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GDF6 in Aging of Periodontal Tissue

Research Project

Project/Area Number 18K09639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionKagoshima University

Principal Investigator

Sena Kotaro  鹿児島大学, 医歯学域歯学系, 助教 (60701117)

Co-Investigator(Kenkyū-buntansha) 迫田 賢二  鹿児島大学, 医歯学域歯学系, 助教 (70419654)
古江 きらら  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (10813157)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords歯周疾患 / 老化 / 歯根膜細胞 / GDF6 / 歯根膜由来細胞 / 歯根膜幹由来細胞 / 歯周組織 / 幹細胞
Outline of Final Research Achievements

Aging is a phenomenon that affects all tissues in the body and causes deterioration in maintaining tissue homeostasis and wound healing ability. At present, most studies related to periodontal tissue regeneration have rarely verified the effect of aging in regenerated tissues and individuals. In this study, we analyzed whether the expression of growth differentiation factor 6 (GDF6), which is one of the growth factors expressed in periodontal tissue, is affected by the aging of human periodontal ligament cells and the expression of proteins related to aging. From this study, it is considered that GDF6 is involved in the aging of periodontal tissue.

Academic Significance and Societal Importance of the Research Achievements

本研究結果より、老化に伴い、歯周組織におけるGDF6の発現が減弱し、老化に関連するタンパク質の発現の亢進を認めた。このことは、加齢とともに増加する歯周病の発症および高齢者で重症化し易い歯周治療に関する研究分野において、重要な知見となり得る。我々の研究結果により、GDF6が歯周病の発症および予防に関わる因子となる可能性が示唆された。このことは、GDF6に着目した新しい歯周治療のアプローチを提供できると考えられ、社会的にも有意義である。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2021 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and prostaglandin E2 in human gingival fibroblasts2021

    • Author(s)
      Sena Kotaro、Furue Kirara、Setoguchi Fumiaki、Noguchi Kazuyuki
    • Journal Title

      Archives of Oral Biology

      Volume: 129 Pages: 105201-105201

    • DOI

      10.1016/j.archoralbio.2021.105201

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontal tissue regeneration after low‐intensity pulsed ultrasound stimulation with or without intra‐marrow perforation in two‐wall intra‐bony defects?A pilot study in dogs2019

    • Author(s)
      Shirakata Yoshinori、Imafuji Takatomo、Sena Kotaro、Shinohara Yukiya、Nakamura Toshiaki、Noguchi Kazuyuki
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 47 Issue: 1 Pages: 54-63

    • DOI

      10.1111/jcpe.13197

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Porphyromonas gingivalis 由来 lipopolysaccharide の骨細胞への影響2019

    • Author(s)
      瀬名浩太郎 , 古江きらら , 野口和行
    • Organizer
      第 1 回南九州歯学会総会 ・ 学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Periodontal regenerative effect of low-intensity pulsed ultrasound with/without intramarrow perforation in intrabony defects in dogs2019

    • Author(s)
      Y Shirakata, T Imafuji, K Sena, Y Shinohara, T Nakamura, K Noguchi
    • Organizer
      IAP 2019 The 17th Biennial Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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