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Role of aqauaporin-4 in the aqueous humor dynamics

Research Project

Project/Area Number 18K09441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionNiigata University

Principal Investigator

Ueki Satoshi  新潟大学, 脳研究所, 助教 (90595117)

Co-Investigator(Kenkyū-buntansha) Huber Vincent  新潟大学, 脳研究所, 准教授 (40422620)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアクアポリン4 / post-iridial flow / glymphatic flow / アクアポリン / 眼圧 / 房水 / pos-iridial flow / 房水産生 / 緑内障 / マウス
Outline of Final Research Achievements

The purpose of this study was to clarify the role of aquaporin-4 in post-iridial flow, the pathway of aqueous humor through the vitreous to the retina. We performed JJ vicinal coupling proton exchange magnetic resonance imaging (JJVCPE MRI), a technique to observe the signal changes induced by H2(17)O injected through the femoral vein in aquaporin -4 knockout and control mice. The signal changes in the vitreous body were significantly greater in the aquaporin-4 knockout mice group than in the control mice group. This result suggests that H2(17)O injected into the femoral vein of mice becomes as a part of aqueous humor and flows into the vitreous body, and that the inflow of water from the vitreous into the retina via aquaporin-4 in Muller cells of the retina probably be diminished in aquaporin-4 knockout mice. The inflow of water into the retina via aquaporin-4 suggested in this study indicates that the system called glymphatic flow in the brain may also exist in the retina.

Academic Significance and Societal Importance of the Research Achievements

本研究は、網膜内にも脳内のglymphatic flowと呼ばれるシステムが存在する可能性を示した。脳内のglymphatic flowは老化に伴い有病率が増加するアルツハイマー病の病態に深く関わっているため、本研究の結果は老化に伴い有病率が増加する眼科疾患である緑内障や加齢黄斑変性の病態に網膜内のglymphatic flowが関わっている可能性をも示す。本研究は緑内障や加齢黄斑変性の病態の理解さらには治療への新たな扉を開く。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2021

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Retinal Aquaporin-4 and Regulation of Water Inflow Into the Vitreous Body2021

    • Author(s)
      Ueki Satoshi、Suzuki Yuji、Igarashi Hironaka
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 62 Issue: 2 Pages: 24-24

    • DOI

      10.1167/iovs.62.2.24

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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