| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To identify exosome-derived microRNAs involved in the distant metastasis of oral cancer, we were able to isolate highly invasive oral cancer cells and isolate exosomes from the supernatant of each cell culture, and comprehensively analyzed them by array analysis using parental cells as a control. As a result, we were able to identify two miR-Xs that commonly fold change in the three cells, referring to the database. The expression of the identified miR-Xs was not observed in peripheral blood and saliva of oral cancer patients. These results suggest that two miR-Xs derived from cancer cell exosomes may play an important role in the invasive ability that may be involved in oral cancer distant metastasis.
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