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Elucidation of transcriptional dysregulation by super-enhancer and oral squamous cell carcinoma progression

Research Project

Project/Area Number 18K09545
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57020:Oral pathobiological science-related
Research InstitutionKamakura Women's University (2019-2020)
Fujita Health University (2018)

Principal Investigator

Sakurai Kouhei  鎌倉女子大学, 家政学部, 准教授 (10608756)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔癌 / 扁平上皮癌 / 遺伝子転写制御 / 転移 / 高転移能亜株 / 転写制御 / スーパーエンハンサー
Outline of Final Research Achievements

Oral cancer, which is the most common malignancy in head and neck region, often shows metastasis, leading to poor prognosis. Therefore, it is clinically important to elucidate the molecular mechanisms of oral cancer metastasis.
The expressions of numerous genes are dysregulated in the metastatic process. The present study aimed at identifying genes associated with oral cancer metastasis, and revealing the mechanisms of the gene expression. By analyzing transcriptome of an oral cancer cell line with high metastatic potential, we revealed that several genes such as CSF2 (Colony Stimulating Factor2) were involved in oral cancer progression.

Academic Significance and Societal Importance of the Research Achievements

口腔癌は頭頸部癌の多くを占めており、その発症率は年々増加している。口腔領域にはリンパ管や血管が豊富に存在することから、口腔癌は頸部リンパ節や遠隔臓器へ転移を認めることが多い。転移の過程で変動する遺伝子を同定するとともに、それらの遺伝子を制御する分子機構を明らかにすることによって新たな治療法や診断マーカーの開発につながることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (20 results)

All 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 4 results) Presentation (10 results)

  • [Journal Article] Transcriptomic Profiling Predicts Multiple Pathways and Molecules Associated With the Metastatic Phenotype of Oral Cancer Cells2021

    • Author(s)
      IDETA YUKA、TAGAWA TAKANOBU、HAYASHI YUICHIRO、BABA JUNICHI、TAKAHASHI KIMIKO、MITSUDO KENJI、SAKURAI KOUHEI
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 18 Issue: 1 Pages: 17-27

    • DOI

      10.21873/cgp.20238

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 食道に発生した二相型滑膜肉腫の1例2020

    • Author(s)
      島寛太、櫻井浩平、酒井康弘、山田勢至、中川満、神永有紗、一安泰佑、塚本徹哉、松山篤二、浦野誠
    • Journal Title

      診断病理

      Volume: 37 Pages: 379-384

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX2019

    • Author(s)
      Okabe A, Kiriyama Y, Suzuki S, Sakurai K, Teramoto A, Kato H, Naiki-Ito A, Tahara S, Takahashi S, Kuroda M, Sugioka A, Tsukamoto T.
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 32 Issue: 2 Pages: 91-99

    • DOI

      10.1293/tox.2019-0007

    • NAID

      130007636048

    • ISSN
      0914-9198, 1881-915X
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Epilepsy-Associated Glioneuronal Tumor With Mixed Morphology Harboring FGFR1 Mutation2019

    • Author(s)
      Yamada S, Nobusawa S, Yamazaki T, Teranishi T, Watanabe S, Murayama K, Ohba S, Okabe A, Sakurai K, Urano M, Tsukamoto T, Yokoo H, Hirose Y, Abe M
    • Journal Title

      Pathology International

      Volume: 69 Issue: 6 Pages: 372-377

    • DOI

      10.1111/pin.12799

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma2019

    • Author(s)
      Sakurai K, Onouchi T, Yamada S, Baba Y, Murata T, Tsukamoto T, Kuroda M, Urano M.
    • Journal Title

      The Malaysian Journal of Pathology

      Volume: 41 Pages: 339-343

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum2019

    • Author(s)
      Urano Makoto、Nakaguro Masato、Yamamoto Yoshinari、Hirai Hideaki、Tanigawa Maki、Saigusa Natsuki、Shimizu Akira、Tsukahara Kiyoaki、Tada Yuichiro、Sakurai Kouhei、Isomura Madoka、Okumura Yuki、Yamaguchi Hiroshi、Matsubayashi Jun、Nagao Toshitaka
    • Journal Title

      The American Journal of Surgical Pathology

      Volume: 印刷中 Issue: 7 Pages: 984-994

    • DOI

      10.1097/pas.0000000000001258

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma.2018

    • Author(s)
      Minatsuki C, Yamamichi N, Inada KI, Takahashi Y, Sakurai K, Shimamoto T, Tsuji Y, Shiogama K, Kodashima S, Sakaguchi Y, Niimi K, Ono S, Niwa T, Ohata K, Matsuhashi N, Ichinose M, Fujishiro M, Tsutsumi Y, Koike K.
    • Journal Title

      Dig Dis Sci.

      Volume: 10 Issue: 10 Pages: 2617-2625

    • DOI

      10.1007/s10620-018-5179-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nectin1 expression is frequently decreased in gastric cancers.2018

    • Author(s)
      Takahashi Y, Yamamichi N, Inada KI, Shiogama K, Sakurai K, Takeuchi C, Mizutani Y, Tsutsumi Y, Koike K.
    • Journal Title

      Pathol Int.

      Volume: 10 Issue: 10 Pages: 557-562

    • DOI

      10.1111/pin.12721

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acquisition of resistance to androgen deprivation therapy in salivary duct carcinoma: A case report.2018

    • Author(s)
      Wasano K, Sakurai K, Kawasaki T, Kusafuka K, Kasahara M, Kondo N, Inada KI, Ogawa K.
    • Journal Title

      Rare Tumors

      Volume: 10 Pages: 1-5

    • DOI

      10.1177/2036361318798867

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transduced caudal-type homeobox (CDX) 2/CDX1 can induce growth inhibition on CDX-deficient gastric cancer by rapid intestinal differentiation2018

    • Author(s)
      Nakayama Chiemi、Yamamichi Nobutake、Tomida Shuta、Takahashi Yu、Kageyama-Yahara Natsuko、Sakurai Kouhei、Takeuchi Chihiro、Inada Ken-ichi、Shiogama Kazuya、Nagae Genta、Ono Satoshi、Tsuji Yosuke、Niimi Keiko、Fujishiro Mitsuhiro、Aburatani Hiroyuki、Tsutsumi Yutaka、Koike Kazuhiko
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 3853-3864

    • DOI

      10.1111/cas.13821

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ゼブラフィッシュを用いた、脈波と心電測定およびICG動脈硬化巣ライブイメージングによる総合的糖尿病合併症評価法2020

    • Author(s)
      伊藤太二、菅原沙恵子、櫻井浩平、相田萌花、赤田このみ、大橋由奈、小野詩織、鈴木さくら、中谷桃子、酒造麻実、三村明穂、大村正史、高橋君子、中谷弥栄子
    • Organizer
      第93回 日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] インスリン抵抗性特異的な血中分泌型miRNAの網羅的同定と標的遺伝子予測による糖尿病と合併症の新たな診断マーカーの探索2020

    • Author(s)
      大橋由奈、小野詩織、菅原沙恵子、櫻井浩平、相田萌花、赤田このみ、鈴木さくら、中谷桃子、酒造麻美、三村明穂、大村正史、高橋君子、中谷弥栄子、伊藤太二
    • Organizer
      第74回 日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゼブラフィッシュを用いた加速度脈波、心電、及びICG蛍光イメージングを組み合わせた総合的糖尿病合併症評価法2020

    • Author(s)
      赤田このみ、相田萌花、菅原沙恵子、櫻井浩平、大橋由奈、小野詩織、鈴木さくら、中谷桃子、酒造麻実、三村明穂、大村正史、高橋君子、中谷弥栄子、伊藤太二
    • Organizer
      第74回 日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 除菌後胃癌背景胃粘膜におけるDNAメチル化異常の蓄積2019

    • Author(s)
      田原沙佑美、田原智満、島寛太、磯村まどか、中川満、岡部麻子、櫻井浩平、桑原一彦、酒井康弘、山田勢至、浦野誠、黒田誠、塚本徹哉、大宮直木
    • Organizer
      第108回 日本病理学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 酵素抗原法の技術開発:パラフィン包埋切片において各種固定法が抗体活性におよぼす影響2018

    • Author(s)
      水谷泰憙、塩竈和也、尾之内高慶、櫻井浩平、稲田健一、堤寛
    • Organizer
      第107回 日本病理学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 歯原性病変におけるメラノサイトの局在と発生起源について2018

    • Author(s)
      磯村まどか、櫻井浩平、佐藤伸明、河合遼子、吉田和加、杉田好彦、久保勝俊、浦野誠、前田初彦
    • Organizer
      第29回 日本臨床口腔病理学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 耳下腺腫瘍の1例2018

    • Author(s)
      浦野誠、磯村まどか、櫻井浩平、黒田誠
    • Organizer
      第29回 日本臨床口腔病理学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] DNA二重鎖切断マーカーγ-H2AXを用いた胃発がん物質の短期同定2018

    • Author(s)
      岡部麻子、桐山諭和、鈴木周五、櫻井浩平、桑原一彦、高橋智、塚本徹哉
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] StageⅡ結腸・直腸S状部癌における癌先進部の低分化胞巣は再発のリスク因子になりうるか2018

    • Author(s)
      荒川敏、冨重博一、川辺則彦、永田英俊、浅野之夫、古田晋平、志村正博、林千紘、神尾健士郎、河合永季、安岡宏典、東口貴彦、今枝義博、稲田健一、櫻井浩平、石原慎、伊東昌広、堀口明彦
    • Organizer
      第23回 日本外科病理学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 甲状腺乳頭癌 篩状-モルラ型の一例2018

    • Author(s)
      櫻井浩平、中村豊、市川孝昭、馬場洋一郎、村田哲也、塚本徹哉、黒田誠、浦野誠
    • Organizer
      第57回 日本臨床細胞学会秋期大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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