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Mechanisms of dysgeusia induced by taste receptor dysfunction

Research Project

Project/Area Number 18K09884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionNagasaki University

Principal Investigator

FUJIYAMA Rie  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10274664)

Co-Investigator(Kenkyū-buntansha) 久芳 さやか  長崎大学, 病院(医学系), 助教 (90437880)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords味覚障害 / 味覚異常 / 化学療法 / 抗がん剤 / 副作用 / 味覚
Outline of Final Research Achievements

The prevalence of chemotherapy-induced taste disorders, including dysgeusia, which is regarded as a reduction in taste sensitivity, is approximately 60%. However, most reports are based on subjective patient symptoms. In this study, two methods of analysis were used: a basic behavioral study in rats to analyze changes in preference for the basic tastes before and after chemotherapy, and a clinical study comparing the taste sensitivity of breast cancer patients before and after chemotherapy using two objective taste tests. The results showed that the effect of chemotherapy on taste varied according to tongue site, and that changes in taste sensitivity differed for the basic tastes. Chemotherapy could not only decrease but also increase taste sensitivity. Moreover, these changes occurred immediately after the start of chemotherapy and recovered early after the end of chemotherapy, and the effects on the basic tastes differed depending on the type of anticancer drug used.

Academic Significance and Societal Importance of the Research Achievements

化学療法だけでなくさまざまな原因による味覚障害のメカニズムについては未だ明らかになっていない。本研究における化学療法による味覚変化の解明は、今後の様々な副作用を含めた味覚研究を行う上で、学術的な基盤になると考える。化学療法による味覚変化は、味覚障害のモデルとして利用できる可能性があり、今後研究対象を広げることなどにより、化学療法のみならずすべての味覚障害解明に繋がる可能性が考えられる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2022 2021 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Chemotherapy-induced Dysgeusia2022

    • Author(s)
      FUJIYAMA RIE、SUMI TADATERU
    • Journal Title

      Japanese Journal of Oral Diagnosis / Oral Medicine

      Volume: 35 Issue: 3 Pages: 173-182

    • DOI

      10.15214/jsodom.35.173

    • ISSN
      0914-9694, 2188-2843
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Awareness of dysgeusia and gustatory tests in patients undergoing chemotherapy for breast cancer2018

    • Author(s)
      Kuba Sayaka、Fujiyama Rie、Yamanouchi Kosho、Morita Michi、Sakimura Chika、Hatachi Toshiko、Matsumoto Megumi、Yano Hiroshi、Takatsuki Mitsuhisa、Hayashida Naomi、Nagayasu Takeshi、Eguchi Susumu
    • Journal Title

      Supportive Care in Cancer

      Volume: 26 Issue: 11 Pages: 3883-3889

    • DOI

      10.1007/s00520-018-4256-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Side effects of anticancer drug on bitter and umami taste sensitivities2022

    • Author(s)
      藤山理恵
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Paclitaxel alters sour-taste sensitivity in rats2019

    • Author(s)
      Fujiyama, Rie
    • Organizer
      第61回 歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report
  • [Book] CLINICAL NEUROSCIENCE Vol.39 No2 分担執筆(C. 障害 がん:p210-213)2021

    • Author(s)
      藤山理恵
    • Total Pages
      252
    • Publisher
      中外医学社
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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