Examination of the plasma miRNA profiles in adult T-cell leukemia (ATL)
| Project/Area Number |
18K10050
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
NIINO Daisuke 長崎大学, 医歯薬学総合研究科(医学系), 客員教授 (20426563)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岩永 正子 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00372772)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 成人T細胞白血病 / バイオマーカー / マイクロRNA / 成人Ｔ細胞白血病リンパ腫 / マイクロＲＮＡ / ATL / miRNA / HTLV-1 |
|---|
| Outline of Final Research Achievements |
To explore a potential novel biomarker, we examined the plasma miRNA profiles in adult T-cell leukemia (ATL) characterized by diverse clinical features. Plasma samples from 6 ATL patients (acute: 3 patients; chronic: 3 patients), 3 HTLV-1 carriers and 3 HTLV-1 uninfected volunteers were used to evaluate about 2600 kinds of miRNAs. miR-92，miR-19 may be a biomarker to decide development of acute ATL, or transformation of chronic ATL. Let-7 family may be a biomarker to decide development and transformation of chronic subtype ATL. miR-130 may be a biomarker to decide development of chronic ATL.
|
| Academic Significance and Societal Importance of the Research Achievements |
現在、血清レベルで簡便にHTLV-1キャリアからATL発症を予測できる分子マーカー発現異常は報告されていない。本研究では、血清中miRNAレベルがATL発症スクリーニングのためのバイオマーカーとなりうるかどうかを明らかにするために血清中miRNAレベルを測定した。 少数例ではあるがmiR-92、miR-19は急性型 ATL発症および慢性型ATLの急性転化の、 Let-7 familyは慢性型ATL発症および急性転化の、miR-130は慢性型ATL発症のバイオマーカーなる可能性があることがわかった。今後多数例の検討を行うことで、ATL 発症予測スクリーニング検査への応用が可能となるだろう。
|
Report
(4 results)
Research Products
(16 results)
-
-
-
[Journal Article] Impact of local high doses of radiation by neutron activated Mn dioxide powder in rat lungs: Protracted pathologic damage initiated by internal exposure.2020
Author(s)
Shichijo K, Takatsuji T, Abishev Z, Uzbekov D, Chaizhunusova N, Shabdarbaeva D, Niino D, Kurisu M, Takahashi Y, Stepanenko V, Azhimkhanov A, Hoshi M.
-
Journal Title
Biomedicines
Volume: 8
Issue: 6
Pages: 171-171
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality2019
Author(s)
Toriyama E, Imaizumi Y, Tsuruda K, Itonaga H, Sato S, Ando K, Sawayama Y, Hasegawa H, Hata T, Niino D, Yanagihara K, Miyazaki Y
-
Journal Title
Internal Medicine
Volume: 58
Issue: 15
Pages: 2213-2217
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2019-08-01
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] Gingival squamous cell carcinoma diagnosed on the occasion of osteonecrosis of the jaw in a patient with chronic GVHD2019
Author(s)
Tsukada S, Itonaga H, Taguchi J, Miyoshi T, Hayashida S, Sato S, Ando K, Sawayama Y, Imaizumi Y, Hata T, Umeda M, Niino D, Miyazaki Y
-
Journal Title
Rinsho Ketsueki
Volume: 60
Issue: 1
Pages: 22-27
DOI
NAID
ISSN
0485-1439, 1882-0824
Related Report
Peer Reviewed
-
-
-
-
-
