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Investigation of molecular mechanisms of middle ear cholesteatoma by the analysis of gene network involving bone destruction

Research Project

Project/Area Number 18K09388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionJuntendo University

Principal Investigator

haruyama takuo  順天堂大学, 医学部, 非常勤講師 (80549270)

Co-Investigator(Kenkyū-buntansha) 古川 正幸  順天堂大学, 医学部, 先任准教授 (20359524)
楠 威志  順天堂大学, 医学部, 教授 (30248025)
池田 勝久  順天堂大学, 医学部, 特任教授 (70159614)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨破壊 / 真珠腫性中耳炎 / 表皮細胞 / 線維芽細胞 / Th17細胞
Outline of Final Research Achievements

Bone destruction mediated by activation of Th17 cells is a phenomenon seen in rheumatoid arthritis, but the applicants found that the same Th17 cell-mediated bone destruction also occurred in cholesteatoma otitis media. did. From this result, the possibility of a new mechanism of "bone destruction caused by IL-17" was derived. Therefore, in this study, in order to elucidate the molecular pathology, we determined a gene network profile based on the expression analysis of specific genes related to bone destruction in cholesteatoma by in-vitro analysis. Specifically, using a culture system of epithelium, the behavior of genes induced by IL-17 was grasped at once by multiplex analysis. Based on the results of this profile, it will be useful for new treatment strategies for cholesteatoma.

Academic Significance and Societal Importance of the Research Achievements

中耳真珠腫の発症は全国で年間3,500-4,000症例と推察されている。現在、真珠腫性中耳炎の治療の中心は手術であるが、本研究の成果によって骨破壊を未然に防ぎ、顔面神経麻痺、めまい、難聴、髄膜炎などの重篤な合併症を回避させることは、患者救済に著しく貢献する。本課題に対して、真珠腫性中耳炎の骨破壊の免疫学的分子機構を分子レベルで解明し、治療戦略に新たな分子基盤を提供することが本研究の独創的かつ高い学術的特色である。今回の研究によって、真珠腫の骨破壊に関するターゲット遺伝子を解明することで新規の創薬の開発に繋がり、また手術を回避して保存的な治療が可能となり、臨床的に極めて意義深い研究となった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Association Between Earwax-Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population2021

    • Author(s)
      Hara Satoshi、Kusunoki Takeshi、Nakagawa Hiroshi、Toyoda Yu、Nojiri Shuko、Kamiya Kazusaku、Furukawa Masayuki、Takata Yusuke、Okada Hiroko、Anzai Takashi、Matsumoto Fumihiko、Ikeda Katsuhisa
    • Journal Title

      Otolaryngology Head and Neck Surgery

      Volume: - Issue: 1 Pages: 139-145

    • DOI

      10.1177/01945998211000374

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Right-sided Pyriform Sinus Fistula2018

    • Author(s)
      Sata Naoko、Higo Ryuzaburo、Yokoi Naoko、Haruyama Takuo、Yabe Ayumi、Kaga Akihito、Yoshikawa Hiroshi、Ikeda Katsuhisa
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 111 Issue: 1 Pages: 51-56

    • DOI

      10.5631/jibirin.111.51

    • NAID

      130006301035

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2018 Research-status Report
  • [Presentation] 人種・民族の耳垢型決定遺伝子ABCC11多型の差異と中耳真珠腫の発症リスク2021

    • Author(s)
      楠 威志, 原 聡, 岡田 弘子, 神谷 和作
    • Organizer
      第31回日本耳科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 外耳道真珠腫と耳垢型 ABCC11遺伝子多型についての検討2021

    • Author(s)
      岡田 弘子, 楠 威志, 原 聡, 神谷 和作, 高田 雄介, 古川 正幸, 池田 勝久
    • Organizer
      第31回日本耳科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 外科的治療が有効であった眼窩先端症候群の2例2019

    • Author(s)
      小島崇史,春山琢男,塩沢晃人 ,肥後隆三郎,池田勝久
    • Organizer
      第58回日本鼻科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] アレルギー性鼻炎の新たな治療2018

    • Author(s)
      春山琢男
    • Organizer
      第146回御茶ノ水耳鼻咽喉・頭頸科治療研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 不明熱の原因として腎血管筋脂肪腫が疑われた1症例2018

    • Author(s)
      小林 優子, 肥後 隆三郎, 春山 琢男, 山内 宏一, 塩澤 晃人, 陶 美梨, 大庭 亜由子, 井出 琢磨, 池田 勝久
    • Organizer
      第6回日本耳鼻咽喉科感染症・エアロゾル学会会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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