUZUKI Ayako 近畿大学, 医学部, 非常勤講師 (90378696)
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| Co-Investigator(Kenkyū-buntansha) |
松村 謙臣 近畿大学, 医学部, 教授 (20452336)
村上 幸祐 近畿大学, 医学部, 講師 (60734671)
佐藤 隆夫 近畿大学, 大学病院, 教授 (70162443)
柏木 伸夫 大阪大学, 医学系研究科, 特任教授(常勤) (30752745)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 超常磁性酸化鉄（SPIO） / SPIO造影MRI / リンパ節転移 / センチネルリンパ節 / 鉄染色 / 超常磁性酸化鉄(SPIO) / リンパ節転移診断 / 超常磁性酸化鉄製剤 |
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| Outline of Final Research Achievements |
In this study, we aimed to develop a novel method for the diagnosis of lymph node metastasis in cervical and endometrial cancers using Super Paramagnetic Iron Oxide (SPIO).
Contrast-enhanced magnetic resonance imaging (MRI) of the cervix using superparamagnetic iron oxide (SPIO) showed a preoperative positive diagnosis rate of 85%, which was higher than that of CT (67%) and PET-CT (71%).
In addition, it was suggested that SPIO could be an alternative tracer to radioisotope, and that sentinel lymph nodes could be identified using SPIO.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、治療前のリンパ節転移診断の精度が上昇し、正確なセンチネルリンパ節の検出が可能となり、従来見逃されていたLN転移が検出できるようになれば、患者の予後やQuality of life（QOL）の飛躍的な改善につながり、医療費削減や社会生産性の低下防止が期待できる。
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Reduction in HPV16/18 prevalence among young women with high‐grade cervical lesions following the Japanese HPV vaccination program2019
Author(s)
Matsumoto K, Yaegashi N, Iwata T, Yamamoto K, Aoki Y, Okadome M, Ushijima K, Kamiura S, Takehara K, Horie K, Tasaka N, Sonoda K, Takei Y, Aoki Y, Konnai K, Katabuchi H, Nakamura K, Ishikawa M, Watari H, Yoshida H, Matsumura N, Nakai H, Shigeta S, Takahashi F, Noda K, Yoshikawa H
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Journal Title
Cancer Science
Volume: 110
Issue: 12
Pages: 3811-3820
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] SPIO method for the diagnosis of pelvic lymph node metastasis2019
Author(s)
Murakami Kosuke, Suzuki Ayako, Ohsuga Takuma, Kai Sayaka, Fujishima Risa, Aoki Masato, Yo Yoshie, Takaya Hisamitsu, Kotani Yasushi, Nakai Hidekatsu, Tsuji Isao, Matsumura Noriomi
Organizer
第71回 日本産科婦人科学会
Related Report
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[Presentation] SPIO-MRIと鉄染色は、子宮頸癌・体癌のセンチネルリンパ節同定およびリンパ節転移診断に有用である2019
Author(s)
村上 幸祐, 鈴木 彩子, 佐藤 華子, 城 玲央奈, 大須賀 拓真, 甲斐 冴, 藤島 理沙, 青木 稚人, 葉 宜慧, 貫戸 明子, 高矢 寿光, 小谷 泰史, 中井 英勝, 辻 勲, 松村 謙臣
Organizer
第61回 婦人科腫瘍学会
Related Report
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