| Project/Area Number |
18K09779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
ozawa shigeyuki 神奈川歯科大学, 大学院歯学研究科, 講師 (40434394)
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| Co-Investigator(Kenkyū-buntansha) |
畑 隆一郎 神奈川歯科大学, 大学院歯学研究科, 特任教授 (10014276)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部扁平上皮癌 / 糖代謝 / CXCL14 / GPRC5B / 頭頚部癌 / 頭頚部扁平上皮癌 / GPRC5b / 頭頸部癌 / ケモカイン |
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| Outline of Final Research Achievements |
GPRC5B is a diabetes-causing gene, which can be a receptor for CXCL14. In this study, we analysed the function of GPRC5B in cancer cells. We revealed that the expression level of GPRC5B in head-and-neck squamous carcinoma cells was involved in the prognosis of tumour-bearing patients, and that tumour-bearing patients with high expression of GPRC5B had a shorter 5-year survival rate compared to those with low expression of GPRC5B. We also revealed that head-and-neck squamous cell carcinoma cells with higher expression of GPRC5B showed reduced glucose-dependence and avoided apoptosis during glucose-starvation. We also showed, as a mechanism, that head and neck squamous cell carcinoma cells, with high GPRC5B expression may change their nutrient source from glucose to lipids during glucose starvation.
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| Academic Significance and Societal Importance of the Research Achievements |
CXCL14と同様にGPRC5Bの糖代謝における機能解析は、糖尿病について行われたものであり、癌については着目されていなかった。現在、GPRC5Bを標的とした糖尿病治療薬の開発が進んでいる。この糖尿病治療薬を、癌治療に応用することや、ケトン食療法の有効性の評価など、本研究は今後の癌研究の基盤となることが予想される。本研究成果は、はじめて、癌におけるGPRC5Bの機能解析を行ったものであり、新たな治療戦略を立案するためにも意義があるものと考えられる。
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