Analysis of the mechanism of the intensification of stagnation mastitis severity with the food ingredient
| Project/Area Number |
18K10466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58070:Lifelong developmental nursing-related
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| Research Institution | University of Miyazaki |
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Principal Investigator |
Eto Nozomu 宮崎大学, 農学部, 准教授 (90232959)
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| Co-Investigator(Kenkyū-buntansha) |
窄野 昌信 宮崎大学, 農学部, 教授 (70253515)
篠原 久枝 宮崎大学, 教育学部, 教授 (40178885)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | mastitis / 乳腺炎 |
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| Outline of Final Research Achievements |
Mastitis is one of the inhibitory factors in beneficial breastfeeding. We have found that specific dietary ingredients alone are inadequate as the cause of mastitis. However, we have found that "congestive mastitis" caused by milk congestion is aggravated by ingested sucrose daily. Since eating sucrose also causes inflammation in the liver, the relationship between liver inflammation and mastitis was investigated. As a result, although mastitis is independent of liver inflammation, it was suggested that LDL derived from the liver might affect the mammary gland tissue due to eating a high-fat, high-sucrose diet.
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| Academic Significance and Societal Importance of the Research Achievements |
母乳哺育は母児に対して好ましい影響を与えることから、ユニセフ、WHOなどの機関は母乳哺育を推奨している。しかし、乳腺炎の発症により授乳が困難になるケースがある。乳腺炎は強い炎症を伴う乳房疾患の総称で、授乳中の母親のうち9~33%が発症する。乳汁の貯留が引き金となる「急性うっ滞性乳腺炎」に食事成分の関与が疑われていたが科学的な根拠はなかった。しかし、研究代表者らはうっ滞性乳腺炎が食事成分によって重篤化すること等を見出し、初めて科学的な根拠を与えた。
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Report
(5 results)
Research Products
(31 results)
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[Journal Article] 完熟きんかん摂食に伴う血清βクリプトキサンチン濃度の検討 ―ランダム化非盲検非摂食同時対照群間比較試験―2019
Author(s)
有村保次, 武安智樹, 米澤ゆう子, 永濵清子, 神力はるな, 近藤知巳, 上野浩晶, 松元信弘, 江藤望, 榊原陽一, 水光正仁, 片岡寛章
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Journal Title
薬理と治療
Volume: 47
Pages: 65-75
Related Report
Peer Reviewed
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[Journal Article] Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene2019
Author(s)
Rina Terao, Akira Murata, Kazuhiro Sugamoto, Tomoko Watanabe, Kiyoko Nagahama, Keiko Nakahara, Tomomi Kondo, Noboru Murakami, Keiichi Fukui, Hidemi Hattori, Nozomu Eto
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Journal Title
Food & Function
Volume: 10
Issue: 1
Pages: 38-48
DOI
Related Report
Peer Reviewed
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[Journal Article] Naturally occurring 3RS, 7R, 11R-phytanic acid suppresses in vitro T-cell production of interferon-gamma2018
Author(s)
Tomonori Nakanishi, Ibuki Motoba, Mayuko Anraku, Ryoji Suzuki, Yuto Yamaguchi, Laurie Erickson, Nozomu Eto, Kazuhiro Sugamoto, Yohichi Matsushita and Satoshi Kawahara
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Journal Title
Lipids in Health and Disease
Volume: 17
Issue: 1
Pages: 147-147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 金柑とその活性成分によるNK細胞賦活効果2018
Author(s)
寺尾莉奈, 村田彬, 菅本和寛, 渡辺朋子, 永濵清子, 中原桂子, 近藤知巳, 村上昇, 福井敬一, 服部秀美, 江藤望
Organizer
平成30年度日本栄養・食糧学会 九州・沖縄支部大会
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