The new countermeasure for xerostomia to use mouth moisturizers containing "umami" ingredients
| Project/Area Number |
18K09903
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 57080:Social dentistry-related
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
阿部 貴惠 北海道大学, 大学病院, 助教 (00455677)
近藤 美弥子 北海道大学, 歯学研究院, 助教 (10631864)
山崎 裕 北海道大学, 歯学研究院, 教授 (90250464)
|
|---|
| Project Period (FY) |
2018-04-01 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 口腔乾燥 / 口腔保湿剤 / うま味 / 味覚 |
|---|
| Outline of Final Research Achievements |
We focused on the facts that "umami" ingredients continuously secreted saliva. We planed to establish the optimum concentration of "umami" ingredients for saliva secretion in older adults, develop mouth moisturizers containing "umami" ingredients, and verify the effects of the moisturizer on the improvement of xerostomia in older adults. However, the epidemic of COVID-19 infection prevented these studies. Therefore, we decided to set the optimum concentration of "umami" ingredients for normal young adults. We confirmed whether stimulation by the "umami" ingredients showed a similar tendency for salivation, as in the results of previous studies. No similar results could be disappointingly obtained. Thus we conclude that the optimum concentration of "umami" ingredients was not elucidated.
|
| Academic Significance and Societal Importance of the Research Achievements |
わが国は超高齢社会の進展により口腔乾燥患者が急増している。口腔乾燥に対しては対症療法として口腔保湿剤が使用されることが多く、有効とされている。口腔保湿剤には唾液分泌促進効果を狙ったフレーバーが付与されているものが散見され、そのうち酸味が多く、これは刺激が強すぎて苦痛となるばかりでなく、その効果も限定的であるといわれている。近年、酸味よりも「うま味」の方が持続的に唾液を分泌することが報告されており、口腔保湿剤に「うま味」が配合されていれば、口腔乾燥症に対するより有効な対処法になると発想した。本研究ではその有効性を示すことは困難であったが、今後の口腔乾燥症対策の一助となると考える。
|
Report
(5 results)
Research Products
(21 results)
-
[Journal Article] Oral frailty and carriage of oral Candida in community‐dwelling older adults (Check‐up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa)2022
Author(s)
Baba Haruhisa, Watanabe Yutaka, Miura Kazuhito, Ozaki Kimiya, Matsushita Takae, Kondoh Miyako, Okada Kazutaka, Hasebe Akira, Ayabe Tokiyoshi, Nakamura Kiminori, Nakaoka Shinji, Ogasawara Katsuhiko, Suzuki Teppei, Saito Hiroshi, Kimura Takashi, Tamakoshi Akiko, Yamazaki Yutaka
-
Journal Title
Gerodontology
Volume: 39
Issue: 1
Pages: 49-58
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Association between Weight Loss and Food Form in Older Individuals Residing in Long-Term Care Facilities: 1-Year Multicenter Longitudinal Study2021
Author(s)
Endo Akemi, Watanabe Yutaka, Matsushita Takae, Okada Kazutaka, Ohara Yuki, Iwasaki Masanori, Ito Kayoko, Nakajima Junko, Iwasa Yasuyuki, Itoda Masataka, Sasaki Rikimaru, Nishi Yasuhiro, Furuya Junichi, Watanabe Yoshihiko, Umemoto George, Kishima Masako, Hirano Hirohiko, Sato Yuji, Yoshida Mitsuyoshi, Yamazaki Yutaka
-
Journal Title
International Journal of Environmental Research and Public Health
Volume: 18
Issue: 20
Pages: 10776-10776
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
