| Project/Area Number |
18K09688
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Makihara Eri 九州歯科大学, 歯学部, 講師 (30433402)
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| Co-Investigator(Kenkyū-buntansha) |
宮嶋 隆一郎 九州歯科大学, 歯学部, 助教 (30773379)
渡辺 崇文 九州歯科大学, 歯学部, 助教 (10845390)
鱒見 進一 九州歯科大学, 歯学部, 教授 (70181659)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 閉塞性睡眠時無呼吸症 / 口腔内装置 / 治療顎位 / 装着感 / 睡眠状態 / 閉塞型睡眠時無呼吸紹介症 / 閉塞型睡眠時無呼吸 / 閉塞型睡眠時無呼吸症 |
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| Outline of Final Research Achievements |
Eight Patients with OSA responses regarding sensation and sleeping conditions when each two types of appliance was fitted were compared. Almost patients preferred soft-type OA, which is more comfortable to wear to and less pain and discomfort to hard-type OA.
Thirty-two patients with OSA were randomly allocated to receive a 50% mandibular advancement or a 75% mandibular advancement with an OA. There was no significant difference in treatment effectiveness between groups. For patients with mild to moderate OSA, 50% mandibular advancement is recommended as the initial therapeutic mandibular position. It was suggested that gender differences also affect treatment effectiveness.
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| Academic Significance and Societal Importance of the Research Achievements |
閉塞性睡眠時無呼吸（Obstructive sleep apnea：OSA)に対し歯科では口腔内装置（Oral appliance:OA)治療を行うが，OAの副作用により使用困難な患者が存在する．
そこで，患者にとって受け入れられやすいOAの改良を行うために材質による装着感を比較したところ，硬質素材より軟性素材のOAの方が受け入れられやすいことがわかった．また，下顎50％前方位と75%前方位におけるOAの治療効果を比較したところ，治療効果に有意差が認められなかったことから，初期的なOAの治療顎位は，より顎関節部への負担が少ない下顎50％位で十分であることが示唆された．
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