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Effect of trancription toward differentiation or proliferation of odontogenic epithelium in oncogenesis within the intraosseous microenvironment

Research Project

Project/Area Number 18K09549
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57020:Oral pathobiological science-related
Research InstitutionTohoku University

Principal Investigator

KUMAMOTO HIROYUKI  東北大学, 歯学研究科, 教授 (70215028)

Co-Investigator(Kenkyū-buntansha) 清水 良央  東北大学, 歯学研究科, 助教 (30302152)
及川 麻理子  東北大学, 歯学研究科, 助教 (00712902)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords歯原性腫瘍 / 腫瘍発生 / 骨内進展 / 細胞分化 / 転写因子
Outline of Final Research Achievements

Regulator molecules associated with neovascularized condition, development, and cell stemness were examined to clarify the effect of transcription system in
oncogenesis of odontogenic epithelium under the intraosseous microenvironment.
Neovascularization factors, EphA2, EphB4, and EphrinB2, were greater in ameloblastoma than in tooth germ, and measurement of CD34-positive microvessels and D2-40-positive lymphatic vessels was correlated positively with the Eph/Ephrin molecules. Development-related Hippo pathway signaling molecules, YAP and TAZ, were expressed higher in ameloblastoma than in tooth germ, whereas stem cell-associated transcription factors, Sox2 and Klf4, were lower in ameloblastoma than in tooth germ. These transcription factors also showed differences among histological variation and clinical behavior.

Academic Significance and Societal Importance of the Research Achievements

正常および腫瘍性の歯原性組織における脈管新生動態、発生の制御分子、幹細胞関連分子を検索し、腫瘍化による歯原性上皮細胞およびその微小環境の特異的な状況や特徴的な腫瘍組織所見・臨床病態との関連を見出した。これらによって、歯原性腫瘍を包括する骨内微小環境の形成要因および同微小環境下での歯原性上皮の増殖や分化に関わる転写調節について、検討することができた。これらの因子は、歯原性上皮が関わる様々な病変の診断や予後判定、治療に応用しうると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (33 results)

All 2021 2020 2019 2018

All Journal Article (17 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (5 results)

  • [Journal Article] Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma2021

    • Author(s)
      Siril YJ Kouketsu A Saito H Takahashi T Kumamoto H
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 50 Issue: 1 Pages: 27-32

    • DOI

      10.1016/j.ijom.2021.03.012

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immunohistochemical assessment of Eph/Ephrin expression in ameloblastomas2020

    • Author(s)
      Obara N Oikawa M Mizoguchi I Takano-Yamamoto T Kumamoto H
    • Journal Title

      Tohoku Univ Dent J

      Volume: 37-39 Pages: 1-10

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pediatric cemento-ossifying fibroma of the anterior mandible2020

    • Author(s)
      Miyashita H Suzuki H Matsui K Sato N Kitamura J Kumamoto H Takahashi T
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: 32 Issue: 4 Pages: 285-290

    • DOI

      10.1016/j.ajoms.2020.03.007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Florid Cemento-osseous Dysplasia-associated Simple Bone Cyst Showing Marked Irregular Border and High Apparent Diffusion Coefficient Value2020

    • Author(s)
      Kojima I, Nishioka T, Sakamoto M, Sai Y, Ezoe Y, Iikubo M, Kumamoto H, Takahashi T.
    • Journal Title

      Case Rep Dent

      Volume: - Pages: 8854428-8854428

    • DOI

      10.1155/2020/8854428

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 当科における口腔細胞診と組織診断の比較検討2020

    • Author(s)
      野上晋之介 山内健介 柳沢佑太 宮下仁 熊本裕行 髙橋哲
    • Journal Title

      東北大歯誌

      Volume: 37-39 Pages: 11-16

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical assessment of growth factor signaling olecules: MAPK, Akt, and STAT3 pathway in oral epithelial precursor lesions and squamous cell carcinoma2020

    • Author(s)
      Tashiro K Oikawa M Miki Y Takahashi T Kumamoto H
    • Journal Title

      Odontology

      Volume: 108 Issue: 1 Pages: 91-101

    • DOI

      10.1007/s10266-019-00428-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical assessment of Eph/ephrin expression in oral squamous cell carcinoma and precursor lesions2020

    • Author(s)
      Saito H Oikawa M Kouketsu A Takahashi T Kumamoto H
    • Journal Title

      Odontology

      Volume: 108 Issue: 2 Pages: 166-173

    • DOI

      10.1007/s10266-019-00466-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of oestrogen deficiency and excessive stress on condylar head of mandible2020

    • Author(s)
      Nogami S Yamauchi K Odashima K Ito K Iikubo M Kumasaka A Martinez-de la Cruz G Gaggl A Kumamoto H Takahashi T
    • Journal Title

      Oral Dis

      Volume: 26 Issue: 8 Pages: 1718-1726

    • DOI

      10.1111/odi.13452

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 歯科における遺伝子検査のためのゲノム病理の確立2019

    • Author(s)
      三上俊成 井上孝 岡田康男 小川郁子 北川雅恵 熊本裕行 坂元啓 仙波伊知郎 髙田隆 武田泰典
    • Journal Title

      日歯医学会誌

      Volume: 38 Pages: 52-56

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 上顎類腱型エナメル上皮腫に対して遊離腸骨ブロック移植後にカスタムメイド・チタンメッシュトレーと自家腸骨海綿骨細片で上顎骨二次再建を施行した1例2019

    • Author(s)
      大竹義雄 野上晋之介 佐藤工 山内健介 熊本裕行 髙橋哲
    • Journal Title

      日口外誌

      Volume: 65 Pages: 16-21

    • NAID

      130007617371

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical assessment of chromatin licensing and DNA replication factor 1, geminin, and gamma-H2A.X in oral epithelial precursor lesions and squamous cell carcinoma2019

    • Author(s)
      Siril YJ Kouketsu A Oikawa M Takahashi T Kumamoto H
    • Journal Title

      J Oral Pathol Med

      Volume: 48 Issue: 10 Pages: 888-896

    • DOI

      10.1111/jop.12925

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma2019

    • Author(s)
      Kouketsu A Sato I Oikawa M Shimizu Y Saito H Tashiro K Yamashita Y Takahashi T Kumamoto H
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 48 Issue: 10 Pages: 1279-1288

    • DOI

      10.1016/j.ijom.2019.04.004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of immunoregulatory molecules PD-L1 and PD-1 in oral cancer and precancerous lesions: A cohort study of Japanese patients2018

    • Author(s)
      Kouketsu A Sato I Oikawa M Shimizu Y Saito H Takahashi T Kumamoto H
    • Journal Title

      J Craniomaxillofac Surg

      Volume: 46 Issue: 1 Pages: 33-40

    • DOI

      10.1016/j.jcms.2017.04.013

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯原性腫瘍の分子病理学-エナメル上皮腫を中心に-2018

    • Author(s)
      熊本裕行
    • Journal Title

      日口科誌

      Volume: 67 Pages: 252-259

    • NAID

      130007593836

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical assessment of hypoxia-inducible factor-1α (HIF-1α) and carbonic anhydrase IX (CA IX) in ameloblastomas2018

    • Author(s)
      Arima Y Oikawa M Shimizu Y Echigo S Takahashi T Kumamoto H
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: 30 Issue: 3 Pages: 294-300

    • DOI

      10.1016/j.ajoms.2017.10.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral clear cell variant of calcifying epithelial odontogenic tumor devoid of calcification2018

    • Author(s)
      Kurihara A Mori S Oikawa M Kumamoto H Takahashi T
    • Journal Title

      Journal of Oral Science

      Volume: 60 Issue: 3 Pages: 469-472

    • DOI

      10.2334/josnusd.17-0116

    • NAID

      130007487194

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性歯原性腫瘍2018

    • Author(s)
      武田泰典 入江太郎 熊本裕行
    • Journal Title

      病理と臨床

      Volume: 36 Pages: 318-322

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔癌における骨髄由来抑制系細胞および形質細胞様樹状細胞に関する臨床病理学的研究2021

    • Author(s)
      纐纈衆 髙橋哲 熊本裕行
    • Organizer
      第39回日本口腔腫瘍学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 口腔癌と前癌病変の病理とその臨床適用2020

    • Author(s)
      熊本裕行
    • Organizer
      宮城県歯科医師会・東北大学病院合同講習会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 舌扁平上皮癌における原発巣の深度に関する病理学的臨床検討2020

    • Author(s)
      黒田佳奈子 北村淳 野上晋之介 山内健介 宮下仁 永井宏和 熊本裕行 髙橋哲
    • Organizer
      第65回日本口腔外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Oral cancer in Haiti and promotion of my research on oncology in Japan2020

    • Author(s)
      Siril YJ Takahashi T Kuroda K Kumamoto H
    • Organizer
      第38日本口腔腫瘍学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Facial asymmetry and unilateral condylar hyperplasia treated with ipsolateral condylectomy and orthodontic treatment2020

    • Author(s)
      Kishikawa A Fukunaga T Nogami S Seiryu M Shigemi S Kumamoto H Takahashi T Mizoguchi I
    • Organizer
      The 9th International Orthodontic Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral cancer in Haiti and promotion of my research on oncology in Japan2020

    • Author(s)
      Siril YJ Takahashi T Kuroda K Kumamoto H
    • Organizer
      第38回日本口腔腫瘍学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 顎口腔疾患の病理2019

    • Author(s)
      熊本裕行
    • Organizer
      第33回宮城県臨床細胞学会学術集会
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Invited
  • [Presentation] 口腔癌と前癌病変2019

    • Author(s)
      熊本裕行
    • Organizer
      宮城県歯科医師会・東北大学病院合同講習会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 歯原性腫瘍の分子病理学2018

    • Author(s)
      熊本裕行
    • Organizer
      第52回日本口腔科学会関東地方部会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 顎口腔疾患の病理2018

    • Author(s)
      熊本裕行
    • Organizer
      平成29年度宮城県臨床検査技師会学術研修会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 上顎に生じたエナメル上皮癌の1例2018

    • Author(s)
      君塚哲 熊本裕行 伊藤正健
    • Organizer
      第63回日本口腔外科学会総会
    • Related Report
      2018 Research-status Report
  • [Book] 新口腔病理学 第3版2021

    • Author(s)
      熊本裕行(下野正基 高田隆 田沼順一 豊澤悟 編)
    • Total Pages
      364
    • Publisher
      医歯薬出版
    • ISBN
      9784263458594
    • Related Report
      2020 Annual Research Report
  • [Book] 口腔がん・口腔粘膜病変:診査と連携のてびき 2020年版2020

    • Author(s)
      髙橋哲 熊本裕行 宮下仁
    • Total Pages
      12
    • Publisher
      宮城県歯科医師会/東北大学大学院歯学研究科
    • Related Report
      2020 Annual Research Report
  • [Book] 癌診療指針のための病理診断プラクティス「唾液腺/口腔・歯原性腫瘍」2019

    • Author(s)
      熊本裕行(青笹克之 長尾俊孝 高田隆 編)
    • Total Pages
      380
    • Publisher
      中山書店
    • ISBN
      9784521742724
    • Related Report
      2019 Research-status Report
  • [Book] 新口腔病理学 第2版2018

    • Author(s)
      熊本裕行(下野正基 高田隆 田沼順一 豊澤悟 編)
    • Total Pages
      359
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report
  • [Book] 口腔病理アトラス 第3版2018

    • Author(s)
      熊本裕行(高田隆 豊澤悟 編)
    • Total Pages
      380
    • Publisher
      文光堂
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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