Elucidation of postural abnormalities and postural instability in Parkinson's disease: A Study from the effectiveness of deep brain stimulation.
| Project/Area Number |
18K10760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Juntendo University |
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Principal Investigator |
Izawa Nana 順天堂大学, 保健医療学部, 非常勤講師 (60384038)
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| Co-Investigator(Kenkyū-buntansha) |
岩室 宏一 順天堂大学, 医学部, 准教授 (80384775)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | パーキンソン病 / 姿勢異常 / 足底圧 / 立位 / 歩行 / 体軸症状 / 足底圧分析 / 脳深部刺激療法 |
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| Outline of Final Research Achievements |
To investigate the trunk dysfunction in Parkinson's disease (PD), we measured plantar pressure of PD patients during standing and walking on a treadmill. We also examined an effect of subthalamic nucleus deep brain stimulation (STN-DBS) on their trunk function.
The subjects were divided into two groups, with (PD+) and without (PD-) camptocormia. In the standing evaluation, the PD+ group was significantly more backward loaded. In the gait evaluation, the lack of sufficient heel loading at the loading response phase was more notable in the PD+ group. At the initial contact, they contacted their whole sole of foot on the ground. Regarding the effect of the STN-DBS, it temporarily deteriorated the trunk sway during standing just after the surgery, but gradually recovered. In the gait analysis after the STN-DBS, the subjects showed an increase in heel loading at the initial ground contact.
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| Academic Significance and Societal Importance of the Research Achievements |
姿勢異常を伴うパーキンソン病（PD）患者では、立位時に後方荷重になっていることを明らかにした。これが、後方への易転倒性の原因の一つであることが考えられる。意識的に前方荷重にすることで転倒のリスクを軽減できれば、PD患者に周知することで転倒、骨折やそれに伴うADLの低下を防げる可能性があり、社会的意義は大きい。
また、PDによる歩行障害については、初期接地時の踵荷重が減少し、全足底接地になっていることがわかった。また、視床下核脳深部刺激療法（STN-DBS）後に正常歩行に近づくことが示された。PDにおける歩行障害がSTN-DBSによって改善する可能性があり、学術的意義があると思われる。
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Report
(6 results)
Research Products
(8 results)
