Regulation of periodontitis by immunological network between oral cavity and intestinal tract
| Project/Area Number |
18K09546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57020:Oral pathobiological science-related
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Nagao Jun-ichi 福岡歯科大学, 口腔歯学部, 講師 (30509047)
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| Co-Investigator(Kenkyū-buntansha) |
田中 芳彦 福岡歯科大学, 口腔歯学部, 教授 (00398083)
成田 由香 福岡歯科大学, 口腔歯学部, 助教 (50758050)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯周病 / Porphyromonas gingivalis / Th17細胞 / Porphyromonas gingivitis / 歯周病原細菌 / 免疫応答 |
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| Outline of Final Research Achievements |
Periodontitis is a leading cause of tooth loss that is associated with a periodontal pathogenic bacterium. It has been reported that the pathogenesis of periodontitis is mediated by host immune response, especially IL-17A-producing helper T cells, Th17 cells. However, the regulatory mechanism to induce the immune response via Th17 cells by periodontal pathogens remains to be elucidated. In this study, we found that immunological network between oral cavity and intestinal tract is important for the development of periodontitis.
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| Academic Significance and Societal Importance of the Research Achievements |
従来の歯周病の治療・予防は、口腔内の歯垢や歯石の除去を主体としたのもであった。本研究で得られた成果により、歯周病発症を制御する腸内細菌や歯周病の病態形成に関わるTh17細胞を標的とした治療法や予防法が可能になる。このように歯周病に対する新しい治療法や予防法の開発への基盤を構築することができた。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Bacterial-induced maternal interleukin-17A pathway promotes autistic-like behaviors in mouse offspring2020
Author(s)
Yasumatsu K, Nagao J, Arita-Morioka K, Narita Y, Tasaki S, Toyoda K, Ito S, Kido H, Tanaka Y.
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Journal Title
Experimental Animals
Volume: 69
Issue: 2
Pages: 250-260
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mild Heat Stress Affects on the Cell Wall Structure in <i>Candida albicans</i> Biofilm2019
Author(s)
Ikezaki S, Cho T, Nagao J, Tasaki S, Yamaguchi M, Arita-Morioka K, Yasumatsu K, Chibana H, Ikebe T, Tanaka Y.
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Journal Title
Medical Mycology Journal
Volume: 60
Issue: 2
Pages: 29-37
DOI
NAID
ISSN
2185-6486, 2186-165X
Related Report
Peer Reviewed / Open Access
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