Development of retinal disease regulation from prevention to therapeutic technology targeting hypoxia responses

• Project/Area Number: 18K09424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Keio University
• Principal Investigator: KURIHARA Toshihide 慶應義塾大学, 医学部(信濃町), 講師 (50365342)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 網膜 / 低酸素 / 血管新生 / 神経変性 / 外科 / 発生・分化 / トランスレーショナルリサ ーチ

Outline of Final Research Achievements

We aimed to establish anti-HIF therapies in order to prevent various ocular diseases and systemic malfunction. We have reported the therapeutic effect of a known HIF inhibitor topotecan in murine oxygen-induced retinopathy and ischemic reperfusion models. Furthermore, novel HIF inhibitors including halofuginone, hydroxycitric acid, lactoferrin, fish ingredients, vitamin B6, and fenofibrate have been screened. We have reported their therapeutic effects verified with various animal models. In addition, we have reported functions of a non-visual photoreceptor OPN5 in myopia progression inspired by the report of hypoxia response playing a role in myopia by another research group abroad.

Academic Significance and Societal Importance of the Research Achievements

研究開始前までに得られた異常な低酸素応答による網膜での病態形成知見を基に、食物由来因子ライブラリを用いた新たなスクリーニングを実施し、新規HIF阻害物質の同定ならびに、その治療効果を様々な動物モデルで検証した。本研究で得られた候補物質はいずれも日常的に摂取可能な機能性食品やサプリメントとして活用できる可能性があり、加齢黄斑変性のみならず糖尿病網膜症などの他の血管新生網膜疾患の治療、個体そのものの機能低下に対して、安全に介入できる可能性を見出した。また近視進行抑制の機序に関しても本研究を基に明らかとし、今後多くの臨床的な応用が期待できる成果を得た。

Research Products

• [Journal Article] Fenofibrate Protects against Retinal Dysfunction in a Murine Model of Common Carotid Artery Occlusion-Induced Ocular Ischemia (2021)
  • Author(s): Lee D, Tomita Y, Miwa Y, Jeong H, Mori K, Tsubota K, Kurihara T
  • Journal Title: Pharmaceuticals Volume: 14 Issue: 3 Pages: 223-223
  • DOI: 10.3390/ph14030223
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study (2021)
  • Author(s): Osamu Hieda , Takahiro Hiraoka , Takashi Fujikado,et al
  • Journal Title: Japanese Journal of Ophthalmology Volume: - Issue: 3 Pages: 315-325
  • DOI: 10.1007/s10384-021-00822-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term follow-up of a Chinese patient with KCNV2-retinopathy (2021)
  • Author(s): Lie H, Wang G, Liu X, Meng X, Long Y, Ren J, Yang L, Fujinami-Yokokawa Y, Kurihara T, Tsubota K, Fujinami K, Li S.
  • Journal Title: Ophthalmic Genet Volume: 42(2) Issue: 2 Pages: 144-149
  • DOI: 10.1080/13816810.2020.1861307
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Axial Length and Prevalence of Myopia among Schoolchildren in the Equatorial Region of Brazil (2020)
  • Author(s): Yotsukura Erisa、Torii Hidemasa、Ozawa Hiroko、Hida Richard Yudi、Shiraishi Tetsuro、Corso Teixeira Ivan、Rautha Yessa Vervloet Bertollo Lamego、Moraes do Nascimento Caio Felipe、Mori Kiwako、Uchino Miki、Kurihara Toshihide、Negishi Kazuno、Tsubota Kazuo
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 1 Pages: 115-115
  • DOI: 10.3390/jcm10010115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] xial length shortening in a myopic child with anisometropic amblyopia after wearing violet light-transmitting eyeglasses for 2 years. Am J Ophthalmol Case Rep (2020)
  • Author(s): Ofuji Y, Torii H, Yotsukura E, Mori K, Kurihara T, Negishi K, Tsubota K
  • Journal Title: Am J Ophthalmol Case Rep Volume: 20 Pages: 101002-101002
  • DOI: 10.1016/j.ajoc.2020.101002
  • Peer Reviewed / Open Access
• [Journal Article] Oral Bovine Milk Lactoferrin Administration Suppressed Myopia Development through Matrix Metalloproteinase 2 in a Mouse Model (2020)
  • Author(s): Ikeda Shin-Ichi、Kurihara Toshihide、Toda Masataro、Jiang Xiaoyan、Torii Hidemasa、Tsubota Kazuo
  • Journal Title: Nutrients Volume: 12 Issue: 12 Pages: 3744-3744
  • DOI: 10.3390/nu12123744
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of the Newly Invented Eyelid Clamper in Ultra-Widefield Fundus Imaging (2020)
  • Author(s): Ozawa N, Mori K, Katada Y, Tsubota K, Kurihara T
  • Journal Title: Life Volume: 10 Issue: 12 Pages: 323-323
  • DOI: 10.3390/life10120323
  • Peer Reviewed / Open Access
• [Journal Article] Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors (2020)
  • Author(s): Ibuki M, Lee D, Shinojima A, Miwa Y, Tsubota K, Kurihara T
  • Journal Title: Int J Mol Sci Volume: 21 Issue: 23 Pages: 8940-8940
  • DOI: 10.3390/ijms21238940
  • Peer Reviewed / Open Access
• [Journal Article] A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion (2020)
  • Author(s): Lee Deokho、Miwa Yukihiro、Jeong Heonuk、Ikeda Shin-ichi、Katada Yusaku、Tsubota Kazuo、Kurihara Toshihide
  • Journal Title: Journal of Visualized Experiments Volume: Nov 12 Issue: 165 Pages: 1-19
  • DOI: 10.3791/61865
  • Peer Reviewed / Open Access
• [Journal Article] PPARα Agonist Oral Therapy in Diabetic Retinopathy (2020)
  • Author(s): Tomita Y, Lee D, Tsubota K, Kurihara T
  • Journal Title: Biomedicines Volume: 8 Issue: 10 Pages: 433-433
  • DOI: 10.3390/biomedicines8100433
  • Peer Reviewed / Open Access
• [Journal Article] Association between axial length and choroidal thickness in early age-related macular degeneration (2020)
  • Author(s): Sato Maho、Minami Sakiko、Nagai Norihiro、Suzuki Misa、Kurihara Toshihide、Shinojima Ari、Sonobe Hideki、Akino Kunihiko、Ban Norimitsu、Watanabe Kazuhiro、Uchida Atsuro、Shinoda Hajime、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: PLOS ONE Volume: 15 Issue: 10 Pages: e0240357-e0240357
  • DOI: 10.1371/journal.pone.0240357
  • Peer Reviewed / Open Access
• [Journal Article] A Fairy Chemical Suppresses Retinal Angiogenesis as a HIF Inhibitor (2020)
  • Author(s): Lee Deokho、Miwa Yukihiro、Wu Jing、Shoda Chiho、Jeong Heonuk、Kawagishi Hirokazu、Tsubota Kazuo、Kurihara Toshihide
  • Journal Title: Biomolecules Volume: 10 Issue: 10 Pages: 1405-1405
  • DOI: 10.3390/biom10101405
  • Peer Reviewed / Open Access
• [Journal Article] Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane (2020)
  • Author(s): Akino Kunihiko、Nagai Norihiro、Watanabe Kazuhiro、Ban Norimitsu、Kurihara Toshihide、Uchida Atsuro、Shinoda Hajime、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: British Journal of Ophthalmology Volume: - Issue: 12 Pages: 1683-1687
  • DOI: 10.1136/bjophthalmol-2020-317478
  • Peer Reviewed / Open Access
• [Journal Article] RP2-associated retinal disorder in a Japanese cohort: Report of novel variants and a literature review, identifying a genotype-phenotype association. (2020)
  • Author(s): Fujinami K, Liu X, Ueno S, Mizota A, Shinoda K, Kuniyoshi K, Fujinami-Yokokawa Y, Yang L, Arno G, Pontikos N, Kameya S, Kominami T, Terasaki H, Sakuramoto H, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Yoshiake K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium Study Group.
  • Journal Title: Am J Med Genet C Semin Med Genet. Volume: 184 Issue: 3 Pages: 675-693
  • DOI: 10.1002/ajmg.c.31830
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy (2020)
  • Author(s): Tomita Y, Lee D, Miwa Y, Jiang X, Ohta M, Tsubota K, Kurihara T
  • Journal Title: Int J Mol Sci Volume: 21 Issue: 17 Pages: 6243-6243
  • DOI: 10.3390/ijms21176243
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and genetic characteristics of Stargardt disease in a large Western China cohort: Report 1 (2020)
  • Author(s): Liu X, Meng X, Yang L, Long Y, Fujinami-Yokokawa Y, Ren J, Kurihara T, Tsubota K, Tsunoda K, Fujinami K, Li S; East Asia Inherited Retinal Disease Society Study Group.
  • Journal Title: Am J Med Genet C Semin Med Genet Volume: 184(3) Issue: 3 Pages: 694-707
  • DOI: 10.1002/ajmg.c.31838
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Closure of macular hole secondary to ischemic hemi-central retinal vein occlusion by retinal photocoagulation and topical anti-inflammatory treatment (2020)
  • Author(s): Asato Teru、Nagai Norihiro、Suzuki Misa、Uchida Atsuro、Kurihara Toshihide、Ban Norimitsu、Minami Sakiko、Shinoda Hajime、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Lasers in Medical Science Volume: 36 Issue: 2 Pages: 469-471
  • DOI: 10.1007/s10103-020-03133-9
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and Genetic Characteristics of 15 Affected Patients From 12 Japanese Families with GUCY2D-Associated Retinal Disorder (2020)
  • Author(s): Liu X, Fujinami K, Kuniyoshi K, Kondo M, Ueno S, Hayashi T, Mochizuki K, Kameya S, Yang L, Fujinami-Yokokawa Y, Arno G, Pontikos N, Sakuramoto H, Kominami T, Terasaki H, Katagiri S, Mizobuchi K, Nakamura N, Yoshitake K, Miyake Y, Li S, Kurihara T, Tsubota K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium
  • Journal Title: Transl Vis Sci Technol Volume: 11 Issue: 6 Pages: 2-2
  • DOI: 10.1167/tvst.9.6.2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population. (2020)
  • Author(s): Fujinami K, Oishi A, Yang L, Arno G, Pontikos N, Yoshitake K, Fujinami-Yokokawa Y, Liu X, Hayashi T, Katagiri S, Mizobuchi K, Mizota A, Shinoda K, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Iwata T, Tsujikawa A, Tsunoda K; Japan Eye Genetics Consortium study group.
  • Journal Title: Am J Med Genet C Semin Med Genet. Volume: 184 Issue: 3 Pages: 656-674
  • DOI: 10.1002/ajmg.c.31826
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome (2020)
  • Author(s): Mushiga Yasuaki、Minami Sakiko、Uchida Atsuro、Nagai Norihiro、Suzuki Misa、Kurihara Toshihide、Sonobe Hideki、Ban Norimitsu、Watanabe Kazuhiro、Shinoda Hajime、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Journal of Clinical Medicine Volume: 9 Issue: 8 Pages: 2394-2394
  • DOI: 10.3390/jcm9082394
  • Peer Reviewed / Open Access
• [Journal Article] Spatial Functional Characteristics of East Asian Patients With Occult Macular Dystrophy (Miyake disease) (2020)
  • Author(s): Yang L, Joo K, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Pontikos N, Liu X, Nakamura N, Kurihara T, Tsubota K, Iwata T, Li H, Zou X, Wu S, Sun Z, Ahn SJ, Kim MS, Mun YS, Park KH, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K
  • Journal Title: Am J Ophthalmol Volume: 221 Pages: 169-180
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association (2020)
  • Author(s): Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
  • Journal Title: Sci Rep Volume: 12 Issue: 1 Pages: 9531-9531
  • DOI: 10.1038/s41598-020-65737-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retinal microglia are critical for subretinal neovascular formation. (2020)
  • Author(s): Usui-Ouchi A, Usui Y, Kurihara T, Aguilar E, Dorrell MI, Ideguchi Y, Sakimoto S, Bravo S, Friedlander M.
  • Journal Title: JCI insight Volume: 5 Issue: 12 Pages: 1391-1391
  • DOI: 10.1172/jci.insight.137317
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration (2020)
  • Author(s): Nagai Norihiro、Minami Sakiko、Suzuki Misa、Shinoda Hajime、Kurihara Toshihide、Sonobe Hideki、Watanabe Kazuhiro、Uchida Atsuro、Ban Norimitsu、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Journal of Clinical Medicine Volume: 9 Issue: 5 Pages: 1347-1347
  • DOI: 10.3390/jcm9051347
  • Peer Reviewed / Open Access
• [Journal Article] Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy (2020)
  • Author(s): Shoda Chiho、Miwa Yukihiro、Nimura Kazumi、Okamoto Kazutoshi、Yamagami Satoru、Tsubota Kazuo、Kurihara Toshihide
  • Journal Title: Nutrients Volume: 12 Issue: 4 Pages: 1055-1055
  • DOI: 10.3390/nu12041055
  • Peer Reviewed / Open Access
• [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency. (2020)
  • Author(s): Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-020-62119-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina (2020)
  • Author(s): Nagai Norihiro、Asato Teru、Minami Sakiko、Suzuki Misa、Shinoda Hajime、Kurihara Toshihide、Sonobe Hideki、Watanabe Kazuhiro、Uchida Atsuro、Ban Norimitsu、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Nutrients Volume: 12 Issue: 4 Pages: 888-888
  • DOI: 10.3390/nu12040888
  • Peer Reviewed / Open Access
• [Journal Article] Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization (2020)
  • Author(s): Ibuki M, Shoda C, Miwa Y, Ishida A, Tsubota K, Kurihara T
  • Journal Title: Front Pharmacol Volume: 11 Pages: 174-174
  • DOI: 10.3389/fphar.2020.00174
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study. (2020)
  • Author(s): Uchida A, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K, Kawasaki R, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 779-779
  • DOI: 10.1038/s41598-019-57260-7
  • NAID: 120007133035
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice (2020)
  • Author(s): Mori K, Kurihara T, Jiang X, Ikeda SI, Yotsukura E, Torii H, Tsubota K
  • Journal Title: Nutrients Volume: 12 Pages: 180-180
  • Peer Reviewed / Open Access
• [Journal Article] Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy. (2019)
  • Author(s): Misa Suzuki、Norihiro Nagai、Sakiko Minami、Toshihide Kurihara、Mamoru Kamoshita、Hideki Sonobe、Kazuhiro Watanabe、Hajime Shinoda、Kazuo Tsubota、Yoko Ozawa
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 258 Issue: 1 Pages: 49-56
  • DOI: 10.1007/s00417-019-04495-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy (2019)
  • Author(s): Minami Sakiko、Shinoda Hajime、Shigeno Yuta、Nagai Norihiro、Kurihara Toshihide、Watanabe Kazuhiro、Sonobe Hideki、Takagi Hitoshi、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 19056-19056
  • DOI: 10.1038/s41598-019-55544-6
  • Peer Reviewed / Open Access
• [Journal Article] The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects (2019)
  • Author(s): Terao Ryo、Honjo Megumi、Totsuka Kiyohito、Miwa Yukihiro、Kurihara Toshihide、Aihara Makoto
  • Journal Title: Prostaglandins & Other Lipid Mediators Volume: 145 Pages: 106365-106365
  • DOI: 10.1016/j.prostaglandins.2019.106365
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models (2019)
  • Author(s): Mori K, Kurihara T, Jiang X, Ikeda SI, Ishida A, Torii H, Tsubota K
  • Journal Title: Int J Mol Sci Volume: 20 Pages: 6014-6014
  • Peer Reviewed / Open Access
• [Journal Article] Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model (2019)
  • Author(s): Tomita Y, Ozawa N, Miwa Y, Ishida A, Ohta M, Tsubota K, Kurihara T
  • Journal Title: Int J Mol Sc Volume: 20 Issue: 23 Pages: 5878-5878
  • DOI: 10.3390/ijms20235878
  • Peer Reviewed / Open Access
• [Journal Article] Effect of midazolam, medetomidine, and butorphanol tartrate combination anesthetic on electroretinograms of mice (2019)
  • Author(s): Miwa Y, Tsubota K, Kurihara T
  • Journal Title: Mol Vis Volume: 25 Pages: 645-645
  • Peer Reviewed / Open Access
• [Journal Article] High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study. (2019)
  • Author(s): Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K.
  • Journal Title: J Cli Med Volume: 8 Issue: 11 Pages: 1788-1788
  • DOI: 10.3390/jcm8111788
  • NAID: 120007133033
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration (2019)
  • Author(s): Ibuki M, Shoda C, Miwa Y, Ishida A, Tsubota K, Kurihara T
  • Journal Title: Int J Mol Sci Volume: 20 Pages: 5049-5049
  • Peer Reviewed / Open Access
• [Journal Article] HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model (2019)
  • Author(s): Kunimi H, Miwa Y, Katada Y, Tsubota K, Kurihara T
  • Journal Title: PeerJ Volume: 7
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.1 (2019)
  • Author(s): Fujinami Kaoru、Yang Lizhu、Joo Kwangsic、Tsunoda Kazushige、Kameya Shuhei、Hanazono Gen、Fujinami-Yokokawa Yu、Arno Gavin、Kondo Mineo、Nakamura Natsuko、Kurihara Toshihide、Tsubota Kazuo、Zou Xuan、Li Hui、Park Kyu Hyung、Iwata Takeshi、Miyake Yozo、Woo Se Joon、Sui Ruifang
  • Journal Title: Ophthalmology Volume: - Issue: 10 Pages: 1432-1444
  • DOI: 10.1016/j.ophtha.2019.04.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ultra-Widefield Retinal Imaging for Analyzing the Association Between Types of Pathological Myopia and Posterior Staphyloma (2019)
  • Author(s): Mimura R, Mori K, Torii H, Nagai N, Suzuki M, Minami S, Ozawa Y, Kurihara T, Tsubota K
  • Journal Title: J Clin Med Volume: 8 Pages: 1505-1505
  • Peer Reviewed / Open Access
• [Journal Article] Current Prevalence of Myopia and Association of Myopia With Environmental Factors Among Schoolchildren in Japan. (2019)
  • Author(s): Erisa Yotsukura, Hidemasa Torii, Mikako Inokuchi, Mitsuaki Tokumura, Miki Uchino, Kyosei Nakamura, Mari Hyodo, Kiwako Mori, Xiaoyan Jiang, Shin-ichi Ikeda, Shinichiro Kondo, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
  • Journal Title: JAMA Ophthalmology Volume: 137(11) Issue: 11 Pages: 1233-1239
  • DOI: 10.1001/jamaophthalmol.2019.3103
  • Peer Reviewed / Open Access
• [Journal Article] The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial (2019)
  • Author(s): Mori K, Torii H, Fujimoto S, Jiang X, Ikeda SI, Yotsukura E, Koh S, Kurihara T, Nishida K, Tsubota K
  • Journal Title: Journal of Clinical Medicine Volume: 8 Issue: 8 Pages: 1179-1179
  • DOI: 10.3390/jcm8081179
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy (2019)
  • Author(s): Nagai Norihiro、Suzuki Misa、Minami Sakiko、Kurihara Toshihide、Kamoshita Mamoru、Sonobe Hideki、Watanabe Kazuhiro、Uchida Atsuro、Shinoda Hajime、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 11389-11389
  • DOI: 10.1038/s41598-019-47738-9
  • Peer Reviewed / Open Access
• [Journal Article] Ocular-Component-Specific miRNA Expression in a Murine Model of Lens-Induced Myopia (2019)
  • Author(s): Tanaka Y, Kurihara T, Hagiwara Y, Ikeda SI, Mori K, Jiang X, Torii H, Tsubota K
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 15 Pages: 3629-3629
  • DOI: 10.3390/ijms20153629
  • Peer Reviewed / Open Access
• [Journal Article] A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion (2019)
  • Author(s): Kunimi H, Miwa Y, Inoue H, Tsubota K, Kurihara T
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Pages: 3171-3171
  • Open Access
• [Journal Article] The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia (2019)
  • Author(s): Bucher F, Friedlander MSH, Aguilar E, Kurihara T, Krohne TU, Usui Y, Friedlander M
  • Journal Title: Neurochemistry International Volume: 129 Pages: 104489-104489
  • DOI: 10.1016/j.neuint.2019.104489
  • Peer Reviewed
• [Journal Article] Pharmacological HIF inhibition prevents retinal neovascularization with improved visual function in a murine oxygen-induced retinopathy model (2019)
  • Author(s): Miwa Y, Hoshino Y, Shoda C, Jiang X, Tsubota K, Kurihara T
  • Journal Title: Neurochemistry International Volume: 128 Pages: 21-31
  • DOI: 10.1016/j.neuint.2019.03.008
  • Peer Reviewed
• [Journal Article] QD laser eyewear as a visual field aid in a visual field defect model (2019)
  • Author(s): Iyama Chigusa、Shigeno Yuta、Hirano Eri、Kamoshita Mamoru、Nagai Norihiro、Suzuki Misa、Minami Sakiko、Kurihara Toshihide、Sonobe Hideki、Watanabe Kazuhiro、Shinoda Hajime、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1010-1010
  • DOI: 10.1038/s41598-018-37744-8
  • Peer Reviewed / Open Access
• [Journal Article] Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia (2019)
  • Author(s): Mori K, Kurihara T, Miyauchi M, Ishida A, Jiang X, Ikeda SI, Torii H, Tsubota K
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 295-295
  • DOI: 10.1038/s41598-018-36576-w
  • Peer Reviewed / Open Access
• [Journal Article] Inducement and Evaluation of a Murine Model of Experimental Myopia (2019)
  • Author(s): Jiang X, Kurihara T, Ikeda SI, Kunimi H, Mori K, Torii H, Tsubota K
  • Journal Title: Journal of Visualized Experiments Volume: 143 Issue: 143 Pages: 1-7
  • DOI: 10.3791/58822
  • Peer Reviewed
• [Journal Article] Evaluation of AAV-DJ vector for retinal gene therapy (2019)
  • Author(s): Katada Y, Kobayashi K, Tsubota K, Kurihara T
  • Journal Title: PeerJ Volume: 7 Pages: e6317-e6317
  • DOI: 10.7717/peerj.6317
  • Peer Reviewed / Open Access
• [Journal Article] Progress and Control of Myopia by Light Environments. (2018)
  • Author(s): Jiang X, Kurihara T, Torii H, Tsubota K
  • Journal Title: Eye & Contact Lens Volume: 44 Issue: 5 Pages: 273-278
  • DOI: 10.1097/icl.0000000000000548
  • Peer Reviewed
• [Journal Article] Lactobacillus paracasei</i> KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina (2018)
  • Author(s): Morita Y, Miwa Y, Jounai K, Fujiwara D, Kurihara T, Kanauchi O
  • Journal Title: Nutrients Volume: 10 Issue: 12 Pages: 1991-1991
  • DOI: 10.3390/nu10121991
  • Peer Reviewed / Open Access
• [Journal Article] 網膜橋渡し研究アップデート：1．分子標的薬（抗血管新生療法 (2018)
  • Author(s): 栗原俊英
  • Journal Title: 眼科 Volume: 12 Pages: 1513-1518
  • NAID: 40021741194
• [Presentation] VEGFの網膜の発生、生理、病態生理における役割 (2021)
  • Author(s): 栗原俊英
  • Organizer: 第7回栃木眼科疾患Forum
  • Invited
• [Presentation] キメラロドプシンを用いた視覚再生遺伝子治療の開発 (2021)
  • Author(s): 栗原俊英
  • Organizer: ゲノム創薬・創発フォーラム 第6回シンポジウム
  • Invited
• [Presentation] 多価不飽和脂肪酸CoA合成酵素ACSL6欠損マウスが示す加齢黄斑変性の表現型 (2021)
  • Author(s): 黒羽小羊子、堅田侑作、宍倉匡祐、三輪幸裕、坪田一男、栗原俊英、有田誠
  • Organizer: KGRI 基軸プロジェクト・長寿 研究最終報告会
• [Presentation] 低酸素応答制御に基づく 網膜視神経疾患への創薬 (2021)
  • Author(s): 栗原俊英
  • Organizer: 第40回日本眼薬理学会 シンポジウム１
  • Invited
• [Presentation] 進化と恒常性維持から考える 網膜治療技術開発 (2021)
  • Author(s): 栗原俊英
  • Organizer: 第７回ふくしま眼科フォーラム
  • Invited
• [Presentation] 糖尿病網膜症進展に関わる低酸素応答とその制御 (2020)
  • Author(s): 栗原俊英
  • Organizer: 第26回日本糖尿病眼学会総会/第35回日本糖尿病合併症学会総会
  • Invited
• [Presentation] 米国眼底写真データベースを用いた糖尿病網膜症分類アルゴリズムの日本人への適用 (2020)
  • Author(s): 小澤信博, 堅田侑作, 正好奏斗, 坪田一男, 栗原俊英
  • Organizer: 第26回日本糖尿病眼学会総会
• [Presentation] PPARαを標的とした 糖尿病網膜症治療の可能性 (2020)
  • Author(s): 栗原俊英
  • Organizer: 興和株式会社社内研修会
  • Invited
• [Presentation] 黄斑円孔に対する硝子体手術における内境界膜剥離の術後視野障害への影響 (2020)
  • Author(s): 秋野邦彦, 渡邊一弘, 篠田肇, 永井紀博, 栗原俊英, 内田敦郎, 伴紀充, 堀内直樹, 園部秀樹, 坪田一男, 小沢洋子
  • Organizer: 第59回日本網膜硝子体学会総会
• [Presentation] 中心性漿液性脈絡網膜症のマルチモーダルイメージングによる異常領域の検討 (2020)
  • Author(s): 篠島亜里, 小沢洋子, 内田敦郎, 永井紀博, 篠田肇, 栗原俊英, 鈴木美砂, 南早紀子, 坪田一男
  • Organizer: 第59回日本網膜硝子体学会総会
• [Presentation] 慶應大眼科において新型コロナウイルスが手術および硝子体内注射に与えた影響 (2020)
  • Author(s): 伴紀充, 秋野邦彦, 堀内直樹, 内田敦郎, 栗原俊英, 篠田肇, 坪田一男
  • Organizer: 第59回日本網膜硝子体学会総会
• [Presentation] 24.低酸素応答制御機能を持つ 静岡県産魚類由来成分の探索と疾患制御に関する研究 (2020)
  • Author(s): 栗原俊英, 正田千穂, 三輪幸裕
  • Organizer: MaOI-PARC (Marine Open Innovation Practical and Applied Research Center) 開所式
• [Presentation] 東京都内１幼稚園における近視有病率と近視関連因子の探索 (2020)
  • Author(s): 四倉絵里沙、鳥居秀成、森紀和子、羽入田明子、根岸一乃、栗原俊英、坪田一男
  • Organizer: 第74回日本臨床眼科学会
• [Presentation] 抗VEGF療法アップデート (2020)
  • Author(s): 栗原俊英
  • Organizer: 第74回日本臨床眼科学会
  • Invited
• [Presentation] 近視進行の分子メカニズムと治療ターゲット (2020)
  • Author(s): 栗原俊英
  • Organizer: 第74回日本臨床眼科学会
  • Invited
• [Presentation] バイオレットライトの分子機序解明から 得られたトランスレーショナル研究 (2020)
  • Author(s): 栗原俊英
  • Organizer: 第20回日本抗加齢医学会総会
  • Invited
• [Presentation] オプトジェネティクスによる網膜変性疾患の視覚再建 (2020)
  • Author(s): 栗原俊英
  • Organizer: 第68回日本臨床視覚生理学会 シンポジウム
  • Invited
• [Presentation] 網膜内DHA含有リン脂質による視機能調節機構の解析 (2020)
  • Author(s): 黒羽小羊子、堅田侑作、宍倉匡祐、三輪幸裕、坪田一男、栗原俊英、有田誠
  • Organizer: 第93回日本生化学会大会
• [Presentation] 網膜中DHA含有脂質の生理学的意義の解明 (2020)
  • Author(s): 黒羽小羊子、堅田侑作、宍倉匡祐、三輪幸裕、坪田一男、栗原俊英、有田誠
  • Organizer: 第2回KGRI基軸プロジェクト・長寿研究進捗報告会
• [Presentation] 強膜小胞体ストレスは近視進行における中心的分子機序である (2020)
  • Author(s): 池田真一、栗原俊英、姜効炎、坪田一男
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 都内1中学校における屈折値と過去の屋外活動時間との関連 (2020)
  • Author(s): 四倉絵里沙、鳥居秀成、井ノ口美香子、徳村光昭、森紀和子、姜効炎、内野美樹、根岸一乃、
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 房水ラマン分光装置開発におけるマウス角膜を用いた安全性検証 (2020)
  • Author(s): 篠島亜里、澤田澪、木下卓、池田真一、坪田一男、栗原俊英
  • Organizer: 第124回日本眼科学会総会
• [Presentation] ラクトフェリンの低酸素誘導因子阻害効果とマウス脈絡膜新生血管モデルでの治療的効果 (2020)
  • Author(s): 伊吹麻里、石田文子、正田千穂、三輪幸裕、坪田一男、栗原俊英
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 黄斑円孔に対する硝子体手術における内境界膜剥離の術後視野への影響 (2020)
  • Author(s): 秋野邦彦、渡邊 一弘、篠田肇、永井紀博、栗原俊英、内田敦郎、園部秀樹、坪田一男
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 網膜内DHA 含有リン脂質による視機能調節機構の解析 (2020)
  • Author(s): 黒羽小羊子、堅田侑作、宍 匡祐、三輪幸裕、坪田一男、栗原俊英、有田誠
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 魚類由来因子による低酸素応答制御を介した網脈絡膜病的血管新生抑制効果 (2020)
  • Author(s): 正田千穂、二村 視、三輪幸裕、岡本一利、山上聡、坪田一男、栗原俊英
  • Organizer: 第124回日本眼科学会総会
• [Presentation] 近視性脈絡膜新生血管に対する抗VEGF療法の視力予後に関する因子の検討 (2019)
  • Author(s): 虫賀庸朗, 永井紀博, 鈴木美砂, 南早紀子, 栗原俊英, 園部秀樹, 秋野邦彦, 渡邊一弘, 内田敦郎, 篠田肇, 坪田一男, 小沢洋子
  • Organizer: 第58回日本網膜硝子体学会総会
• [Presentation] 加齢黄斑変性における眼軸長と脈絡膜厚の関連の解析 (2019)
  • Author(s): 佐藤真帆, 永井紀博, 鈴木美砂, 南早紀子, 栗原俊英, 園部秀樹, 秋野邦彦, 渡邊一弘, 内田敦郎, 篠田肇, 坪田一男, 小沢洋子
  • Organizer: 第58回日本網膜硝子体学会総会
• [Presentation] 黄斑上膜に対する硝子体手術の術後に視野障害が出現した症例の6か月経過 (2019)
  • Author(s): 渡邊一弘, 栗原智樹, 篠田肇, 結城賢弥, 永井紀博, 栗原俊英, 内田敦郎, 伴紀充, 園部秀樹, 秋野邦彦, 坪田一男, 小沢洋子
  • Organizer: 第58回日本網膜硝子体学会総会
• [Presentation] サプリメントによる近視治療アプローチ (2019)
  • Author(s): 栗原俊英
  • Organizer: 第4回近視研究会学術集会
  • Invited
• [Presentation] 網膜の進化と恒常性維持 (2019)
  • Author(s): 栗原俊英
  • Organizer: 第29回群馬眼科フォーラム
  • Invited
• [Presentation] 健常者と加齢黄斑変性の僚眼の黄斑色素密度と視細胞外節長 (2019)
  • Author(s): 永井紀博, 鈴木美砂, 南早紀子, 栗原俊英, 園部秀樹, 渡邊一弘, 坪田一男, 小沢洋子
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] 東京都内の1中学校における1年間の屈折値変化量と眼軸長変化量 (2019)
  • Author(s): 四倉絵里沙, 鳥居秀成, 井ノ口美香子, 徳村光昭, 森紀和子, 姜効炎, 内野美樹, 根岸一乃, 栗原俊英, 坪田一男
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] 光遺伝学療法アップデート (2019)
  • Author(s): 栗原俊英
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] 近視進行の分子メカニズムと治療ターゲット (2019)
  • Author(s): 栗原俊英
  • Organizer: 第73回日本臨床眼科学会
• [Presentation] 網膜中DHA含有リン脂質の生理学的意義の解明 (2019)
  • Author(s): 黒羽 小羊子, 堅田 侑作, 宍倉 匡祐, 栗原 俊英, 有田誠
  • Organizer: 第13回メタボロームシンポジウム
• [Presentation] Proportion of light that reaches the mannequin's eye with or without eyeglass lenses under the sunshine (2019)
  • Author(s): Shinichiro Kondo, Xiaoyan Jiang, Naoki Otsuka, Daisuke Kaneda, Hidemasa Torii, Toshihide Kurihara, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conference
  • Int'l Joint Research
• [Presentation] The axial length changes by violet light exposure: 2-year outcome of two individual cases in a prospective clinical study (2019)
  • Author(s): Hidemasa Torii, Toshihide Kurihara, Shinichiro Kondo, Erisa Yotsukura, Kiwako Mori, Hidenaga Kobashi, Xiaoyan Jiang, Shin-ichi Ikeda, Ikuko Toda, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] A multicenter double-blinded randomized trial of oral crocetin for myopia progression in children (2019)
  • Author(s): Kiwako Mori, Hidemasa Torii, Satoko Fujimoto, Xiaoyan Jiang, Shin-ichi Ikeda, Erisa Yotsukura, Shizuka Koh, Toshihide Kurihara, Kohji Nishida, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Molecular pathways of the violet light effect on myopia progression (2019)
  • Author(s): Yumi Hagiwara, Toshihide Kurihara, Hidemasa Torii, Xiaoyan Jiang, Yasuhisa Tanaka, Masatsugu Nakamura, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Amlexanox activating EGR-1 suppresses myopia progression in a murine model of lens-induced myopia (2019)
  • Author(s): Yasuhisa Tanaka, Toshihide Kurihara, Xiaoyan Jiang, Kiwako Mori, Shin-ichi Ikeda, Yumi Hagiwara, Koushi Fujisawa, Masatomo Kato, Masatsugu Nakamura, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Retinal ERK activation is involved with myopia progression in mice (2019)
  • Author(s): Toshihide Kurihara, Yangsong Wang, Xiaoyan Jiang, Kiwako Mori, Hidemasa Torii, Shin-ichi Ikeda, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Violet wavelength specificity for suppression of myopia in a murine LIM model (2019)
  • Author(s): Xiaoyan Jiang, Toshihide Kurihara, Kiwako Mori, Shin-ichi Ikeda, Hidemasa Torii, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Gut microbiota affects myopia progression in a murine lens-induced myopia model (2019)
  • Author(s): Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Masataro Toda, Kiwako Mori, Hidemasa Torii, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Violet light hypothesis for prevention of myopia (2019)
  • Author(s): Kazuo Tsubota, Hidemasa Torii, Xiaoyan Jiang, Kiwako Mori, Yumi Tanaka, Yashihisa Tanaka, Shinichiro Kondo, Shin-ichi Ikeda, Toshihide Kurihara
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] Myopia crisis among school children in Tokyo (2019)
  • Author(s): Erisa Yotsukura, Hidemasa Torii, Mikako Inokuchi, Mitsuaki Tokumura, Miki Uchino, Kiwako Mori, Xiaoyan Jiang, Shin-ichi Ikeda, Shinichiro Kondo, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
  • Organizer: The 17th International Myopia Conferenc
  • Int'l Joint Research
• [Presentation] From violet light to crocetin: a translational research of myopia (2019)
  • Author(s): Toshihide Kurihara
  • Organizer: Special Interest Group Meeting on Photobiology of Myopia
  • Int'l Joint Research
• [Presentation] Fish ingredients inhibiting hypoxia-inducible factor suppress choroidal neovascularization and subretinal fibrosis in mice (2019)
  • Author(s): Chiho Shoda, Kazumi Nimura, Yukihiro Miwa, Kazutoshi Okamoto, Kauzo Tsubota, Toshihide Kurihara
  • Organizer: Marine Biotechnology Conference 2019
• [Presentation] 網膜中DHA含有リン脂質の視覚機能に及ぼす影響と生理学的意義の解明 (2019)
  • Author(s): 黒羽小羊子, 堅田侑作, 宍倉匡介, 三輪幸裕, 坪田一男, 栗原俊英, 有田誠
  • Organizer: 黒羽小羊子, 堅田侑作, 宍倉匡介, 三輪幸裕, 坪田一男, 栗原俊英, 有田誠
• [Presentation] 眼疾患への光生物学的アプローチ (2019)
  • Author(s): 栗原俊英
  • Organizer: 第3回OACiS -Ophthalmology Academic Club in Saitama-
  • Invited
• [Presentation] 網膜の発生、生理、病態生理に関わるVEGFの役割 (2019)
  • Author(s): 栗原俊英
  • Organizer: AMDエリア講演会 in Tokyo
  • Invited
• [Presentation] Omega-3 polyunsaturated fatty acids suppressed experimental myopia progression in mice (2019)
  • Author(s): Kiwako Mori, Toshihide Kurihara, Xiaoyan Jiang, Shin-ichi Ikeda, Makoto Arita, Hidemasa Torii, Kazuo Tsubota
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Oral lactoferrin administration suppresses lens-induced myopia in mice (2019)
  • Author(s): Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Masataro Toda, Kazuo Tsubota
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Internal limiting membrane peeling may cause post-operative visual field defects in epiretinal membrane patients (2019)
  • Author(s): Tomoki Kurihara, Kazuhiro Watanabe, Hideki Sonobe, Toshihide Kurihara, Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Protective effect of a novel HIF inhibitor halofuginone in a murine model of retinal ischemia-reperfusion (2019)
  • Author(s): Hiromitsu Kunimi, Yukihiro Miwa, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Wavelength Specificity of Violet Light on Suppressing Refractive Change and Axial Elongation in A Murine Model of Lens-induced Myopia (2019)
  • Author(s): Xiaoyan Jiang, Toshihide Kurihara, Kiwako Mori, Shin-ichi Ikeda, Hidemasa Torii, Kazuo Tsubota
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Detection of slight changes in the visual function using EvokeDx&reg; system in healthy adults (2019)
  • Author(s): Sakiko Minami, Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Mamoru Kamoshita, Hideki Sonobe, Kazuhiro Watanabe, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
  • Organizer: ARVO 2019 Annual Meeting
• [Presentation] Efficacy of the newly invented Eyelid Clamper in ultra-wide-field fundus imaging (2019)
  • Author(s): Nobuhiro Ozawa, Kiwako Mori, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Garcinia extract inhibiting HIF suppresses laser-induced CNV in mice (2019)
  • Author(s): Mari Ibuki, Chiho Shoda, Yukihiro Miwa, Kazuo Tsubot, Toshihide Kurihara
  • Organizer: ARVO 2019 Annual Meeting
• [Presentation] HIF inhibitor topotecan suppresses choroidal neovascularization and fibroproliferation in mice (2019)
  • Author(s): Chiho Shoda, Yukihiro Miwa, Ayako Ishida, Satoru Yamagami, Kazuo Tsubota, Toshihide Kurihara
  • Organizer: ARVO 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] オプトジェネティクスによる網膜変性疾患に対する視覚再建技術の構築 (2019)
  • Author(s): 栗原俊英
  • Organizer: 第123回日本眼科学会総会
  • Invited
• [Presentation] Function of VEGF in development, physiology, and pathophysiology of the retina (2019)
  • Author(s): 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] マウス近視誘導モデルにおけるラクトフェリンの近視進行抑制効果 (2019)
  • Author(s): 戸田匡太郎, 池田真一, 姜效炎, 栗原俊英, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] マウス近視モデルにおけるクロセチンの近視抑制効果 (2019)
  • Author(s): 森紀和子, 栗原俊英, 石田文子, 姜效炎, 池田真一, 鳥居秀成, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 近視誘導における強膜コラーゲン遺伝子発現プロファイルの変化 (2019)
  • Author(s): 池田真一, 栗原俊英, 姜效炎, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] マウス近視モデルにおけるバイオレットライト（VL）近視抑制効果の波長特異性 (2019)
  • Author(s): 姜效炎, 栗原俊英, 池田真一, 森紀和子, 鳥居秀成, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 米国眼底写真データベースを用いた糖尿病網膜症分類アルゴリズムの日本人への適用 (2019)
  • Author(s): 小澤信博, 堅田侑作, 正好奏斗, 坪田一男, 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 黄斑上膜に対する硝子体手術における内境界膜剥離の術後視野への影響 (2019)
  • Author(s): 栗原智樹, 渡邊一弘, 篠田肇, 永井紀博, 栗原俊英, 園部秀樹, 坪田一男, 小沢洋子
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 光生物学と眼の恒常性維持 (2019)
  • Author(s): 栗原俊英
  • Organizer: 第27回眼科若手研究者の会
• [Presentation] レーザー誘発性脈絡膜新生血管におけるHIF阻害剤の線維化抑制作用 (2019)
  • Author(s): 正田千穂, 三輪幸裕, 石田文子, 山上聡, 坪田一男, 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 網膜虚血再灌流障害モデルにおけるHIFの関与と新規HIF阻害剤ハロフジノンの神経保護 (2019)
  • Author(s): 國見洋光, 三輪幸裕, 堅田侑作, 坪田一男, 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] マウス網膜光障害モデルにおける視細胞死に対するHIFの役割 (2019)
  • Author(s): 三輪幸裕, 坪田一男, 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 食物由来低酸素誘導因子阻害物質の探索とマウス脈絡膜新生血管モデルでの治療的効果 (2019)
  • Author(s): 伊吹麻里, 石田文子, 正田千穂, 三輪幸裕, 坪田一男, 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] AAV-DJベクターを用いた網膜遺伝子導入における発現毒性解析 (2019)
  • Author(s): 堅田侑作, 小林憲太, 坪田一男, 栗原俊英
  • Organizer: 第123回日本眼科学会総会
• [Presentation] ブラジル赤道部付近における学童の 1 年間の屈折値変化量と眼軸長変化量 (2019)
  • Author(s): 四倉絵里沙, 鳥居秀成, 内野美樹, 白石哲郎, 岡直幸, 森紀和子, 姜效炎, 池田真一, 栗原俊英, 根岸一乃, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] バイオレットライトを使用した前向き研究における成人強度近視 2 症例の眼軸長伸長量 (2019)
  • Author(s): 鳥居秀成, 戸田郁子, 大野綾香, 近藤眞一郎, 四倉絵里沙, 森紀和子, 小橋英長, 姜效炎, 池田真一, 栗原俊英, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 強度近視に伴う後部ぶどう腫と病的近視合併症の関連 (2019)
  • Author(s): 安璃々子, 森紀和子, 永井紀博, 鈴木美砂, 南早紀子, 小沢洋子, 栗原俊英, 坪田一男
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化 (2019)
  • Author(s): 栗原俊英, 有田陽子, 日高悠葵, 西恭代, 常吉由佳里, 鳥居秀成, 木下卓, 西崎早織, 白川佳則, 木村 翔, 坪田一男, 根岸一乃
  • Organizer: 第123回日本眼科学会総会
• [Presentation] 低酸素応答制御による網膜疾患克服の試み (2019)
  • Author(s): 栗原俊英
  • Organizer: 第3回感覚器研究イニシアチブ・シンポジウム
  • Invited
• [Presentation] 網膜の恒常性維持と加齢黄斑変性 (2019)
  • Author(s): 栗原俊英
  • Organizer: 第1回川崎市南部眼科病診連携の会
  • Invited
• [Presentation] 眼の進化と恒常性維持 (2019)
  • Author(s): 栗原俊英
  • Organizer: 第156回眼疾患研究会（ドーナッツセミナー）
  • Invited
• [Presentation] Application of hypoxia response regulation toward novel treatment in retinal diseases (2018)
  • Author(s): 栗原俊英
  • Organizer: 第57回日本網膜硝子体学会総会
  • Invited
• [Presentation] PCVに対する抗VEGF療法における脈絡膜所見と治療成績 (2018)
  • Author(s): 永井紀博、鈴木美砂、南早紀子、栗原俊英、渡邊一弘、園部秀樹、篠田肇、坪田一男、小沢洋子
  • Organizer: 第57回日本網膜硝子体学会総会
• [Presentation] モンテプラーゼ（tPA）硝子体内投与による黄斑下血腫の治療経過 (2018)
  • Author(s): 園部秀樹、篠田肇、鴨下衛、渡邊一弘、栗原俊英、永井紀博、坪田一男、小沢洋子
  • Organizer: 第57回日本網膜硝子体学会総会
• [Presentation] 視力良好例の網膜静脈分岐閉塞症に伴う黄斑浮腫に対するラニビズマブ投与の検討 (2018)
  • Author(s): 鈴木美砂、永井紀博、南早紀子、園部秀樹、鴨下衛、渡邊一弘、栗原俊英、篠田肇、
  • Organizer: 第57回日本網膜硝子体学会総会
• [Presentation] 前増殖糖尿病網膜症における無灌流領域割合と予後の関連 (2018)
  • Author(s): 大藤嘉子、堅田侑作、栗原俊英
  • Organizer: 平成30年度慶大眼科オータムセミナー
• [Presentation] 強度近視に伴う後部ぶどう腫と病的近視合併症の関連 (2018)
  • Author(s): 安璃々子、森紀和子、栗原俊英
  • Organizer: 平成30年度慶大眼科オータムセミナー
• [Presentation] 生物進化の過程から考える網膜の恒常性維持 (2018)
  • Author(s): 栗原俊英
  • Organizer: Nagasaki Retina Forum
  • Invited
• [Presentation] キメラロドプシンを用いた視覚再建効果の検討 (2018)
  • Author(s): 堅田侑作、吉田一帆、國見洋光、小林憲太、神取秀樹、坪田一男、栗原俊英
  • Organizer: 第72回日本臨床眼科学会
  • Invited
• [Presentation] 造血幹細胞移植後の新規ドライアイ発症例に近視化を伴った3症例 (2018)
  • Author(s): 伊藤賀一、小川葉子、清水映輔、栗原俊英、坪田一男
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化 (2018)
  • Author(s): 栗原俊英、有田陽子、日高悠葵、園部秀樹、内恭代、常吉由佳里、鳥居秀成、木下卓、西崎早織、白川佳則、木村翔、坪田一男、根岸一乃
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 超広角レーザー走査検眼鏡におけるソフト眼瞼固定器の有用性検討 (2018)
  • Author(s): 小澤信博、森紀和子、堅田侑作、有田陽子、坪田一男、栗原俊英
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 分子標的薬アップデート (2018)
  • Author(s): 栗原俊英
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 藻からヒトへ：進化を超えた網膜治療への挑戦 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第72回日本臨床眼科学会
  • Invited
• [Presentation] 近視進行の分子メカニズムと治療ターゲット (2018)
  • Author(s): 栗原俊英
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 網膜橋渡し研究アップデート2018 (2018)
  • Author(s): 栗原俊英、村上祐介、森實祐基、崎元晋、兼子裕規、大石明生
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 東京都内の1私立中学校における近視有病率 (2018)
  • Author(s): 四倉絵理沙、鳥居秀成、井ノ口美香子、徳村光昭、森紀和子、姜効炎、内野美樹、根岸一乃、栗原俊英、坪田一男
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 生体と人生のストレス応答 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第24回YOBC（若手眼科医の会）
  • Invited
• [Presentation] 眼の進化と加齢性変化 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第25回スポーツビジョン研究集会
  • Invited
• [Presentation] 糖尿病網膜症診療の現状と PPARαを標的とした治療の可能性 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第1回がんと生活習慣病の栄養学研究会
  • Invited
• [Presentation] 東京都内の1公立小学校における近視有病率 (2018)
  • Author(s): 鳥居秀成、四倉絵理沙、森紀和子、姜効炎、内野美樹、根岸一乃、栗原俊英、坪田一男
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 近視治療トータルコーディネート ～メカニズム研究、進行抑制、外科的治療～ (2018)
  • Author(s): 鳥居秀成、世古裕子、栗原俊英、二宮さゆり、木下望、稗田牧
  • Organizer: 第72回日本臨床眼科学会
• [Presentation] 近視進行メカニズムの分子生物学的理解と介入手段確立への取り組み (2018)
  • Author(s): 栗原俊英
  • Organizer: 第17回眼科生体防御研究会
  • Invited
• [Presentation] 網膜の進化と恒常性維持 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第8回 仙台網膜道場
  • Invited
• [Presentation] 網膜におけるVEGFの生理的な働き (2018)
  • Author(s): 栗原俊英
  • Organizer: AMD Update Seminar in多摩
  • Invited
• [Presentation] Distribution of generalized functional phenotype of East Asian Patients with Stargardt Disease (STGD1): EAStar studies report 2 (2018)
  • Author(s): Xiao Liu, Lizhu Yang, Kwangsic Joo, Kazushige Tsunoda, Takaaki Hayashi, Kei Shinoda, Atsushi Mizota, Mineo Kondo, Kazuki Kuniyoshi, Yu (Yokokawa) Fujinami, Gavin Arno, Toshihide Kurihara, Kazuo Tsubota, Yozo Miyake, Ya Li, Kyu Hyung Park, Dae Joong Ma, Hyeong Gon Yu, Bo Lei, Takeshi Iwata, Se Joon Woo
  • Organizer: 56th ISCEV Symposium
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4 (2018)
  • Author(s): Yu (Yokokawa) Fujinami, Lizhu Yang, Kwangsic Joo, Kazushige Tsunoda, Mineo Kondo, Gavin Arno, Xiao Liu, Toshihide Kurihara, Kazuo Tsubota, Xuan Zou, Hui Li, Kyu Hyung Park, Yozo Miyake, Takeshi Iwata, Se Joon Woo, Ruifang Sui, Kaoru Fujinami
  • Organizer: 56th ISCEV Symposium
  • Int'l Joint Research
• [Presentation] VEGFの網膜における生理的・病理的役割 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第43回日本微小循環学会総会
  • Invited
• [Presentation] WITHDRAWN - Incidence, Risk Factors, and Treatment of Retinopathy of Prematurity In Low-Birthweight Infants (2018)
  • Author(s): Tomoki Kurihara, Toshihide Kurihara, Norihiro Nagai, Mamoru Kamoshita, Yuki Hidaka, Hideki Sonobe, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Pemafibrate prevents retinal pathological neovascularization via systemic metabolic cascades in mice (2018)
  • Author(s): Yohei Tomita, Yukihiro Miwa, maki miyauchi, Ayako Ishida, Hiromitsu Kunimi, Yusaku katada, Kazuo Tsubota, Toshihide Kurihara
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Multimodal imaging of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease): EAOMD Report No. 3 (2018)
  • Author(s): Kwangsic Joo, Lizhu Yang, Kazushige Tsunoda, Mineo Kondo, Yu Fujinami, Gavin Arno, Toshihide Kurihara, Kazuo Tsubota, Takeshi Iwata, Xuan Zou, Hui Li, Yozo Miyake, Kyu Hyung Park, Kaoru Fujinami, Ruifang Sui, Se Joon Woo
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.1 (2018)
  • Author(s): Kaoru Fujinami, Lizhu Yang, Kwangsic Joo, Kazushige Tsunoda, Yuichi Kawamura, Yu Fujinami, Gavin Arno, Toshihide Kurihara, Kazuo Tsubota, Xuan Zou, Hui Li, Kyu Hyung Park, Takeshi Iwata, Yozo Miyake, Se Joon Woo, Ruifang Sui
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] The relationship between violet light transmittance of contact lenses and axial length elongation (2018)
  • Author(s): Hidemasa Torii, Toshihide Kurihara, Shinichiro Kondo, Xiaoyan Jiang, Kiwako Mori, Shin-cihi Ikeda, Erisa Yotsukura, Keiichi Kato, Kazuno Negishi, Kazuo Tsubota
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Violet light exposure suppresses refractive change and axial elongation in a murine model of lens-induced myopia (2018)
  • Author(s): Toshihide Kurihara, Xiaoyan Jiang, Kiwako Mori, Shin-cihi Ikeda, Hidemasa Torii, Kazuo Tsubota
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Predictive factors for better short-term outcome in idiopathic epiretinal membrane after pars plana vitrectomy (2018)
  • Author(s): Sakiko Minami, Yuta Shigeno, Hajime Shinoda, Norihiro Nagai, Toshihide Kurihara, Mamoru Kamoshita, Kazuhiro Watanabe, Hideki Sonobe, Yuki Hidaka, Kazuo Tsubota, Yoko Ozawa
  • Organizer: ARVO 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] 低酸素応答制御に基づく網膜疾患治療の可能性 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第122回日本眼科学会総会
  • Invited
• [Presentation] 低酸素応答を基軸としたトランスレーショナルリサーチの推進 (2018)
  • Author(s): 栗原俊英
  • Organizer: 第122回日本眼科学会総会
  • Invited
• [Presentation] マウス酸素誘導網膜症におけるHIF阻害剤の病的血管新生抑制効果 (2018)
  • Author(s): 三輪幸裕、宮内真紀、石田文子、堅田侑作、國見洋光、正田千穂、伊吹麻里、富田洋平、坪田一男、栗原俊英
  • Organizer: 第122回日本眼科学会総会
• [Presentation] バイオレットライト照射はマウス近視モデルにおける近視進行を抑制する (2018)
  • Author(s): 姜效炎、栗原俊英、森紀和子、池田真一、汪楊淞、鳥居秀成、坪田一男
  • Organizer: 第122回日本眼科学会総会
• [Presentation] 腸内細菌叢の撹乱が誘導マウス近視眼に及ぼす影響 (2018)
  • Author(s): 池田真一、栗原俊英、戸田匡太郎、姜効炎、坪田一男
  • Organizer: 第122回日本眼科学会総会
• [Presentation] キメラロドプシンを用いた視覚再建効果の検討 (2018)
  • Author(s): 堅田侑作、吉田一帆、國見洋光、小林憲太、神取秀樹、坪田一男、栗原俊英
  • Organizer: 第122回日本眼科学会総会
• [Presentation] レーザー誘発性脈絡膜新生血管に対するHIF阻害剤トポテカンの病的血管新生抑制作用 (2018)
  • Author(s): 正田千穂、三輪幸裕、伊吹麻里、宮内真紀、石田文子、山上聡、坪田一男、栗原俊英
  • Organizer: 第122回日本眼科学会総会
• [Presentation] 網膜虚血再灌流障害に対する新規HIF阻害剤ハロフジノンの神経保護作用 (2018)
  • Author(s): 國見洋光、三輪幸裕、堅田侑作、坪田一男、栗原俊英
  • Organizer: 第122回日本眼科学会総会
• [Presentation] VEGFの転写制御機構から考える 難治網膜疾患への新しい取り組み (2018)
  • Author(s): 栗原俊英
  • Organizer: 日本薬学会東海支部特別講演会
  • Invited
• [Book] 眼科 (2021)
  • Author(s): 栗原俊英
  • Total Pages: 100
  • Publisher: 金原出版株式会社
• [Book] あたらしい眼科 (2021)
  • Author(s): 富田洋平, 栗原俊英
  • Total Pages: 81
  • Publisher: 株式会社メディカル葵出版
• [Book] OCULISTA (2020)
  • Author(s): 栗原俊英
  • Total Pages: 82
  • Publisher: 全日本病院出版会
• [Book] 運動機能・認知機能改善食品の開発 (2020)
  • Author(s): 森紀和子、栗原俊英、坪田一男
  • Total Pages: 360
  • Publisher: シーエムシー出版
• [Book] 日本医事新報 (2019)
  • Author(s): 栗原俊英
  • Total Pages: 80
  • Publisher: 株式会社日本医事新報社
• [Book] Modern Physician (2019)
  • Author(s): 坪田一男, 近藤眞一郎, 早野元詞, 小橋英長, 堅田侑作, 栗原俊英, 明田直彦, 羽藤晋
  • Total Pages: 90
  • Publisher: 株式会社新興医学出版社
• [Book] 診療で役立つ！近視進行予防のサイエンス 第3章-2 (2019)
  • Author(s): 栗原俊英
  • Total Pages: 177
  • Publisher: 金原出版株式会社
• [Book] 診療で役立つ！近視進行予防のサイエンス 第3章-4 (2019)
  • Author(s): 姜効炎, 栗原俊英
  • Total Pages: 177
  • Publisher: 金原出版株式会社
• [Book] 診療で役立つ！近視進行予防のサイエンス 第3章-7 (2019)
  • Author(s): 栗原俊英
  • Total Pages: 177
  • Publisher: 金原出版株式会社
• [Patent(Industrial Property Rights)] HIF抑制用組成物 (2021)
  • Inventor(s): 栗原俊英、中井郁華、正田千穂、坪田一男
  • Industrial Property Rights Holder: 栗原俊英、中井郁華、正田千穂、坪田一男
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
• [Patent(Industrial Property Rights)] 小胞体ストレスまたはオールトランスレチナールに関連する疾患、障害または症状を治療または予防するため、または網膜厚を保護し、または網膜厚の萎縮もしくは萎縮進行を抑制するための組成物 (2020)
  • Inventor(s): 栗原俊英、堅田侑作、坪田一男
  • Industrial Property Rights Holder: 栗原俊英、堅田侑作、坪田一男
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
• [Patent(Industrial Property Rights)] 脈絡膜の菲薄化抑制装置及び方法 (2020)
  • Inventor(s): 姜效炎、森紀和子、栗原俊英、坪田一男
  • Industrial Property Rights Holder: 姜效炎、森紀和子、栗原俊英、坪田一男
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
• [Patent(Industrial Property Rights)] 低酸素誘導因子阻害剤 (2020)
  • Inventor(s): 河岸洋和、呉静、栗原俊英、三輪幸裕、正田千穂、イドクホ、坪田一男
  • Industrial Property Rights Holder: 河岸洋和、呉静、栗原俊英、三輪幸裕、正田千穂、イドクホ、坪田一男
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
• [Patent(Industrial Property Rights)] キメラロドプシンをコードする核酸コンストラクト (2019)
  • Inventor(s): 栗原俊英、堅田侑作、坪田一男、神取秀樹
  • Industrial Property Rights Holder: 栗原俊英、堅田侑作、坪田一男、神取秀樹
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 特定アミノ酸またはアミノ酸様物質による低酸素応答制御 (2019)
  • Inventor(s): 二村和視、高木毅、岡本一利、栗原俊英、正田千穂、坪田一男
  • Industrial Property Rights Holder: 二村和視、高木毅、岡本一利、栗原俊英、正田千穂、坪田一男
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 魚介類由来成分による低酸素応答制御 (2019)
  • Inventor(s): 二村和視、高木毅、岡本一利、栗原俊英、三輪幸裕、正田千穂
  • Industrial Property Rights Holder: 二村和視、高木毅、岡本一利、栗原俊英、三輪幸裕、正田千穂
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] ＨＩＦ抑制用組成物 (2019)
  • Inventor(s): 栗原俊英、伊吹麻里、坪田一男、蔀美和子
  • Industrial Property Rights Holder: 栗原俊英、伊吹麻里、坪田一男、蔀美和子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 視覚機能再生剤又は視覚機能低下予防剤 (2018)
  • Inventor(s): 栗原俊英、堅田侑作、國見洋光、坪田一男、神取秀樹
  • Industrial Property Rights Holder: 栗原俊英、堅田侑作、國見洋光、坪田一男、神取秀樹
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2020
• [Patent(Industrial Property Rights)] 近視予防剤及び近視進行抑制剤 (2018)
  • Inventor(s): 23.坪田一男、栗原俊英、鳥居秀成
  • Industrial Property Rights Holder: 23.坪田一男、栗原俊英、鳥居秀成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2020
• [Patent(Industrial Property Rights)] 近視予防用組成物及び機能性食品 (2018)
  • Inventor(s): 坪田一男、栗原俊英
  • Industrial Property Rights Holder: 坪田一男、栗原俊英
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2019
• [Patent(Industrial Property Rights)] 近視予防又は抑制剤、マウス近視誘導モデルの作製方法、及び、近視予防又は抑制医薬スクリーニング方法 (2018)
  • Inventor(s): 池田真一、姜 効炎、坪田一男、栗原俊英
  • Industrial Property Rights Holder: 池田真一、姜 効炎、坪田一男、栗原俊英
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2019
• [Patent(Industrial Property Rights)] 光学部材 (2018)
  • Inventor(s): 塩谷俊介、坪田一男、栗原俊英、鳥居秀成
  • Industrial Property Rights Holder: 塩谷俊介、坪田一男、栗原俊英、鳥居秀成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2019