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Investigation of incidence and features of rubella virus-associated uveitis

Research Project

Project/Area Number 18K09440
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Takase Hiroshi  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20451940)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords風疹ウイルス / ぶどう膜炎 / 硝子体生検 / 硝子体混濁 / 抗体率 / 眼内液検査 / PCR / フックス虹彩異色性虹彩毛様体炎
Outline of Final Research Achievements

Rubella virus (RV) has been implicated as a cause of uveitis, but its incidence and clinical feature are unknown in Japan. We performed a vitreous biopsy for patients with vitreous opacity. We found that among the patients who were differentially diagnosed with known uveitis entities or vitreoretinal lymphoma, nine patients (29%) were positive for antibodies for RV. These patients were mostly middle-aged men and showed unilateral disease with mild diffuse vitreous opacity. Small or medium keratic precipitates, cataracts, and secondary glaucoma were common. In some cases, diffuse iris atrophy was also seen. These results suggest that RV-associated uveitis is a distinct clinical entity, and a certain number of such patients is present in Japanese patients.

Academic Significance and Societal Importance of the Research Achievements

ぶどう膜炎は眼内に生じる炎症性疾患であり、失明予防のために適切な診断とそれに応じた治療が必要となる。しかし、ぶどう膜炎には未だ半数近くの分類不能症例が存在し、その治療を難しくしている。本研究は、我が国でこれまであまり注目されていなかった風疹に焦点をあて、単施設ながら風疹関連ぶどう膜炎が共通の臨床像を呈する確たる診断カテゴリとして一定の頻度で存在する事を明らかとした。この研究結果は、我が国のぶどう膜炎の原因疾患の中でこれまで原因不明とされていた一定の患者群に対して新たな疾患カテゴリを提唱するものとなり、それらの患者に対してより適切な医療が行える様になる事が期待されるものである。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2022 2020 2019

All Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Presentation] ぶどう膜炎診療における眼内液診断の実際2022

    • Author(s)
      高瀬 博
    • Organizer
      第11回豊の国眼科フォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] PCRを用いた眼炎症性疾患の診断とその変遷2020

    • Author(s)
      高瀬 博
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ぶどう膜炎眼内試料の解析と解釈2019

    • Author(s)
      高瀬 博
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 硝子体生検で風疹ウイルス抗体率陽性となったぶどう膜炎の臨床像2019

    • Author(s)
      井出 光直、高瀬 博、岩崎 優子、宮内 真理、堀口 乃恵、輕部 央子、宮永 将、池谷 頼子、田中美由紀、鴨居 功樹、大野 京子
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Usefulness of vitreous biopsy for steroid-resistant intermediate uveitis.2019

    • Author(s)
      Mitsunao Ide, Hiroshi Takase, Kyoko Ohno-Matsui
    • Organizer
      Global Ocular Inflammation Workshops 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Positivity of rubella virus in steroid-resistant intermediate uveitis of unknown etiology.2019

    • Author(s)
      Hiroshi Takase, Mitsunao Ide, Kyoko Ohno-Matsui.
    • Organizer
      The Association for Research in Vision and Ophthalmology Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 原因不明の硝子体混濁における風疹ウイルス抗体率に関する検討.2019

    • Author(s)
      井出光直、高瀬 博、岩崎優子、宮内真理、堀口乃恵、輕部央子、宮永 将、池谷頼子、大野京子.
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 原因不明の硝子体混濁における風疹ウイルス抗体率に関する検討2019

    • Author(s)
      井出光直、高瀬 博、岩崎優子、宮内真理、堀口乃恵、輕部央子、宮永 将、池谷頼子、大野京子
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Positivity of rubella virus in steroid-resistant intermediate uveitis of unknown etiology2019

    • Author(s)
      Hiroshi Takase, Mitsunao Ide, Kyoko Ohno-Matsui
    • Organizer
      The Association for Research and Vision and Ophthalmology 2019 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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