Phosphorescence Lifetime Map of Iridium-Complexed on choriocapillaris

Research Project

Project/Area Number	18K09397
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56060:Ophthalmology-related
Research Institution	Gunma University
Principal Investigator	Akiyama Hideo 群馬大学, 大学院医学系研究科, 教授 (60359586)
Co-Investigator(Kenkyū-buntansha)	松本英孝群馬大学, 医学部附属病院, 講師 (30420178) 向井亮群馬大学, 医学部附属病院, 講師 (70436327)
Project Period (FY)	2018-04-01 – 2021-03-31
Project Status	Completed (Fiscal Year 2020)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	イリジウム錯体 / りん光寿命 / 酸素分圧 / 眼底血流 / 共焦点顕微鏡 / りん光寿命マップ / 脈絡膜毛細管板 / 血行動態 / りん光 / 網膜
Outline of Final Research Achievements	Iridium complexes are attracting attention as luminescent materials for organic electroluminescence, and they emit phosphorescence with high efficiency when electricity is passed through them. Furthermore, iridium complexes do not emit light at normal oxygen partial pressures, but emit light at low oxygen levels. In addition, the phosphorescence lifetime of the iridium complex becomes longer under low oxygen than under steady state conditions. Together with our collaborator Tobita et al, we presented "Two-dimensional oxygen concentration based on phosphorescence lifetime measurement using a gated ICCD camera", which was published in the journal.
Academic Significance and Societal Importance of the Research Achievements	イリジウム錯体のりん光寿命を用いて酸素分圧を測定する礎ができた。人体投与や光学系のハードルはいまだ高いが、それらが解決できれば解明されていない脈絡毛細管板の循環動態に迫れる可能性がある。